Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: This invention is designed to provide a solution to a problem that exists when considering how to present a gift predominantly to a child. This is a plastic modular frame that is easily erected and fits over an assembled, tested and/or unusual shaped gift. By creating the cubic frame, it becomes easy to attach standard gift wrapping paper to the frame and conceal the gift inside. Rods and connecting spigots have a unique triangular profile and being produced in plastic are reusable to the consumer. Attached drawings show an assembled frame (FIG. 9) together with drawings of each of the main components; corner piece, adaptor and rod profile (FIGS. 1 to 8). See paragraph 0010 for full description of each drawing.

Abstract: In an aspiration flow measurement system, a flow channel 108 is provided for receiving an aspiration fluid flow therethrough. The flow measurement system further includes an aspiration flow measurement chamber 102 and a flow sensor that is configured to generate a raw signal indicative of the rate of fluid flow through the flow channel 102. A control system 200 is configured to monitor the signals indicating the flow through the flow measurement chamber 102, and to determine when a value of the raw signal 250 is indicative of a disruption caused by the presence of an air bubble, wherein the control system 200 generates a filtered signal 260 of the flow rate that is exclusive of any signal values that are indicative of a disruption.

Abstract: An air bubble separator is provided for ophthalmic surgical systems, which includes a housing 102 having a diagonally-oriented flow channel 110 and a vertically-oriented flow channel 130 adjoining the diagonally oriented channel. The diagonally-oriented flow channel 110 has a downstream portion 112 disposed downstream of the vertically-oriented flow channel 130, and an upstream portion 118 disposed upstream of the vertically-oriented flow channel 130. The downstream portion 112 of the diagonally-oriented flow channel 110 has a cross-sectional area 114 that is greater than that of the upstream portion 118. The downstream portion's cross-sectional area 114 is greater than the upstream portion's cross-sectional area 124 by an amount or percentage that is sufficient to slow fluid flow through the diagonally-oriented flow channel 110, so as to cause air within the fluid to rise and flow into the vertically-oriented flow channel 130.

Abstract: A flow measurement device 100 is provided that includes an electrode terminal chamber 102 with an inlet 104 in communication with a flow channel 108 for receiving fluid and viscoelastic material aspirated from a surgical site, and an outlet 106 that tapers into a flow channel 108. The outlet 108 has a taper angle that is sufficient to smooth flow and cause viscoelastic material entering the electrode terminal chamber 102 to flow substantially within a center portion of the chamber and through the outlet 106. The electrode terminal chamber 102 further includes first and second electrode terminals 130 and 140 disposed on generally opposite sides of the electrode terminal chamber 102 in a spaced-apart manner. The first and second electrode terminals 130 and 140 are positioned a distance from the center of the chamber 102 that is sufficient to substantially avoid contact between the terminals and viscoelastic materials flowing through the chamber 102.

Abstract: The present invention provides a surgical system 10 a source of irrigation fluid 20, a collection cassette 30, a handpiece 50 applied to a surgical area for infusing irrigation fluid and for aspirating a biological material, first and second conduits (60 and 62) connecting the handpiece 50 to each of the source of irrigation fluid 20 and the collection cassette 30, a monitoring device 70 and means for trapping materials 80 that cause signal disruption to the monitoring device 70.

Abstract: This invention relates to the assessment of individuals with first-episode psychosis (FEP) or an at risk mental state (ARMS) using visuospatial associative learning tests such as paired associates learning (PAL). Visuospatial associative learning ability as determined by such tests may be prognostic of the severity of psychosis in FEP patients and diagnostic of psychosis in ARMS patients.

Abstract: Particular embodiments provide novel and clinically useful DNA methylation predictors of hormone receptor status, and predictors of response to endocrine (e.g., hormonal) and non-endocrine breast cancer therapy. The ESR1 gene, encoding the estrogen receptor (ER) alpha proved to be the preferred predictor of progesterone receptor (PR) status, while methylation of the PGR gene, encoding PR, was the preferred predictor of ER status. ESR1 methylation outperformed hormone receptor status as a predictor of clinical response in patients treated with antiestroges (e.g., tamoxifen), while promoter methylation of the CYP1B1 gene, encoding a tamoxifen and estradiol metabolizing cytochrome P450, predicted response differentially in tamoxifen-treated and non-treated patients. High levels of promoter methylation of the ARHI gene, encoding a RAS-related small G-protein, were shown to be preferred predictors of better survival in patients who had not received tamoxifen therapy.

