Abstract: Embodiments herein relate to medical devices and methods for monitoring and/or treatment including the use of synthetic polymers exhibiting specific binding for compounds such as disease state markers or toxic substances. In an embodiment, a method of testing a patient for a disease state is included, the method can include withdrawing a fluid sample from the patient and contacting the fluid sample with an extracorporeal monitoring device. The extracorporeal monitoring device can include a microporous membrane. The microporous membrane can include a synthetic polymer, wherein the synthetic polymer exhibits binding specificity with a disease state marker. The method can further include evaluating the extracorporeal monitoring device for the presence of the disease state marker. Other embodiments are included herein.

Abstract: Disclosed herein is an efficient, environment friendly and commercially viable process for preparation of chloromethylated compound of formula I in substantially pure form and high yield, from the compound of formula II. The process includes contacting the compound of formula II with a chloromethylating agent generated in-situ by reaction of a formaldehyde precursor and hydrogen chloride, in a suitable solvent/contacting medium and in the presence of a catalytic amount of a short chain/low molecular weight carboxylic acid of formula III. I II III wherein, R1, R2, R3 and R4 are as defined in the description.

Abstract: Systems and methods for change management are provided. An electronic product and/or service provisioning system is tracked as a function of experiences. Changes are implemented at a process level, where two or more processes make up an experience.

Abstract: A method of forming a cochlear implant electrode array includes positioning a contact array assembly, which includes at least one carrier and a plurality of contacts on the at least one carrier, in a mold, removing at least a portion of the at least one carrier from the mold without removing the plurality of contacts from the mold, and introducing resilient material into the mold after the at least a portion of the at least one carrier has been removed to form a flexible body.

Abstract: A device may include a flexible material defining an exterior of a cavity, an interior electrode located within the cavity, a first peripheral electrode peripherally located with respect to the interior electrode on a first side of the interior electrode, a second peripheral electrode peripherally located with respect to the interior electrode on a second side of the interior electrode where the interior electrode is between the first peripheral electrode and the second peripheral electrode, a controller electrically connected to the interior electrode, the first peripheral electrode, and the second peripheral electrode, and programmed instructions written into memory of the controller where the programmed instructions cause the controller, when executed to measure a first capacitance between the first peripheral electrode and the interior electrode and measure a second capacitance between the second peripheral electrode and the interior electrode.

Abstract: Disclosed is a seal for an engine firewall. The seal including a proximal part having a recess; a distal part having a notch; and a flexible intermediate part integrally extending between the proximal part and the distal part.

Abstract: A method of forming a cochlear implant electrode array includes positioning contact array assembly, which includes at least one carrier and a plurality of contacts on the at least one carrier, in a mold, removing at least a portion of the at least one carrier from the mold without removing that plurality of contacts from the mold, and introducing resilient material into the mold after the at least a portion of the at least one carrier has been removed to form a flexible body.

Abstract: Described herein are recombinant fermenting organisms having a heterologous polynucleotide encoding an alpha-amylase and/or a heterologous polynucleotide encoding a trehalase. Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the recombinant fermenting organisms.

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

Abstract: A solid suspension for use in bone regeneration and/or the repair of bone defects, comprising a source of at least one group II metal cation and a source of zinc cations, wherein the source of zinc cations comprises zinc oxide and wherein where there is only one group II metal cation this is strontium. A bone graft comprising a solid suspension, a method of preparation of a solid suspension and a use of a solid suspension in bone regeneration and/or in the repair of bone defects.

Abstract: A plastic, hot-fillable container is provided. The container comprises a blow molded body including a neck and a base having a center portion and a plurality of spaced apart radial segments. At least a portion of each segment is tapered from an outer side to an inner side thereof. Container systems and methods of manufacturing containers are disclosed.

Abstract: A device may include a flexible material defining an exterior of a cavity, an interior electrode located within the cavity, a first peripheral electrode peripherally located with respect to the interior electrode on a first side of the interior electrode, a second peripheral electrode peripherally located with respect to the interior electrode on a second side of the interior electrode where the interior electrode is between the first peripheral electrode and the second peripheral electrode, a controller electrically connected to the interior electrode, the first peripheral electrode, and the second peripheral electrode, and programmed instructions written into memory of the controller where the programmed instructions cause the controller, when executed to measure a first capacitance between the first peripheral electrode and the interior electrode and measure a second capacitance between the second peripheral electrode and the interior electrode.

Abstract: A workpiece holding method for a workpiece having a bowl-shaped warp includes a mounting step of mounting the workpiece on a holding unit having a holding surface, a suction hole opening to the holding surface, and a suction passage for making selective communication between the suction hole and a vacuum source for producing a suction force, the workpiece being mounted on the holding surface of the holding unit, a liquid supplying step of supplying a liquid to the workpiece held on the holding surface so that the liquid flows into a gap defined between the holding surface and the workpiece to fill the gap, and a suction step of bringing the suction hole into communication with the vacuum source to suck the liquid and the workpiece and thereby hold the workpiece through the liquid on the holding surface under suction, after performing the liquid supplying step.

Abstract: A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)