Abstract: Apparatus and methods for rehabilitating a muscle are provided including one or more electrodes configured to be positioned in or adjacent to tissue, one or more sensors configured to sense muscle contraction and to generate a sensor signal based on the muscle contraction, and a pulse generator operatively coupled to the one or more electrodes, e.g., via a lead, and having a controller configured to receive the sensor signal and to adjust the stimulation frequency based on the sensor signal to cause the muscle to contract where muscle contraction is smooth and continuous.

Abstract: Embodiments of the present invention include a system and method for wirelessly identifying and validating an electronic device in order to initiate a communication process with another device or a service. In an embodiment, the system includes a portable biometric monitoring device that is identified by a client device or a server for the purpose of initiating a pairing process. In an embodiment, pairing implies pairing the portable device to an online user account with minimal user interaction. After pairing, the portable device and appropriate client devices and servers communicate with little or no user interaction, for example to upload sensor data collected by the portable device.

Abstract: A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire surface of kidney, and the image processing algorithm automatically segments and quantifies the diameter and/or density of the kidney microstructures, blood flows, etc., and quantitative values are displayed in real-time on a display of the KVAS.

Abstract: Applications in a broadcast environment distribute events in real-time to a large number of receivers within specified geographic locations while efficiently sharing bandwidth resources with other applications using the same broadcast network. Applications need not be aware of the other applications sharing the resources, nor of the methods, protocols, and other mechanisms used to actually broadcast the data over the broadcast medium. Server-side applications that serve data, send notifications, or distribute events to specific locations within the network use a broadcast location manager. Client applications that receive such data, notifications, or events use a client location filter to obtain events that are relevant based on the location of the device. The broadcast location manager and client location filter work together to reliably and efficiently transmit data, notifications, and events to specific locations over the broadcast network for all applications involved.

Abstract: This disclosure relates to surface mount devices, such as light emitting devices, and methods of manufacture thereof, including recessed contact pads in relation to a mount surface, such that contact bumps and a reflective material are disposed to form a planar mounting surface. Embodiments according to the present disclosure include a light emitting device, wherein the device comprises at a reflective layer, forming at least a portion of a mounting surface. The device also includes one or more contact pads on the device, such that the contact pads are recessed in relation to the reflective layer. Contact bumps are formed on the contact pads, protruding beyond the contact pads, wherein the contact bumps compose at least a portion of the mounting surface. Methods of manufacture including methods utilizing virtual wafer structures are also disclosed.

Abstract: Apparatus and methods for tethering an electrode lead to an anatomical structure within a patient using a coupling member are provided. An anchor configured to be secured to the anatomical structure and an electrode lead suitable for neuromuscular stimulation of spinal muscles and/or nerves innervating one or more muscles that contribute to spine stability may be used. The electrode lead is configured to be coupled to the anchor via the coupling member by securing a first end of the coupling member to the electrode lead and securing a second end of the coupling member to an eyelet of the anchor to place the electrode lead at a desired anatomical site within the patient.

Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

Abstract: An integrated circuit having an external connection pad and an active circuit for generating signals to be output from the integrated circuit by means of the pad, the integrated circuit including an interface circuit associated with the pad, the interface circuit including a latch coupled between the pad and an output of the active circuit, the latch being capable of operating in a first mode in which the state of the pad follows the state of the output of the active circuit and a second mode in which the state of the pad is held by the latch.

Abstract: A method of operating a voltage regulator including a source voltage rail and a plurality of output voltage rails, the method including: converting a source voltage on the source voltage rail to a respective output voltage on each output voltage rail; selecting an output voltage rail; comparing the output voltage on the selected output voltage rail to a reference voltage for the selected output voltage rail; and if the output voltage of the selected output voltage rail is less than the reference voltage for the selected output voltage rail, controlling the voltage regulator to increase the output voltage on the selected output voltage rail, wherein the frequency at which an output voltage rail is selected is dependent upon the rate at which the voltage regulator has previously increased the output voltage on that output voltage rail.

