Abstract: A method of inhibiting excitotoxicity by indirectly activating ?4?2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed. Inhibitors of ?7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate ?4?2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.

Abstract: A method of inhibiting excitotoxicity by indirectly activating ?4?2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed. Inhibitors of ?7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate ?4?2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.

Abstract: Apparatus 10 for detecting inadequate maintenance of a system 12 of an aircraft or other vehicle is provided. The apparatus comprises: computer readable medium or media 14 configured to store data 18 relating to operation or non-operation of the system 12 over a period of time; and a data processing unit 16 configured to evaluate the data to identify at least one event indicative of the inadequate maintenance of the system.

Abstract: Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.

Abstract: The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.

Abstract: A method of inhibiting excitotoxicity by indirectly activating ?4?2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed Inhibitors of ?7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate ?4?2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.

Abstract: A method of inhibiting excitotoxicity by indirectly activating ?4?2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed. Inhibitors of ?7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate ?4?2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.

Abstract: A method of inhibiting excitotoxicity by indirectly activating ?4?2 nicotinic acetylcholine receptors (nAChRs) which indirectly activate synaptic AMPA and NMDA receptors is disclosed Inhibitors of ?7 nACHRs, such as macrocyclic diterpenoids, more specifically cembranoids or methyllycaconitine (MLA), indirectly activate ?4?2 nAChRs and can be used to treat neurodegenerative diseases, including, but not limited to, Alzheimer's Disease, Parkinson Disease, AIDS related dementia and the delayed effects of stroke. They can also be used to treat diseases associated with neuronal impairment, including, but not limited to glaucoma caused by optical nerve damage, delayed effects of epilepsy; and multiple sclerosis.

Abstract: A server-client system or architecture that allows datacast applications to reliably transport data objects from a network server over a unidirectional packet network (“datacast network”) to one or more clients, each of which may be listening to the packet stream at different times. The invention allows the clients to listen intermittently to the datacast, yet still receive all of the data objects published by the server in a timely manner, and in a way that is more optimal in terms of client resource use. This ensures that listening clients can receive a complete set of the data objects broadcast while being able to conserve client processing and power resources by not requiring continuous listening by the client to the datacast.

Abstract: Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.

Abstract: The present invention relates to a battery separator, comprising fibers of the lyocell genus, wherein said lyocell fibers are mercerised. The present invention furthermore relates to novel lyocell fibers useful for battery separators, as well as batteries comprising the inventive battery separator.

Abstract: The invention relates to a novel method for producing bacterial or viral saccharides, such as capsular, immunogenic or membrane saccharides, in a plant cell. Also provided plants, plant cells, plant parts, and plant products comprising such a bacterial or viral saccharide. The invention is based upon the novel finding that bacterial enzymes can be used in a plant cell to produce bacterial or viral capsular, immunogenic and/or membrane saccharides.

Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

Abstract: A power management system comprises a remotely operated vehicle (ROV), a tether management system (TMS), and an umbilical operatively in communication with the TMS external electrical power interface and the TMS-to-ROV umbilical interface. The system can be configured to provide electrical power management that moves some or all of the electrical power required for ROV propulsion and tooling to the ROV and/or TMS, and maximizes available power and manages loads across all systems as necessary and by priority. Power management may also be required that features intelligent routing of power to subsystems and integration of variable frequency drives (VFDs).

Abstract: A communication device comprising: a first radio capable of communicating according to a first protocol and having a set of operational modes; and a second radio capable of communicating according to a second protocol, the communication device being configured to, in dependence on one or more communications by the second radio in accordance with the second protocol, selecting one mode of operation for the first radio from the set of operational modes, wherein said one or more communications comprises: sending a first message; and a response or non-response to the first message.

Abstract: A system-on-check integrated circuit 2 includes interconnect circuitry 4 connecting a plurality of transaction sources to a plurality of transaction destinations. The interconnect circuitry 4 includes a reorder buffer for buffering access transactions and hazard checking circuitry 46, 48, 50, 52 for performing hazard checks, such as point-of-serialisation checks and identifier reuse checks. Check suppression circuitry 62, 64, 66, 68 serves to suppress one or more hazard checks depending upon one or more state variables that themselves depend upon access transactions other than the access transaction for which the hazard checking is or is not to be suppressed. As an example, hazard checking may be suppressed if it is known that there are no other access transactions currently buffered within the reorder buffer 26 or alternatively no other access transactions from the same transaction source buffered within the reorder buffer 26.

Abstract: Methods, devices, and computer programs are presented for creating a unified data stream from multiple data streams acquired from multiple devices. One method includes an operation for receiving activity data streams from the devices, each activity data stream being associated with physical activity data of a user. Further, the method includes an operation for assembling the unified activity data stream for a period of time. The unified activity data stream includes data segments from the data streams of at least two devices, and the data segments are organized time-wise over the period of time.

Abstract: Methods, devices, and computer programs are presented for creating a unified data stream from multiple data streams acquired from multiple devices. One method includes an operation for receiving activity data streams from the devices, each activity data stream being associated with physical activity data of a user. Further, the method includes an operation for assembling the unified activity data stream for a period of time. The unified activity data stream includes data segments from the data streams of at least two devices, and the data segments are organized time-wise over the period of time.

Abstract: Embodiments of the present invention include a system and method for wirelessly identifying and validating an electronic device in order to initiate a communication process with another device or a service. In an embodiment, the system includes a portable biometric monitoring device that is identified by a client device or a server for the purpose of initiating a pairing process. In an embodiment, pairing implies pairing the portable device to an online user account with minimal user interaction. After pairing, the portable device and appropriate client devices and servers communicate with little or no user interaction, for example to upload sensor data collected by the portable device.

Abstract: Examples disclose a system with an input current sensing circuit to measure an input current of a current carrier. Additionally, the examples disclose an output sensing circuit to measure an output current from the current carrier. Further, the examples disclose a controller to determine a power loss associated with the current carrier based on the input and the output current measurements. The power loss indicates a risk of a thermal damage to the current carrier.