Abstract: A system and method for securing a pump are disclosed. The system includes a pump that contains a medicament delivery system, a processor operably coupled to the pump, a user interface in operable communication with the processor, a plurality of sensors in operable communication with the processor, and a housing. The housing includes a frame, a door, and a locking mechanism that can be selectively unlocked to allow the door to partially detach from the frame. The security system includes a swivel door assembly, which includes physical redundancies to selectively prevent access to the internal space of the swivel door assembly and a plurality of alarms. For example, in response to receiving an input from the plurality of sensors, the processor initiates at least one of the plurality of alarms to provide an indication to a user that an event has occurred.

Abstract: A plastic, hot-fillable container is provided. The container comprises a blow molded body including a neck and a base having a center portion and a plurality of spaced apart radial segments. At least a portion of each segment is tapered from an outer side to an inner side thereof. Container systems and methods of manufacturing containers are disclosed.

Abstract: A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)

Abstract: A method for manufacturing a container includes injecting a first material into a first mold to form a top portion of a preform. The first material and a second material are injected into the first mold to form a bottom portion of the preform. The preform is disposed in a second mold. The preform is blow molded into a finished container.

Abstract: Example implementations may relate to methods and systems for detecting an event in a physical region within a physical space. Accordingly, a computing system may receive from a subscriber device an indication of a virtual region within a virtual representation of the physical space such that the virtual region corresponds to the physical region. The system may also receive from the subscriber a trigger condition associated with the virtual region, where the trigger condition corresponds to a particular physical change in the physical region. The system may also receive sensor data from sensors in the physical space and a portion of the sensor data may be associated with the physical region. Based on the sensor data, the system may detect an event in the physical region that satisfies the trigger condition and may responsively provide to the subscriber a notification that indicates that the trigger condition has been satisfied.

Abstract: A container includes a body having opposite top and bottom walls. Opposite front and back walls each extend from the top wall to the bottom wall. Opposite first and second side walls each extend from the top wall to the bottom wall and from the front wall to the back wall. A spout extends from the top wall. A flange extends from the top wall. A handle extends from the spout to the flange.

Abstract: A food packaging container is provided. The container comprises a molded body defining a longitudinal axis, and including a plurality of sides and a plurality of axial corners. Each corner has a recess including a first portion and a second portion. Each of the first portions includes an axial grip surface where the grip surfaces are aligned with the body in an orientation for gripping. In some embodiments, packaging products, containers, handles, tooling, applicators and methods are disclosed.

Abstract: A method for manufacturing a container includes injecting a first material into a first mold to form a top portion of a preform. The first material and a second material are injected into the first mold to form a bottom portion of the preform. The preform is disposed in a second mold. The preform is blow molded into a finished container.

Abstract: A method for manufacturing a container includes injecting a first material into a first mold to form a top portion of a preform. The first material and a second material are injected into the first mold to form a bottom portion of the preform. The preform is disposed in a second mold. The preform is blow molded into a finished container.

Abstract: The present disclosure provides a process for preparing an aryl ketone of Formula I, comprising reacting a substituted benzene of Formula II with a carboxylic acid of formula IIIa and/or a carboxylic anhydride of formula IIIb in presence of an alkyl sulfonic acid acting as catalyst cum solvent/contacting medium. I, II, IIIa, IIIb, wherein, R1, R2, R3 and R4 are as defined in the description.

Abstract: Described herein are fermention organisms, such as yeasts, comprising a genetic modification that increases or decreases expression of a transporter or regulator thereof, such as yeasts that express the FOT2 and FOTX transporters of SEQ ID NOs: 163 and 164. Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the fermenting organisms.

Abstract: Various examples described herein are directed to systems and methods that learn to evaluate data items. A computing device receives data items and evaluates the data items. The evaluation performed by the computing device includes comparing a first data item with a second data item and determining a difference between the first data item and the second data item based on the comparison. The computing device also prepares a recommendation based on the difference between the first data item and the second data item and forwards the recommendation to a subject matter expert. The computing device receives an updated recommendation from the subject matter expert that is based on the recommendation. Using the updated recommendation, the computing device refines the comparing and determining operations where the computing device further learns to evaluate the data items by receiving the updated recommendation and refining the comparing and determining operations.

Abstract: A food packaging container is provided. The container comprises a molded body defining a longitudinal axis, and including a plurality of sides and a plurality of axial corners. Each corner has a recess including a first portion and a second portion. Each of the first portions includes an axial grip surface where the grip surfaces are aligned with the body in an orientation for gripping. In some embodiments, packaging products, containers, handles, tooling, applicators and methods are disclosed.

Abstract: Described herein are fermention organisms, such as yeasts, comprising a genetic modification that increases or decreases expression of a transporter or regulator thereof, such as yeasts that express an Amino Acid/Auxin Permease (AAAP). Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the fermenting organisms.

Abstract: A chemotherapy agent comprising a chemotherapy group and a ligand secured to the chemotherapy group is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing chemotherapy agents from a patient is disclosed, the method comprising providing a chemotherapy agent containing a reactive group; providing a capture substrate in contact with a patient's bloodstream; administering the chemotherapy agent to the patient; and sequestering the chemotherapy agent on the capture substrate. A system for removing chemotherapy agents is also disclosed.

Abstract: The present disclosure provides a process for preparing an aryl ketone of Formula I, comprising reacting a substituted benzene of Formula II with a carboxylic acid of formula IIIa and/or a carboxylic anhydride of formula IIIb in presence of an alkyl sulfonic acid acting as catalyst cum solvent/contacting medium. I, II, IIIa, IIIb, wherein, R1, R2, R3 and R4 are as defined in the description.

Abstract: Disclosed herein is an efficient, environment friendly and commercially viable process for preparation of chloromethylated compound of formula I in substantially pure form and high yield, from the compound of formula II. The process includes contacting the compound of formula II with a chloromethylating agent generated in-situ by reaction of a formaldehyde precursor and hydrogen chloride, in a suitable solvent/contacting medium and in the presence of a catalytic amount of a short chain/low molecular weight carboxylic acid of formula III. I II III wherein, R1, R2, R3 and R4 are as defined in the description.

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.