Abstract: A helicopter rotor damper system including a torsional damper with a damper centering bearing providing a damper center of rotation axis, a first elastomeric torsional damper with a first elastomeric torsional damper torsional elastomer bonded between a first elastomeric torsional damper first torsional damper nonelastomeric bonding surface and a first elastomeric torsional damper second torsional damper nonelastomeric bonding surface, and a second elastomeric torsional damper with a second elastomeric torsional damper torsional elastomer bonded between a second elastomeric torsional damper first torsional damper nonelastomeric bonding surface and a second elastomeric torsional damper second torsional damper nonelastomeric bonding surface.

Abstract: An apparatus for providing board level shielding of Electromagnetic Interference in a printed circuit board is disclosed. The apparatus includes a plastic part, a metal conformal coating and a form-in-place Electromagnetic Interference gasket. The plastic part is configured in one or more compartments to provide an enclosure, and is attached to the printed circuit board. The metal conformal coating is applied continuously to one or more surfaces of the plastic part. The form-in-place Electromagnetic Interference gasket is applied on top of the metal conformal coating in an area of a part flange.

Abstract: Apparatus is described for removing ionisable impurities from an electrolyte solution in an electromembrane device. The apparatus comprises means for recirculating the electrolyte solution between the cathode and the anode, and means for transferring selected ions from the electrolyte solution into a separate stream upon application of a current.

Abstract: The present invention is related to methods of treating viral and protozoan infections in mammals using antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein.

Abstract: A fluid-elastomeric damper assembly operable for damping relative motion between a first structure and a second structure including a housing structure grounded to the first structure and a plurality of elastomer seals coupled to the housing structure, the housing structure and the plurality of elastomer seals defining a fluid-elastomeric chamber operable for containing a fluid. The fluid-elastomeric damper assembly also including one or more piston structures disposed within the housing structure and the fluid-elastomeric chamber, the one or more piston structures grounded to the first structure and driven by the second structure, and the one or more piston structures each including a first substantially fluid-filled chamber and a second substantially-fluid-filled chamber in communication via an orifice, the first substantially fluid-filled chamber and the second substantially fluid-filled chamber also in communication with the fluid-elastomeric chamber.

Abstract: A decision engine is provided that integrates all components of a credit application process, including access to and manipulation of credit bureau data, credit scoring, credit decisioning, and matching the correct products, into a single application service provider (ASP) platform which is accessible through a series of Application Programming Interfaces (APIs).

Abstract: Compounds represented by the formula where R1, R2, R3, R4, R5, and Q are as defined herein, exhibit activity against infectious pathogens.

Abstract: Antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein.

Abstract: A client requests an object at a first server in a content delivery network (CDN), the request having been directed to said first server regardless of whether the first server has the requested object; When the first server does not have a copy of the requested object, it selectively replicating the requested object on the first server. The replicating is based at least in part on a measure of popularity of the requested object, wherein the requested object is not replicated to the first server when the measure of popularity of the requested object does not exceed a popularity threshold.

Abstract: The invention provides a rotary damper for controlling helicopter motions. The rotary damper includes an outer canister with an inner paddle wheel receiving cavity which receives an inner paddle wheel with upper and lower elastomeric tubular intermediate members between the inner paddle wheel and the outer canister. The canister and inner paddle wheel form neighboring variable volume chambers in liquid communication through liquid damping conduits.

Abstract: A content delivery method directs a request by a client for an object to a first server in a content delivery network (CDN), regardless of whether the first server has the requested object. If the first server has the requested object, then it is served to the client from the first server; otherwise, the first server redirects the client request to a second server in the CDN to handle the request. The second server may be a peer server of the first server. The first and second servers may be edge servers in the CDN.