Abstract: A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base.

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: Interconnect circuitry for a data processing apparatus is disclosed. The interconnect circuitry is configured to provide data routes via which at least one initiator device may access at least one recipient device.

Abstract: This document describes tools capable of enabling users of mobile communication devices to create communication groups quickly and easily. With such a communication group a user may call, text, or instant message all persons in the group at once by selecting the communication group rather than each person in the group. In one embodiment, the tools enable a user to build a communication group by dragging and dropping indicators for persons he or she knows from one area of a screen into another area. In another embodiment, the tools automatically collect persons from those that the user knows based on one or more criteria. The user may then easily create a communication group of those collected persons, such as by tapping on an area of a mobile device's display.

Abstract: Data may be transmitted in a broadcast mode to multiple devices operating in a network. Efficient utilization of bandwidth while providing a desired level of quality of service is enabled for the applications executing on the devices that utilize the broadcasted data. A set of bandwidth constraints may be utilized in combination with a set of heuristics and rules for the allocation and re-allocation of bandwidth among multiple applications in a manner that minimizes the impact on the quality of service metrics of importance to the affected applications when contention exists for the network resources. Quality of service provided to each application may be degraded smoothly, with certain priorities and guarantees being maintained. Event segmentation and reassembly functions for applications may be provided, as well as reliability mechanisms to increase the ability to provide data to client devices that have not been actively receiving for significant periods of time.

Abstract: A method for carrying out eye surgery comprises a comparison of images recorded before surgery with images recorded during surgery in order to generate a marker which represents a target orientation of an intraocular lens or a difference between a current orientation and the target orientation of the intraocular lens. An eye surgery system respectively comprises an imaging system which is used during a surgery and has a camera, and a diagnostic system which is used before surgery and which also has a camera. The imaging system used during surgery comprises an image processing device in order to perform a computation based on the recorded images, and in order to determine a respective orientation value, from which a representation of a marker representing the target orientation of the intraocular lens is obtained.

Abstract: A method and composition for suppressing replication of the HIV-1 virus strains, modulating the production and liberation of inflammatory mediators; and the prevention and treatment of neurocognitive disorders. The method comprises administering to a subject an effective amount of an a macrocyclic diterpenoid, such as 4R cembranoid.

Abstract: A system for determining radio frequency identification (RFID) performance includes a radio frequency identification (RFID) system having at least one antenna and at least one reader configured to receive an RF indication from an RFID tag and is configured to provide RFID data and an RFID time stamp relating to the at least one antenna. A motion capture video system has at least one camera and a processing system including a recognizable element located proximate to the RFID tag and is configured to provide position data relating to the position of the recognizable element and a motion capture time stamp. An RFID/motion capture system is configured to receive the RFID data, the RFID time stamp, the position data relating to the recognizable element and the motion capture time stamp and to correlate the RFID data and the position data and provide a correlated RFID and motion capture signal.

Abstract: A medication injector apparatus such as an injection pen. The injection pen may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose.

Abstract: Apparatus and methods for rehabilitating a muscle are provided including one or more electrodes configured to be positioned in or adjacent to tissue, one or more sensors configured to sense muscle contraction and to generate a sensor signal based on the muscle contraction, and a pulse generator operatively coupled to the one or more electrodes, e.g., via a lead, and having a controller configured to receive the sensor signal and to adjust the stimulation frequency based on the sensor signal to cause the muscle to contract where muscle contraction is smooth and continuous.

Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

Abstract: Interconnect circuitry is configured to provide data routes via which at least one initiator device may access at least one recipient device. The circuitry including: at least one input for receiving transaction requests from at least one initiator device; at least one output for outputting transaction requests to the at least one recipient device; and at least one path for transmitting transaction requests between at least one input and at least one output. Also includes is control circuitry for routing the received transaction requests from at least one input to at least one output and responds to a barrier transaction request to maintain an ordering of at least some transaction requests with respect to said barrier transaction request within a stream of transaction requests passing along one of said at least one paths. Barrier transaction requests include an indicator of transaction requests whose ordering is to be maintained.

Abstract: An active implantable medical device comprising a therapeutic device, a controller and at least one rechargeable battery, wherein a single hermetically sealed housing encapsulates a therapeutic device, controller and rechargeable battery. A hermetically sealed housing additionally encapsulates a wireless interface and a commutator.

Abstract: The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.

Abstract: A rippled wafer (90) formed of a convoluted wafer ribbon (80), the rippled wafer (90) having an average of at least 12 turns/cm2, wherein a turn is a change in direction of the wafer ribbon (80) of at least 45°, and a confectionery product comprising such a wafer. Also a confectionery product comprising a rippled wafer (90) formed of a convoluted wafer ribbon (80), wherein the turns are substantially uniformly distributed across the cross section of the rippled wafer, where a turn is a change in direction of the wafer ribbon of at least 45°, and a confectionery product comprising a three-dimensional rippled wafer (90) formed in a single step.

Abstract: Apparatus for neuromuscular electrical stimulation and methods for anchoring the same are provided. The apparatus may include an elongated member having one or more electrodes disposed at the distal region of the elongated member and at least one fixation element disposed at the distal region of the elongated member. The fixation element may be shaped and sized to be deployed between tissue layers, such as muscle layers, without damaging the tissue layers so as to secure the one or more electrodes in or adjacent to a desired anatomical site within a patient. An additional fixation element may be disposed at the distal region of the elongated member so that tissue, such as a muscle, may be sandwiched between the fixation elements without damaging the tissue.

Abstract: A method and apparatus for a dynamic service topology. One service is assigned to a virtual machine. The virtual machine is assigned to a physical machine on a network. The service of the virtual machine is transferable from the physical machine to another physical machine on the network by moving the virtual machine.

Abstract: A light emitting diode (LED) package may include a base, at least one light emitting die on the base, and a flextape on the base. The flextape includes at least one metal trace connected to the light emitting die. In a method of manufacturing the LED package, the base may be formed so as to include a basin and at least one light emitting die may be placed within the basin. The flextape may be provided to include at least one metal trace that is electrically connected to the light emitting die.

Abstract: Interconnect circuitry is configured to provide data routes via which at least one initiator device may access at least one recipient device. The circuitry including: at least one input for receiving transaction requests from at least one initiator device; at least one output for outputting transaction requests to the at least one recipient device; and at least one path for transmitting transaction requests between at least one input and at least one output. Also includes is control circuitry for routing the received transaction requests from at least one input to at least one output and responds to a barrier transaction request to maintain an ordering of at least some transaction requests with respect to said barrier transaction request within a stream of transaction requests passing along one of said at least one paths. Barrier transaction requests include an indicator of transaction requests whose ordering is to be maintained.

Abstract: A method and apparatus for managing groups in a directory server is described. In one embodiment, an addition of an identifier of a group to an entry in the directory server is received. A value of an attribute in the entry is updated with the identifier of the group. A content of the group is dynamically changed based on the addition of the identifier of the group to the entry in the directory server.