Abstract: A cleaner head for a cleaning appliance, comprising a brushbar, a housing defining a chamber which at least partially surrounds the brushbar, the chamber having a dirty air inlet and a dirty air outlet, and a scraper having a working edge which extends in the longitudinal direction of the brushbar. The scraper is arranged such that, in use, the working edge scrapes debris entrained by the brushbar from the brushbar. The working edge has a profile which is shaped such that debris which accumulates at the working edge is drawn by the airflow through the cleaner head along the working edge towards the dirty air outlet.

Abstract: A process for the production of an ester product from a mixture of at least two different ester compounds includes the steps of mixing together at least two different starting ester compounds to form a first ester mixture; and contacting the first ester mixture with a catalyst including from 30-60% of calcium oxide and at least one second metal oxide at a temperature of at least 180° C., for a duration of at least one hour, with mixing, to form a second ester mixture having a melting point which is lower than the melting point of the first ester mixture.

Abstract: A system for providing continuous automated verification of user identity and intent includes a processor within at least one server that implements a first processing node and a second processing node for monitoring a mirrored live-data flow of a live-data flow passing through the first processing node in a non-intrusive manner that does not affect the live-data flow passing through the first processing node to detect relevant network access and activity in the mirrored live data flow. At the second processing node, a first set of verification criteria, comprising a first set of dynamically generated dialog of questions with associated answers to be provided by the at least one user, are dynamically generated based on live data inputs from the mirrored live-data flow and external data sources to verify an identify and an activity of the at least one user attempting to access the network prior to access and performing an activity on the network.

Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and the CDK inhibitor dincaciclib, and the use of the combination therapies for the treatment of cancer, and in particular for treating cancers that express PD-L1.

Abstract: A method for detecting and intercepting at least one of fraud, security breach, intrusion or misuse of network resources monitors at least one of a plurality of simultaneous live data flows that are in active transmission between a first endpoint and a second endpoint in a network prior to the storage of data within the live data flows in a database, to take action to control the operation of a network. Prescribed detection algorithms are updated for detecting prescribed patterns and deduced detection algorithms are updated for detecting deduced patterns within the plurality of simultaneous live data flows with at least one of live data conditions and external data sources. The deduced and prescribed patterns that indicate occurrence of at least one of fraud, security breach, intrusion or misuse of the network are detected from at least one of the live data flows and the external data sources using the prescribed detection algorithms and the deduced detection algorithms.

Abstract: The present invention concerns a eukaryotic host selected from microorganisms, and a method for producing glycolic acid using said eukaryotic host cells, especially cells of a genetically modified fungal host. Further this invention relates to a glycolic acid product obtained using the method described here and the use of genetically modified microorganism cells in production of glycolic acid.

Abstract: A drink for moderating blood glucose levels produced by a meal in a human subject suffering diabetes or impaired glucose tolerance (IGT) the drink comprising: at least one water soluble or water dispersible compound selected from the group consisting of amino acids, peptides and proteins in a total amount of at least 8g on a dry weight basis per serving of drink; aqueous liquid in an amount of from 70 ml to 400 ml (preferably in an amount of from 100 ml to 250 ml and more preferably from 125 ml to 175 ml) per serving, and wherein the drink exhibits shear banding when subject to the shear banding test herein described.

Abstract: The present invention is directed to Compounds of Formula (I) and salts thereof, wherein R1, R2, R3 and R4 are defined above herein. The present invention is also directed to uses of the compounds of Formula (I) to add phosphoramidate groups onto organic alcohols.

Abstract: A method of preparing wood for packing comprises: loading wood lengthwise into a conveyor system; conveying the wood pieces one-by-one onto a loading hatch in a predetermined orientation; when a wood piece is fully on the loading hatch, opening the loading hatch and dropping the wood piece in the predetermined orientation into a measuring compartment; repeating the conveying and dropping process so that multiple wood pieces are stacked in the same orientation in the measuring compartment; and, when a required amount of stacked wood is within the measuring compartment, dropping the stacked wood pieces into a packing area.

Abstract: A system for providing continuous automated verification of user identity and intent includes a processor within at least one server that implements a first processing node and a second processing node for monitoring a mirrored live-data flow of a live-data flow passing through the first processing node in a non-intrusive manner that does not affect the live-data flow passing through the first processing node to detect relevant network access and activity in the mirrored live data flow. At the second processing node, a first set of verification criteria, comprising a first set of dynamically generated dialogue of questions with associated answers to be provided by the at least one user, are dynamically generated based on live data inputs from the mirrored live-data flow and external data sources to verify an identify and an activity of the at least one user attempting to access the network prior to access and performing an activity on the network.

