Abstract: A tonneau system for a vehicle bed includes a rail disposed on a top portion of the vehicle bed. A tonneau cover extends over the vehicle bed and includes an elongate retention clip is adjacent the rail and is connected thereto by an interference fit. The elongate retention clip includes a removal tab. A connection clip is slidable along the linear extent of the rail. An elongate band is slidably received in the tonneau cover and in a band aperture of the connection clip.

Abstract: A method of treating a liquid waste containing target species is described, in which the liquid is first conveyed through a housing containing a catalyst for removing either a reducing agent or an oxidising agent from the liquid, The liquid is then conveyed to a reverse osmosis or nanofiltration membrane to obtain a retentate rich in the target species and a permeate lean in the target species. The retentate is returned to the liquid upstream from the membrane, whilst the permeate may be subject to further treatment, for example in a neutralisation plant.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: In a method of treating a gas stream, an aqueous scrubbing liquor is circulated through an essentially closed loop (20) comprising an electrochemical unit (48) for reducing the acidity of the liquor. A portion of the circulating liquor is diverted away from the closed loop (20) to a gas scrubbing unit (10). The gas stream enters the scrubbing unit (10), wherein an acid, for example HF and solid particulates, for example SiO2 particulates, within the gas stream dissolve in the diverted liquor. The diverted liquor is subsequently returned to the closed loop (20), and is replenished in the scrubbing unit (10) by fresh liquor diverted from the closed loop (20). A device (46) is provided for monitoring the acidity of the liquor at a location within the closed loop (20). The reduction in the acidity of the liquor by the electrochemical cell (48) is controlled depending on the monitored concentration.

Abstract: An air bubble separator is provided for ophthalmic surgical systems, which includes a housing 102 having a diagonally-oriented flow channel 110 and a vertically-oriented flow channel 130 adjoining the diagonally oriented channel. The diagonally-oriented flow channel 110 has a downstream portion 112 disposed downstream of the vertically-oriented flow channel 130, and an upstream portion 118 disposed upstream of the vertically-oriented flow channel 130. The downstream portion 112 of the diagonally-oriented flow channel 110 has a cross-sectional area 114 that is greater than that of the upstream portion 118. The downstream portion's cross-sectional area 114 is greater than the upstream portion's cross-sectional area 124 by an amount or percentage that is sufficient to slow fluid flow through the diagonally-oriented flow channel 110, so as to cause air within the fluid to rise and flow into the vertically-oriented flow channel 130.

Abstract: The path selection and wavelength assignment to a selected path are performed by mapping the wavelength reach to the demand distribution (agile reach) resulting in a 50-60% increase in the network reach. The network reach is further increased (about 2.2 times) when on-line measured performance data are used for path selection and wavelength assignment. The connections may be engineered/upgraded individually, by optimizing the parameters of the entire path or of a regenerator section of the respective path. The upgrades include changing the wavelength, adjusting the parameters of the regenerator section, controlling the launch powers, mapping a certain transmitter and/or receiver to the respective wavelength, selecting the wavelengths on a certain link so as to reduce cross-talk, increasing wavelength spacing, etc.

Abstract: Transmission of alternative content over standard device connectors. An embodiment of a method includes connecting a first device to a second device utilizing a standard connector, the connector including multiple pins, and detecting whether the second device is operating in a standard mode or an alternative mode. If the second device is operating in the alternative mode, then switching one or more pins of the standard connector for the alternative mode and transmitting or receiving signals for the alternative mode via the plurality of pins of the standard connector.

Abstract: The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.

Abstract: Described herein is a method and apparatus for generating automatic language bindings. The method includes receiving a request for a first program module in a first language from a second program in a second language. A binding module is created in the second language in response to the request, where the binding module is generated from debug data of the first program module. The the binding module is returned to the second program module. The second program module can then access the functionality of the first program module through use of the functions of the binding module.

