Abstract: The disclosure provides TNF-like ligand 1a (TL1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to TL1a and inhibits interaction of TL1a and Death Receptor 3 (DR3) and which does not inhibit the interaction of TL1a and Decoy Receptor 3 (DcR3). The disclosure also provides uses of the TL1a-binding proteins.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitizing or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorders which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: A compound of Formula I: R1-L1-C(A)(A?)-CH2, -L2-R2 or a pharmaceutically acceptable salt thereof, for use in medicine, for example in the treatment of a disease or condition selected from the group comprising cancer, autistic spectrum disorders.

Abstract: Memory controller circuitry may process the memory access requests by reordering the sequence of requests. Reordering the sequence of requests may decrease the power consumption of the memory controller and system memory associated with the memory controller. The memory controller may operate in at least an unconstrained power mode, a priority mode, and a constrained power mode. In the unconstrained power mode, the memory controller may process memory access requests at elevated and power consumption levels. In the priority mode, the memory controller may process memory access requests from select sources with reduced power consumption. In the constrained power mode, the memory controller may process all memory access requests at reduced power consumption levels. Capacitive-model based power monitoring circuitry may be used to monitor the interactions between the memory controller and the system memory to dynamically adjust the operating mode of the memory controller.

Abstract: A method for producing a tempered martensitic heat resistant steel for high temperature applications at an application temperature of up to 650° C. and to a steel produced by the method. The use of the steel in the production of components for high temperature applications such as turbine blades or casings, bolting and boiler tubes, heat exchangers or other elements in power generation systems.

Abstract: An apparatus includes a memory circuit and an interface circuit. The interface circuit is coupled to the memory circuit. The interface circuit selects a phase value of clock signal adapted to clock the memory circuit.

Abstract: An apparatus includes a memory circuit and an interface circuit. The interface circuit is coupled to the memory circuit. The interface circuit selects a phase value of clock signal adapted to clock the memory circuit.

Abstract: Circuits, methods, and apparatus for transferring data from a device's input clock domain to a core clock domain. One example achieves this by using a retiming element between input and core circuits. The retiming element is calibrated by incrementally sweeping a delay and receiving data at each increment. Minimum and maximum delays where data is received without errors are averaged. This average can then be used to adjust the timing of a circuit element inserted in an input path between an input register clocked by an input strobe signal and an output register clocked by a core clock signal. In one example, an input signal may be delayed by an amount corresponding to the delay setting. In other examples, each input signal is registered using an intermediate register between the input register and the output register, where a clock signal is delayed by an amount corresponding to the delay setting.

Abstract: Circuits, methods, and apparatus that isolate an input register from spurious transitions on a DQS signal. One example receives an enable signal from a core. A logic circuit, which may be referred to as a one-half period circuit, shortens enable pulses at their front end by one-half a period. The shortened enable signal is passed to a storage element such as a register. Active pulses of the shortened enable signal clear the register, which provides a control signal closing a switch, such as an AND gate. The switch passes the DQS signal to the input register when closed and isolates the input register from the DQS signal when open. The shortened enable signal prevents the switch from opening early and passing spurious transitions on the DQS signal, for example during back-to-back non-consecutive read cycles.

Abstract: Circuits, methods, and apparatus that provide the calibration of input and output circuits for a high-speed memory interface. Timing errors caused by the fly-by routing of a clock signal provided by the memory interface are calibrated for both read and write paths. This includes adjusting read and write DQS signal timing for each DQ/DQS group, as well as inserting or bypassing registers when timing errors are more than one clock cycle. Timing skew caused by trace and driver mismatches between CK, DQ, and DQS signals are compensated for. One or more of these calibrations may be updated by a tracking routine during device operation.

Abstract: I/O blocks include input, output, and output enable circuits for interfacing with memory devices. The input circuit includes registers for capturing a double data rate signal, converting it into single data rate signals, and resynchronizing the single data rate signals. Multiple devices may be accessible with each device potentially having a different clock signal for resynchronizing. Another clock signal may be used to align/synchronize resulting signals from multiple devices. The resynchronized single rate signals can be converted into half-rate data signals, and the four half-rate data signals can be provided to resources in the programmable device core. The input circuit also may provide a half-rate clock signal synchronized with the half-rate data signals to the programmable device core. The half rate clock signal can be derived from the full-rate clock signal using a data strobe signal, a full-rate clock signal, or a half-rate clock signal as an input.