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: A hose shroud (10) comprising a plurality of expanded sections (12) and clamping sections (22), arranged to engage a bundle of hoses or lines, wherein in use, the hose shroud (10) is arranged such that an outer wall (18) of the hose shroud (10) is placed under an inner wall (20) of the hose shroud (10) defining a reservoir (28) therein, the inner wall (20) and outer wall (18) are held in close contact by a plurality of raised protuberances (16) on the outer wall surface (18), the spaced apart inner (20) and outer wall (18) surfaces of the hose shroud (10) are arranged such as to form a lumen (14) to allow fluid communication of fluids leaked within the reservoir (28) and the exterior of the hose shroud (10).

Abstract: Methods and devices are described, including a near-field communications (NFC) or radio frequency identification (RFID) device comprising an NFC or RFID circuit, an antenna having at least a first terminal, a first rectifier connected to the first terminal of the antenna, a switch between the first rectifier and the NFC or RFID circuit, a voltage detector for detecting a voltage in the device caused by a signal received at the antenna, and a control module for controlling the switch, wherein when the voltage exceeds a threshold magnitude, the control module controls the switch to be in an open state and, after a predetermined time period, determines whether the voltage still exceeds the threshold magnitude and, if the voltage still exceeds the predetermined magnitude, controls the switch to be in the open state.

Abstract: Embodiments of the present invention include a system and method for wirelessly identifying and validating an electronic device in order to initiate a communication process with another device or a service. In an embodiment, the system includes a portable biometric monitoring device that is identified by a client device or a server for the purpose of initiating a pairing process. In an embodiment, pairing implies pairing the portable device to an online user account with minimal user interaction. After pairing, the portable device and appropriate client devices and servers communicate with little or no user interaction, for example to upload sensor data collected by the portable device.

Abstract: An illustrative embodiment of a computer-implemented process for scalable group synthesis receives a group definition, applies a sub-set of conditions to the group definition to form a conditioned group definition, receives a set of entities and populates group membership using the received set of entities and the conditioned group definition, wherein each member responds in the affirmative to the sub-set of conditions.

Abstract: A method of controlling an integrated circuit chip including first and second clock sources, the first clock source being more thermally stable and having a higher power consumption, the integrated circuit chip being operable in a first mode in which the first clock source is inactive and the second clock source active and in a second mode in which the first and second clock sources are active, the method including operating the integrated circuit chip in the first mode; taking a measurement indicative of temperature; if the measurement indicates that the temperature is outside of a temperature band: activating the first clock source so as to operate the integrated circuit chip in the second mode; recalibrating the second clock source against the first clock source; and following the recalibration, deactivating the first clock source so as to return the integrated circuit chip to the first mode.

Abstract: An emitter package comprising a light emitting diode (LED) mounted to the surface of a submount with the surface having a first meniscus forming feature around the LED. A matrix encapsulant is included on the surface and covering the LED. The outer edge of the matrix encapsulant adjacent the surface is defined by the meniscus forming feature and the encapsulant forms a substantially dome-shaped covering over said LED. A method for manufacturing an LED package by providing a body with a surface having a first meniscus holding feature. An LED is mounted to the surface with the meniscus holding feature around the LED. A liquid matrix encapsulant is introduced over the LED and the surface, the first meniscus holding feature holding the liquid matrix encapsulant in a dome-shape over the LED. The matrix encapsulant is then cured.

Abstract: Embodiments of the present invention include a system and method for wirelessly identifying and validating an electronic device in order to initiate a communication process with another device or a service. In an embodiment, the system includes a portable biometric monitoring device that is identified by a client device or a server for the purpose of initiating a pairing process. In an embodiment, pairing implies pairing the portable device to an online user account with minimal user interaction. After pairing, the portable device and appropriate client devices and servers communicate with little or no user interaction, for example to upload sensor data collected by the portable device.

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: A method of inhibiting excitotoxicity by indirectly activating ?4?2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed Inhibitors of ?7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate ?4?2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.