Abstract: The path selection and wavelength assignment to a selected path are performed by mapping the wavelength reach to the demand distribution (agile reach) resulting in a 50-60% increase in the network reach. The network reach is further increased (about 2.2 times) when on-line measured performance data are used for path selection and wavelength assignment. The connections may be engineered/upgraded individually, by optimizing the parameters of the entire path or of a regenerator section of the respective path. The upgrades include changing the wavelength, adjusting the parameters of the regenerator section, controlling the launch powers, mapping a certain transmitter and/or receiver to the respective wavelength, selecting the wavelengths on a certain link so as to reduce cross-talk, increasing wavelength spacing, etc.

Abstract: A power inverter is provided for converting DC power into AC power. The inverter may be operable to couple to two or more transformer modules each operable to convert at least a portion of the DC power to at least a portion of the AC power. In one embodiment, two or more transformer modules are removably coupled to the inverter. In an alternative embodiment, the inverter is capable of electrically coupling to an externally-housed transformer module. In an alternative embodiment, the inverter may include two or more transformer modules hard-wired into the device. The inverter may include an AC safety plug for releasably connecting to an AC power network and outputting AC power. The inverter may include one or more sensors configured to detect one or more properties of the AC power network for the purposes of determining whether a connection to the power network should be established.

Abstract: A method for the treatment of an aqueous stream containing both anionic and cationic species is provided. The method comprises the following steps. Circulating water continuously through an essentially closed loop, the loop incorporating an ion adsorption unit which, in turn, comprises a water permeable layer of an ion adsorbing material. Feeding an aqueous solution containing the anionic and the cationic species to the essentially closed loop. Passing the circulating water, including the aqueous solution containing the ionic and the cationic species, through the ion adsorbing material in the ion adsorption unit in a continuous manner. While at the same time applying an electric potential across the thickness of the layer of ion adsorbing material and removing from the ion adsorption unit more concentrated aqueous solutions of the separate ionic species. Discharging each of the aqueous solutions from the ion adsorption unit.

Abstract: The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNAs or families and, clusters capable of targeting multiple oncogenic pathways.

Abstract: A movable platform has a front end, a back end, a longitudinal axis, and at least one axle oriented generally transverse to the longitudinal axis and located between the front and back ends for supporting wheels of the platform. A position sensor is affixed on the platform at a location other than at a location defined by a plane passing through the axle and normal to the longitudinal axis. The position sensor provides position data as the platform traverses a path. A sensor arrangement is supported by the platform and configured to provide subsurface sensor data as the platform traverses the path. A processor is configured to associate the position data with the sensor data relative to a reference frame and in a manner that accounts for dynamic motion of the platform.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: Embodiments of the invention are generally directed to adaptive interconnection for multimedia devices. An embodiment of an apparatus includes an apparatus that includes one or more ports, the one or more ports including one or more adaptable ports, where each adaptable port includes a receptacle to accept a plug of a connector element, the receptacle including multiple electrical contacts. The apparatus further includes an adaptable port device to process data including multimedia data received at the one or more adaptable ports, where the adaptable port device is to detect a multimedia signal format for multimedia data received at each of the adaptable ports, and adapt each of the adaptable ports to be compatible with the detected multimedia signal format for the adaptable port.

Abstract: Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: Transmission of alternative content over standard device connectors. An embodiment of a method includes connecting a first device to a second device utilizing a standard connector, the connector including multiple pins, and detecting whether the second device is operating in a standard mode or an alternative mode. If the second device is operating in the alternative mode, then switching one or more pins of the standard connector for the alternative mode and transmitting or receiving signals for the alternative mode via the plurality of pins of the standard connector.

Abstract: A helicopter rotor damper system including a torsional damper with a damper centering bearing providing a damper center of rotation axis, a first elastomeric torsional damper with a first elastomeric torsional damper torsional elastomer bonded between a first elastomeric torsional damper first torsional damper nonelastomeric bonding surface and a first elastomeric torsional damper second torsional damper nonelastomeric bonding surface, and a second elastomeric torsional damper with a second elastomeric torsional damper torsional elastomer bonded between a second elastomeric torsional damper first torsional damper nonelastomeric bonding surface and a second elastomeric torsional damper second torsional damper nonelastomeric bonding surface.