Abstract: Methods and circuitry for distributing and synchronizing a divided clock signal in an electronic device are disclosed. In one aspect of an embodiment, a series of registers distributes the divided clock signal and the series of registers is clocked by a full-speed clock signal from which the divided clock signal is derived. In another aspect, the divided clock signal and the full-speed clock signal are distributed to IO circuitry of the electronic device. In yet another aspect, the divided clock signal is also distributed to circuitry in a core of the electronic device.

Abstract: Circuits, methods, and apparatus that isolate an input register from spurious transitions on a DQS signal. One example receives an enable signal from a core. A logic circuit, which may be referred to as a one-half period circuit, shortens enable pulses at their front end by one-half a period. The shortened enable signal is passed to a storage element such as a register. Active pulses of the shortened enable signal clear the register, which provides a control signal closing a switch, such as an AND gate. The switch passes the DQS signal to the input register when closed and isolates the input register from the DQS signal when open. The shortened enable signal prevents the switch from opening early and passing spurious transitions on the DQS signal, for example during back-to-back non-consecutive read cycles.

Abstract: Read interface circuitry is disclosed that facilitates using a source-synchronous clock signal to calibrate the read interface. In one embodiment, configurable read interface circuitry allows a particular read path to be configured for use in calibrating a read interface of the destination device. In particular, a plurality of read paths are provided, each read path having a configurable multiplexor (“mux”) coupled to a capture register of the read path such that the mux can be configured to select either an input coupled to an inverted output of the capture register or an input coupled to a prior register in the read data path. When the inverted output of the capture register is selected, a source-synchronous clock signal (e.g., DQS or delayed DQS signal) provided at the capture register's clock input results in a toggle signal at the capture register's output. In one embodiment, that toggle signal is provided to a re-sync register clocked by a re-sync clock signal.

Abstract: Circuitry and methods are disclosed for capturing data from a double-data rate signal received from a source circuit, converting the double-data rate signal to single and/or half rate data signals, and re-synchronizing the data to the destination circuit's clock signal. In one embodiment, a first set of registers converts a double-data rate signal synchronized to a full-rate clock signal to two single-data rate signals. A second set of registers converts the single-data rate signals to four half-data rate signals. A third set of registers synchronizes the half-rate data signals to a half-rate clock signal.

Abstract: Methods and circuitry for distributing and synchronizing a divided clock signal in an electronic device are disclosed. In one aspect of an embodiment, a series of registers distributes the divided clock signal and the series of registers is clocked by a full-speed clock signal from which the divided clock signal is derived. In another aspect, the divided clock signal and the full-speed clock signal are distributed to IO circuitry of the electronic device. In yet another aspect, the divided clock signal is also distributed to circuitry in a core of the electronic device.

Abstract: Circuits, methods, and apparatus for transferring data from a device's input clock domain to a core clock domain. One example achieves this by using a retiming element between input and core circuits. The retiming element is calibrated by incrementally sweeping a delay and receiving data at each increment. Minimum and maximum delays where data is received without errors are averaged. This average can then be used to adjust the timing of a circuit element inserted in an input path between an input register clocked by an input strobe signal and an output register clocked by a core clock signal. In one example, an input signal may be delayed by an amount corresponding to the delay setting. In other examples, each input signal is registered using an intermediate register between the input register and the output register, where a clock signal is delayed by an amount corresponding to the delay setting.

Abstract: Circuits, methods, and apparatus for transferring data from a device's input clock domain to a core clock domain. One example achieves this by using a retiming element between input and core circuits. The retiming element is calibrated by incrementally sweeping a delay and receiving data at each increment. Minimum and maximum delays where data is received without errors are averaged. This average can then be used to adjust the timing of a circuit element inserted in an input path between an input register clocked by an input strobe signal and an output register clocked by a core clock signal. In one example, an input signal may be delayed by an amount corresponding to the delay setting. In other examples, each input signal is registered using an intermediate register between the input register and the output register, where a clock signal is delayed by an amount corresponding to the delay setting.