Abstract: A system and method monitors for fraudulent transactions relating to a mobile device. Either of first and second processing nodes places a hold on a transaction associated with the first live-data flow and the second live-data flow responsive to detection of a potentially fraudulent condition. A third processing node generates an interactive verification communication responsive to the first data associated with the first live-data flow and the second data associated with the second live-data flow to establish a validity of the transaction. The third processing node releases the hold on the transaction responsive to the interactive verification communication determining the potentially fraudulent condition relates to a non-fraudulent transaction and generates a fraud detection response responsive to the interactive verification communication determining the potentially fraudulent condition relates to a fraudulent transaction before the transaction completes.

Abstract: A system for assessing blood circulation in a subject's limb, including detection means for detecting a signal dependent upon the arterial blood volume in a limb of the subject when the subject is in a first posture and also when the subject is in a second posture, different to the first posture; and processing means for calculating a quantitative indicator that is dependent upon the ratio of the signal for the first posture to the signal for the second posture.

Abstract: Non-limiting examples of the present disclosure describe low latency pre-web classification of query data. In examples, processing is performed where query data may be analyzed in a low latency manner that includes providing a vertical intent classification and entity identification for query data before a web ranking service processes the query data. Query data may be received. A vertical intent classification index may be searched using the query data. In examples, the vertical intent classification index may comprise a set of files that can be used to determine one or more candidate entity identifiers for the query data. The one or more entity identifiers may be ranked. The query data, a vertical intent classification for the vertical intent classification index and the one or more ranked candidate entity identifiers may be transmitted for processing associated with a web ranking service. Other examples are also described.

Abstract: In some implementations, a system obtains activity data for a sump pump associated with a property where the obtained activity data indicates a present operational status of the sump pump. The system obtains water level data associated with the property where the water level data indicates a level of water within the property, determines that the activity data indicates that the sump pump is operating and that the water level within the property satisfies a water level risk threshold, and, in response to the determination that the activity data indicates that the sump pump is operating and that the water level within the property satisfies a water level risk threshold, provides a notification that the property is at risk of suffering water damage.

Abstract: A drink for moderating blood glucose levels produced by a meal in a human subject suffering diabetes or impaired glucose tolerance (IGT) the drink comprising: at least one water soluble or water dispersible compound selected from the group consisting of amino acids, peptides and proteins in a total amount of at least 8g on a dry weight basis per serving of drink; aqueous liquid in an amount of from 70 ml to 400 ml (preferably in an amount of from 100 ml to 250 ml and more preferably from 125 ml to 175 ml) per serving, and wherein the drink exhibits shear banding when subject to the shear banding test herein described.

Abstract: Most spinal cord therapies are administered systemically, with only a small portion of the therapeutic reaching the spinal cord. A novel method for delivering therapeutics directly to the spinal cord is provided. The method uses a duel-balloon catheter to isolate the microvasculature around a region of the spinal cord. Once isolated, one or more therapeutics are delivered directly to the spinal cord blood supply. This allows for smaller, safer therapeutic does to be utilized.

Abstract: A drink for moderating blood glucose levels produced by a meal in a human subject suffering diabetes or impaired glucose tolerance (IGT) the drink comprising: at least one water soluble or water dispersible compound selected from the group consisting of amino acids, peptides and proteins in a total amount of at least 8 g on a dry weight basis per serving of drink; aqueous liquid in an amount of from 70 ml to 400 ml (preferably in an amount of from 100 ml to 250 ml and more preferably from 125 ml to 175 ml) per serving, and wherein the drink exhibits shear banding when subject to the shear banding test herein described.

Abstract: We describe a control and monitoring system and method for access to a restricted area, such as mass transport systems (subways, trains, airports, ships and others), commercial buildings, schools, factories, datacenters, and other places with people moving, composed of a Processing Unit (10) that receives information both from a User Authentication Device (20) and an Image Capture Device (40). The Processing Unit (10) processes this information determining user category as well as user location, speed and direction of movement within a Gated Area (GA). In turn, the Processing Unit (10) triggers one or more Bars of Luminous Elements (31) arranged in Barriers (30) limiting a Gated Area (GA), giving every user (Authorized User [AU], Unauthorized User [UU] or Special User [SU]) a User Category Window (311, 312 or 313) that follows the movement of the user within the Gated Area (GA).

Abstract: Data processing circuitry comprises instruction queue circuitry to maintain one or more instruction queues to store fetched instructions; instruction decode circuitry to decode instructions dispatched from the one or more instruction queues, the instruction decode circuitry being configured to allocate one or more processor resources of a set of processor resources to a decoded instruction for use in execution of that decoded instruction; detection circuitry to detect, for an instruction to be dispatched from a given instruction queue, a prediction indicating whether sufficient processor resources are predicted to be available for allocation to that instruction by the instruction decode circuitry; and dispatch circuitry to dispatch an instruction from the given instruction queue to the instruction decode circuitry, the dispatch circuitry being responsive to the detection circuitry to allow deletion of the dispatched instruction from that instruction queue when the prediction indicates that sufficient processo