Abstract: The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

Abstract: The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

Abstract: The present invention relates to 2,6,7-substituted pyrrolo[2,3-d]pyrimidines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 2,6,7-substituted pyrrolo[2,3-d]pyrimidines and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

Abstract: The present invention relates to 2-(4-fluorophenyl)-3-(2-phenoxy-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo-[1,2-a]pyrazol-1-one, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, having the formula: and pharmaceutical compositions thereof, and methods for controlling the level of one or more inflammation inducing cytokines selected from the group consisting of, interleukin-1 (IL-1), Tumor Necrosis Factor-? (TNF-?), interleukin-6 (IL-6), and interleukin-8 (IL-8), thereby controlling, mediating, or abating disease states affected by the level of extracellular inflammatory cytokines in humans.

Abstract: The present invention relates to methods for treating diseases or disease states which are mediated or otherwise affected by the extracellular release of cytokines, said method comprising the step of administering to a human or higher mammal in need of treatment, one or more of the 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones of the present invention.

Abstract: The disclosure pertains to compositions and methods for modifying or refining the surface of a wafer suited for semiconductor fabrication. The compositions include working liquids useful in modifying a surface of a wafer suited for fabrication of a semiconductor device. In some embodiments, the working liquids are aqueous solutions of initial components substantially free of loose abrasive particles, the components including water, a surfactant, and a pH buffer exhibiting at least one pKa greater than 7. In certain embodiments, the pH buffer includes a basic pH adjusting agent and an acidic complexing agent, and the working liquid exhibits a pH from about 7 to about 12. In further embodiments, the disclosure provides a fixed abrasive article comprising a surfactant suitable for modifying the surface of a wafer, and a method of making the fixed abrasive article. Additional embodiments describe methods that may be used to modify a wafer surface.

Abstract: The present invention relates to 2,6,7-substituted pyrrolo[2,3-d]pyrimidines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 2,6,7-substituted pyrrolo[2,3-d]pyrimidines and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

Abstract: The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 2,8,9-substituted purines and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

Abstract: Control messages constructed in accordance with a first communications protocol for use in a communications network each include a first address identifier having a format defined by the first protocol. The control message is processed to derive a second address identifier having a format defined by a second communications protocol. The control message is re-formatted for transmission, in accordance with the second protocol, to a network system associated with the second address identifier.

Abstract: Compositions consisting essentially of the reaction product (including unreacted components) obtained by mixing (a) one or more selected fluorinated compounds and (b) one or more selected organic agents and providing in-situ generation of fluoride ions. Also, kits for forming such compositions and methods for using such compositions.

Abstract: Methods and apparatus for provisioning the use of multiple readers and/or wireless communication protocols within a defined area are provided. More specifically, a coordinator or the like can be used to manage the activation and deactivation of the multiple readers and/or communication protocols within a single reader such that interference between disparate technologies is avoided.

Abstract: An embroidered electrode (10) consists of embroidered elements (12, 13, 14) of electrically conductive thread sewn on a backing material (11). Within a given element the orientation of stitching is selected to be parallel to the direction in which the element extends.

Abstract: A turbine shroud assembly asymmetrical cooling element such as a shroud segment or a baffle includes an arcuate panel. The panel has a plurality of cooling apertures extending through the panel and an axially extending midline of the panel parallel to an axis of rotation of the arcuate panel. A symmetric portion of the cooling apertures have a symmetrical density of aperture inlets that is symmetric with respect to the axially extending midline. An asymmetric portion of the cooling apertures have an asymmetrical density of aperture inlets that is asymmetric with respect to the axially extending midline. One exemplary cooling element includes a high density area of the cooling apertures in the asymmetric portion having a higher density of aperture inlets than in the symmetric portion. A low density area of the cooling apertures in the asymmetric portion has a lower density of aperture inlets than in the symmetric portion of the cooling apertures.

Abstract: The present invention relates to cleaning processes for semiconductor substrates. More particularly, the present inventive method can provide enhanced particle removal efficiencies at a given material loss. In fact, in certain embodiments, the present method can achieve particle removal efficiencies of at least about 90%, while yet removing less than about 2 angstroms of any oxide present on the semiconductor substrate. As such, the present methods find particular applicability in the processing of advanced technology nodes.