Abstract: A rack for carrying skis and snowboards on top of a vehicle includes a pair of clamp devices equipped for mounting on a pair of crossbars. Each clamp device has a collapsible position which reduces its forward facing profile when not being used to carry cargo items.

Abstract: A measurement circuit measures a first power consumption value corresponding to a first configuration of a component of a computing device and a second power consumption value corresponding to a second configuration of the component. A user interface module provides a the first power consumption value for the first configuration and the second power consumption value for the second configuration. A user selection indicating one of the first configuration and the second configuration is received and a configuration module implements the configuration indicated by the user selection in the component.

Abstract: A system for consistently emitting a volatile material includes a volatile material dispenser having a diffusion element. The system further includes a refill adapted for disposal within the volatile material dispenser and including a container having a volatile material disposed therein and a wick having a first end disposed in contact with the volatile material in the container and a second end extending out of the container. A time constant for (Parameter 4) for the system is less than or equal to about 1.0 hour when estimated using the equation: Predicted mass change=Parameter4+(Parameter3*T)+(Parameter2*exp(?T/Parameter1)).

Abstract: Disclosed are methods and kits for genome-wide methylation of GpC sites and for genome-wide chromatin structural determination. Specifically, the methods and kits of the present invention make possible the simultaneous determination of endogenous DNA methylation state and chromatin architecture across the entire genome.

Abstract: Biochemical assay apparatus uses a container with a sleeve of electrically-conductive material (300) to heat it. The heating is done inside a chamber and a contactless heat sensor (110) such as a thermopile or a bolometer, also inside the chamber, is used to monitor the temperature of the electrically conductive material (300). There are many factors that distort the output of the heat sensor (110), particularly as the temperature rises and properties such as emissivity change, or as time goes by and tarnishing and dust affect the heat sensor output. Because the sleeve has low thermal mass and heat transfer only has to happen over short distances, it is relatively easy to calculate a change in actual temperature of the electrically conductive material (300) when subjected to a known pulse of drive current and this property can be used to calibrate the performance of the heat sensor (110) in situ in the chamber.

Abstract: A movable platform has a front end, a back end, a longitudinal axis, and at least one axle oriented generally transverse to the longitudinal axis and located between the front and back ends for supporting wheels of the platform. A position sensor is affixed on the platform at a location other than at a location defined by a plane passing through the axle and normal to the longitudinal axis. The position sensor provides position data as the platform traverses a path. A sensor arrangement is supported by the platform and configured to provide subsurface sensor data as the platform traverses the path. A processor is configured to associate the position data with the sensor data relative to a reference frame and in a manner that accounts for dynamic motion of the platform.

Abstract: In an aspiration flow measurement system, a flow channel is provided for receiving an aspiration fluid flow therethrough. The flow measurement system further includes an aspiration flow measurement chamber and a flow sensor that is configured to generate a raw signal indicative of the rate of fluid flow through the flow channel. A control system is configured to monitor the signals indicating the flow through the flow measurement chamber, and to determine when a value of the raw signal is indicative of a disruption caused by the presence of an air bubble, wherein the control system generates a filtered signal of the flow rate that is exclusive of any signal values that are indicative of a disruption.

Abstract: Methods and systems are disclosed to facilitate holistic management of different types of IT resources within and work associated with an IT infrastructure. In one example, a method includes defining a number of parameters related to IT resources, associating an IT resource with at least one of the parameters, and aggregating a number of IT resources as an IT infrastructure. Each of the IT resources of the IT infrastructure is associated with at least one of the parameters. In another example, a method includes defining a number of parameters related to a number of different types of IT resources, associating two or more of the parameters with one another, and aggregating the parameters in an IT resource definitional structure by which any one of the types of IT resources can be defined by associating the IT resource with at least one of the parameters.

Abstract: A computer system provides a plug-in architecture for creation of a dynamic font. The computer system can incorporate a new filter function into a filtering layer of a font program. The filtering layer includes pre-defined filter functions to transform a base font into a new font. The computer system applies one or more font rules in the filtering layer to the base font. The font rules are implemented by the new filter function and at least one of the pre-defined filter functions to randomize an appearance of each character in a character string. The character string rendered with the new font has a dynamic and randomized appearance.