Abstract: There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to their methylation pattern in human cancers including, but not limited to those of bladder and prostate. These 103 sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer, and as reagents in kits for detecting methylated CpG-containing nucleic acids.

Abstract: There is disclosed a cancer diagnostic method based upon DNA methylation differences at specific CpG sites. Specifically, the inventive method provides for a bisulfite treatment of DNA, followed by methylation-sensitive single nucleotide primer extension (Ms-SNuPE), for determination of strand-specific methylation status at cytosine residues.

Abstract: In an automatically switched optical network operating according to a wavelength plan, the wavelengths are assigned to an optical path based on availability, performance and SRS wavelength coupling reduction. First, the wavelengths are grouped in static bins based on their reach versus cost performance, and each bin assumes a ?Q of a middle wavelength. Then, the bins are moved into subsets of dynamic bins, constructed using bin constraints that account for the particulars of the respective optical path. The path is characterized taking into account the wavelength currently accessing at the end nodes, and the wavelength tandeming through the end nodes. Wavelength selection starts with the bins that satisfy the maximum number of constraints, and the wavelengths are checked sequentially against wavelength constraints; relaxed constraints are also applied when it is not possible to exactly satisfy one or more constraints.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: In an automatically switched optical network operating according to a wavelength plan, the wavelengths are assigned to an optical path based on availability, performance and SRS wavelength coupling reduction. First, the wavelengths are grouped in static bins based on their reach versus cost performance, and each bin assumes a ?Q of a middle wavelength. Then, the bins are moved into subsets of dynamic bins, constructed using bin constraints that account for the particulars of the respective optical path. The path is characterized taking into account the wavelength currently accessing at the end nodes, and the wavelength tandeming through the end nodes. Wavelength selection starts with the bins that satisfy the maximum number of constraints, and the wavelengths are checked sequentially against wavelength constraints; relaxed constraints are also applied when it is not possible to exactly satisfy one or more constraints.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formula I, II, or III) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: This invention is designed to provide a solution to a problem that exists when considering how to present a gift predominantly to a child. This is a plastic modular frame that is easily erected and fits over an assembled, tested and/or unusual shaped gift. By creating the cubic frame, it becomes easy to attach standard gift wrapping paper to the frame and conceal the gift inside. Rods and connecting spigots have a unique triangular profile and being produced in plastic are reusable to the consumer. Attached drawings show an assembled frame (FIG. 9) together with drawings of each of the main components; corner piece, adaptor and rod profile (FIGS. 1 to 8). See paragraph 0010 for full description of each drawing.

Abstract: In an aspiration flow measurement system, a flow channel 108 is provided for receiving an aspiration fluid flow therethrough. The flow measurement system further includes an aspiration flow measurement chamber 102 and a flow sensor that is configured to generate a raw signal indicative of the rate of fluid flow through the flow channel 102. A control system 200 is configured to monitor the signals indicating the flow through the flow measurement chamber 102, and to determine when a value of the raw signal 250 is indicative of a disruption caused by the presence of an air bubble, wherein the control system 200 generates a filtered signal 260 of the flow rate that is exclusive of any signal values that are indicative of a disruption.

Abstract: An air bubble separator is provided for ophthalmic surgical systems, which includes a housing 102 having a diagonally-oriented flow channel 110 and a vertically-oriented flow channel 130 adjoining the diagonally oriented channel. The diagonally-oriented flow channel 110 has a downstream portion 112 disposed downstream of the vertically-oriented flow channel 130, and an upstream portion 118 disposed upstream of the vertically-oriented flow channel 130. The downstream portion 112 of the diagonally-oriented flow channel 110 has a cross-sectional area 114 that is greater than that of the upstream portion 118. The downstream portion's cross-sectional area 114 is greater than the upstream portion's cross-sectional area 124 by an amount or percentage that is sufficient to slow fluid flow through the diagonally-oriented flow channel 110, so as to cause air within the fluid to rise and flow into the vertically-oriented flow channel 130.