Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

Abstract: Example implementations may relate to methods and systems for detecting an event in a physical region within a physical space. Accordingly, a computing system may receive from a subscriber device an indication of a virtual region within a virtual representation of the physical space such that the virtual region corresponds to the physical region. The system may also receive from the subscriber a trigger condition associated with the virtual region, where the trigger condition corresponds to a particular physical change in the physical region. The system may also receive sensor data from sensors in the physical space and a portion of the sensor data may be associated with the physical region. Based on the sensor data, the system may detect an event in the physical region that satisfies the trigger condition and may responsively provide to the subscriber a notification that indicates that the trigger condition has been satisfied.

Abstract: A plastic, hot-fillable container is provided. The container comprises a blow molded body including a neck and a base having a center portion and a plurality of spaced apart radial segments. At least a portion of each segment is tapered from an outer side to an inner side thereof. Container systems and methods of manufacturing containers are disclosed.

Abstract: A method for manufacturing a container includes injecting a first material into a first mold to form a top portion of a preform. The first material and a second material are injected into the first mold to form a bottom portion of the preform. The preform is disposed in a second mold. The preform is blow molded into a finished container.

Abstract: Personalization of Internet search is effected through the use of ResultRank and searcher selected profile attributes and searcher selected query context attributes. These attributes are also referred to as hats (worn by the searcher). Searcher privacy is maintained by allowing limited use of a searcher's profile by the search engine. Query language interpretation is improved by capture and use of searcher behavior and hat selection, in past search sessions, without storage of individual profile or context information. ResultRank is maintained and adjusted, on a per hat basis such that future, similarly hatted searchers benefit from these past sessions. An average of ResultRank, across searcher selected hats, is utilized for improved SERP ranking Recognition of QLP's is improved by use of the hats. Custom support of public and private language community circles is incorporated. The technique is applied to organic as well as sponsored results.

Abstract: An edge trimming apparatus includes a chuck table that causes a ring-shaped groove with an outer diameter smaller than the outer diameter of a wafer to communicate with a suction source to hold under suction a lower surface of the wafer by the ring-shaped groove, a cutting unit that rotates a cutting blade and annularly cuts a circumferential part of the wafer held by the chuck table, and a cleaning unit that cleans a region outside the ring-shaped groove in the upper surface of the table and the upper surface of the table including the ring-shaped groove. The cleaning unit is positioned to the region outside the ring-shaped groove in the upper surface of the table and the upper surface of the chuck table including the ring-shaped groove, and the chuck table is rotated to clean the ring-shaped groove and the upper surface.

Abstract: Disclosed is a seal for an engine firewall. The seal including a proximal part having a recess; a distal part having a notch; and a flexible intermediate part integrally extending between the proximal part and the distal part.

Abstract: A method of forming a cochlear implant electrode array includes positioning contact array assembly, which includes at least one carrier and a plurality of contacts on the at least one carrier, in a mold, removing at least a portion of the at least one carrier from the mold without removing that plurality of contacts from the mold, and introducing resilient material into the mold after the at least a portion of the at least one carrier has been removed to form a flexible body.

Abstract: A plastic, hot-fillable container is provided. The container comprises a blow molded body including a neck and a base having a center portion and a plurality of spaced apart radial segments. At least a portion of each segment is tapered from an outer side to an inner side thereof. Container systems and methods of manufacturing containers are disclosed.

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

Abstract: A system and method that provides a proximity sensor disposed within a door handle of a vehicle to enable one or more commands to be transmitted to the vehicle by a user's hand, wherein the door handle is in a harsh outdoor environment such that the door handle may be wet when the proximity sensor is used to detect the touch or presence of a user's hand, and wherein the proximity sensor is able to compensate for the presence of the water and enable reliable operation of the proximity sensor and thereby enable commands to be sent to the vehicle.

Abstract: The present application pertains to a braided dual-sided compression packing seal, methods for producing and using such a seal, and apparatuses suitable for producing such a seal. The braided dual-sided compression packing seal is made up of two or more different materials that are braided together in such a way that, in cross-section, the compression packing seal has an asymmetrical configuration relative to a first axis that is substantially perpendicular to the longitudinal axis and is substantially perpendicular to a side of the compression packing seal. Accordingly, when viewed in a cross-sectional plane, the compression packing seal may expose substantially only a first material along a first side of the seal, and substantially only a second material along a second side of the seal.

Abstract: A workpiece holding method for a workpiece having a bowl-shaped warp includes a mounting step of mounting the workpiece on a holding unit having a holding surface, a suction hole opening to the holding surface, and a suction passage for making selective communication between the suction hole and a vacuum source for producing a suction force, the workpiece being mounted on the holding surface of the holding unit, a liquid supplying step of supplying a liquid to the workpiece held on the holding surface so that the liquid flows into a gap defined between the holding surface and the workpiece to fill the gap, and a suction step of bringing the suction hole into communication with the vacuum source to suck the liquid and the workpiece and thereby hold the workpiece through the liquid on the holding surface under suction, after performing the liquid supplying step.

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

Abstract: Described herein are recombinant fermenting organisms having a heterologous polynucleotide encoding a protease. Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the recombinant fermenting organisms.

Abstract: The present invention relates to methods for degrading or converting a cellulosic material, comprising: treating the cellulosic material with an enzyme composition in the presence of a polypeptide having cellulolytic enhancing activity.

Abstract: A food packaging container is provided. The container comprises a molded body defining a longitudinal axis, and including a plurality of sides and a plurality of axial corners. Each corner has a recess including a first portion and a second portion. Each of the first portions includes an axial grip surface where the grip surfaces are aligned with the body in an orientation for gripping. In some embodiments, packaging products, containers, handles, tooling, applicators and methods are disclosed.

Abstract: The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.