Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which maybe useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD)

Abstract: Indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: A biologics manufacturing process that connects the drug substance and drug product processes into an integrated, continuous process.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: A portable common geometry non-linear antenna apparatus including a partially transparent housing defining a cavity, and a generally hemispherical antenna disposed within the cavity. The generally hemispherical antenna further includes an electrically conductive ground portion, an electrically conductive signal portion, an electrically insulating portion disposed between the electrically conductive ground and signal portions, and an electrically conducting mesh portion connected in electric communication with the signal portion. A first contact operationally connected to the ground portion and a second contact operationally connected to the signal portion. The electrically conductive mesh portion typically extends or bulges away from the electrically insulating portion to define a Faraday cage.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: A portable common geometry non-linear antenna apparatus including a partially transparent housing defining a cavity, and a generally hemispherical antenna disposed within the cavity. The generally hemispherical antenna further includes an electrically conductive ground portion, an electrically conductive signal portion, an electrically insulating portion disposed between the electrically conductive ground and signal portions, and an electrically conducting mesh portion connected in electric communication with the signal portion. A first contact operationally connected to the ground portion and a second contact operationally connected to the signal portion. The electrically conductive mesh portion typically extends or bulges away from the electrically insulating portion to define a Faraday cage.

Abstract: A valve is provided and includes a bypass block defining a bypass flowpath fluidly communicable with main flowpaths, a member disposable within the bypass block to occupy and move between first and second positions, the member being configured to permit fluid flow through the bypass flowpath when occupying the first position and to block a portion of the bypass flowpath to thereby prevent fluid flow through the bypass flowpath when occupying the second position and an elastic element. The elastic element is coupled to the member and configured to bias the member in a biasing direction toward the second position responsive to a temperature of fluid flowing along the main flowpaths.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitizing or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorders which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: An apparatus for detecting a storm, including a partially transparent housing defining a cavity and a suspended magnetic element positioned within the cavity. The magnetic element is rotatable in a first plane and pivotable in second plane and third planes, wherein the second plane is perpendicular to the first plane and the third plane is perpendicular to the first plane and perpendicular to the second plane. A rapid pivot of the magnetic element away from the pull of gravity signals a close proximity of a storm. A first sensor operationally connected to the magnetic element for measuring the deflection of the magnetic element, dampening fluid substantially fills the cavity, a second sensor positioned within the housing for measuring the degree to which the magnetic element is level, and a laser operationally connected to the magnetic element and positioned to emit a beam of light corresponding to the orientation of the magnetic element.

Abstract: Memory controller circuitry may process the memory access requests by reordering the sequence of requests. Reordering the sequence of requests may decrease the power consumption of the memory controller and system memory associated with the memory controller. The memory controller may operate in at least an unconstrained power mode, a priority mode, and a constrained power mode. In the unconstrained power mode, the memory controller may process memory access requests at elevated and power consumption levels. In the priority mode, the memory controller may process memory access requests from select sources with reduced power consumption. In the constrained power mode, the memory controller may process all memory access requests at reduced power consumption levels. Capacitive-model based power monitoring circuitry may be used to monitor the interactions between the memory controller and the system memory to dynamically adjust the operating mode of the memory controller.

Abstract: Systems and methods for the use of headphones are provided. The systems and methods can offer ease of carrying, comfort, and/or use of headphones, particularly portable headphones that provide for a user adjustment of an audio equalizer setting directly at the headphones for a desired audio data frequency/amplitude profile. Moreover, a combination of the concepts of user-controlled sound dynamics are provided at the headphone device through computerized pendant that is configured to alter sound dynamics directly through it's own software application without needing to control the sound dynamics at the audio source. This allows a user of the headphones to switch between audio devices while maintaining a desired set of sound dynamics in the form of preset or custom audio profiles.

Abstract: Systems and methods for the use of headphones are provided. The systems and methods can offer ease of carrying, comfort, and/or use of headphones, particularly portable headphones that provide for a user adjustment of an audio equalizer setting directly at the headphones for a desired audio data frequency/amplitude profile. Moreover, a combination of the concepts of user-controlled sound dynamics are provided at the headphone device through computerized pendant that is configured to alter sound dynamics directly through it's own software application without needing to control the sound dynamics at the audio source. This allows a user of the headphones to switch between audio devices while maintaining a desired set of sound dynamics in the form of preset or custom audio profiles.

Abstract: A valve is provided and includes a bypass block defining a bypass flowpath fluidly communicable with main flowpaths, a member disposable within the bypass block to occupy and move between first and second positions, the member being configured to permit fluid flow through the bypass flowpath when occupying the first position and to block a portion of the bypass flowpath to thereby prevent fluid flow through the bypass flowpath when occupying the second position and an elastic element. The elastic element is coupled to the member and configured to bias the member in a biasing direction toward the second position responsive to a temperature of fluid flowing along the main flowpaths.

Abstract: A method for producing a tempered martensitic heat resistant steel for high temperature applications at an application temperature of up to 650° C. and to a steel produced by the method. The use of the steel in the production of components for high temperature applications such as turbine blades or casings, bolting and boiler tubes, heat exchangers or other elements in power generation systems.