Abstract: A method is provided for repairing a surface portion of an article including a metallic environmental resistant coating on a substrate. The coating includes a coating outer portion bonded with the substrate through a diffusion zone that includes at least one feature, for example Al and/or an intermetallic phase, in an amount detrimental to application of a metallic replacement coating and/or repair of the article. The method comprises removing the coating outer portion to expose a surface of the diffusion zone. The substrate and the diffusion zone are heated at a temperature and for a time sufficient to diffuse and/or dissolve at least a portion of the at least one feature in the exposed surface and in a portion of the diffusion zone beneath the exposed surface to a level below the detrimental amount. This provides a replacement surface portion integral with diffusion zone. Then a metallic replacement coating outer portion is applied to the replacement surface portion.

Abstract: The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein R comprises ethers or amines; R1 is: a) substituted or unsubstituted aryl; or b) substituted or unsubstituted heteroaryl; each R2 unit is independently selected from the group consisting of: a) hydrogen; b) —(CH2)jO(CH2)nR8; c) —(CH2)jNR9aR9b; d) —(CH2)jCO2R10; e) —(CH2)jOCO2R10 f) —(CH2)jCON(R10)2; g) —(CH2)jOCON(R10)2; h) two R2 units can be taken together to form a carbonyl unit; i) and mixtures thereof; R8, R9a, R9b, and R10 are each independently hydrogen, C1–C4 alkyl, and mixtures thereof; R9a and R9b can be taken together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; two R10 units can be take together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; j is an index from 0 to 5,

Abstract: The present invention relates to methods of processing wafer-like objects (e.g., having an exposed copper feature and/or including low-k dielectric material) with ozone. In certain preferred embodiments, a base is also used to process the wafer-like object(s).

Abstract: A turbine nozzle bifurcated impingement baffle includes axially forward and aft chambers with a gap therebetween, impingement holes through forward and aft baffle walls of the forward and aft chambers respectively, and a plenum chamber in fluid flow communication with the forward and aft chambers. An exemplary embodiment of the bifurcated impingement baffle further includes a single cooling air inlet to the plenum chamber enclosed within a plenum chamber enclosure the plenum chamber. A sealing plate is mounted between and sealed to the plenum chamber enclosure and the forward and aft chambers. The sealing plate has forward and aft inlet apertures disposed between the plenum chamber and the forward and aft chambers respectively. Forward and aft end plates cap radially inner ends of the forward and aft chambers. An outlet aperture in the forward end plate has an interstage seal cavity feed tube disposed therethrough.

Abstract: A gas turbine engine turbine blade includes a hollow airfoil extending radially from a blade root to a radially outer airfoil tip. The airfoil includes an airfoil outer wall having transversely spaced apart pressure and suction side walls meeting along chordally spaced apart leading and trailing edges of the airfoil. A radially extending cooling air supply channel within the airfoil includes a bank of pins integral with and extending transversely between the pressure and suction side walls. The bank of the pins is tuned such that a natural frequency of the blade associated with an engine forced driving mode of the blade is sufficiently away from a steady state engine operating frequency to substantially avoid natural frequency resonance of the blade during steady state engine operation. The bank of the pins is tuned by locations of the pins within the cooling air supply channel.

Abstract: A turbine nozzle segment includes a single hollow airfoil extending radially between radially outer and inner band segments. The airfoil has an airfoil wall with pressure and suction sides extending axially between leading and trailing edges of the airfoil. The airfoil wall surrounds a bifurcated cavity and a bifurcating rib extends through the bifurcated cavity and between the pressure and suction sides of the airfoil wall dividing the bifurcated cavity into forward and aft cavities. A stiffening rib extends radially outwardly from and along a radially outer surface of the outer band segment and axially and circumferentially from a pressure side forward corner of the outer band segment to the bifurcating rib. The outer and inner band segments, the bifurcating rib, and the stiffening rib are integral and made from a unitary one-piece casting.