Abstract: The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, or enantiomeric and diasteriomeric forms or pharmaceutically acceptable salts thereof, have the formula: 1

Abstract: A method for assembling a turbine nozzle for a gas turbine engine facilitates improving cooling efficiency of the turbine nozzle. The method includes providing a hollow doublet including a leading airfoil and a trailing airfoil coupled by at least one platform, wherein each airfoil includes a first sidewall and a second sidewall that extend between a respective leading and trailing edge. The method also includes inserting an insert into at least one of the airfoils, wherein the insert includes a first sidewall including a first plurality of cooling openings that extending therethrough, and a second sidewall including a second plurality of cooling openings extending therethrough, and wherein the first plurality of cooling openings facilitate more cooling of the airfoil than the second plurality of cooling openings.

Abstract: A method for assembling a turbine nozzle for a gas turbine engine facilitates improving cooling efficiency of the turbine nozzle. The method includes providing a hollow doublet including a leading airfoil and a trailing airfoil coupled by at least one platform, wherein each airfoil includes a first sidewall and a second sidewall that extend between a respective leading and trailing edge. The method also includes inserting an insert into at least one of the airfoils, wherein the insert includes a first sidewall including a first plurality of cooling openings that extending therethrough, and a second sidewall including a second plurality of cooling openings extending therethrough, and wherein the first plurality of cooling openings facilitate more airfoil vane sidewall cooling than the second plurality of cooling openings.

Abstract: A method is provided for repairing a surface portion of an article including a metallic environmental resistant coating on a substrate. The coating includes a coating outer portion bonded with the substrate through a diffusion zone that includes at least one feature, for example Al and/or an intermetallic phase, in an amount detrimental to application of a metallic replacement coating and/or repair of the article. The method comprises removing the coating outer portion to expose a surface of the diffusion zone. The substrate and the diffusion zone are heated at a temperature and for a time sufficient to diffuse and/or dissolve at least a portion of the at least one feature in the exposed surface and in a portion of the diffusion zone beneath the exposed surface to a level below the detrimental amount. This provides a replacement surface portion integral with diffusion zone. Then a metallic replacement coating outer portion is applied to the replacement surface portion.

Abstract: The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: 1

Abstract: A method for assembling a turbine nozzle for a gas turbine engine facilitates improving cooling efficiency of the turbine nozzle. The method includes providing a hollow doublet including a leading airfoil and a trailing airfoil coupled by at least one platform, wherein each airfoil includes a first sidewall and a second sidewall that extend between a respective leading and trailing edge. The method also includes inserting an insert into at least one of the airfoils, wherein the insert includes a first sidewall including a first plurality of cooling openings that extending therethrough, and a second sidewall including a second plurality of cooling openings extending therethrough, and wherein the first plurality of cooling openings facilitate more cooling of the airfoil than the second plurality of cooling openings.

Abstract: The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: 1

Abstract: The present invention relates to 4-aryl triazoles having the formula: 1

Abstract: Isoxazolone compounds having the generic structure: 1

Abstract: The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein R comprises ethers or amines; R1 is: a) substituted or unsubstituted aryl; or b) substituted or unsubstituted heteroaryl; two R2 units on the same carbon atom are taken together to form a spirocyclic ring having from 4 to 7 atoms, the balance of the R2 units are independently selected from the group consisting of: a) hydrogen; b) —O(CH2)jR8; c) —(CH2)jNR9aR9b; d) —(CH2)jCO2R10; e) —(CH2)jOCO2R10 f) —CH2)jCON(R10)2; and g) two R2 units can be taken together to form a carbonyl unit; R8, R9a, R9b, and R10 are each independently hydrogen, C1-C4 alkyl, and mixtures thereof; R9a and R9b can be taken together to form a carbocyclic or heterocyclic ring comprising from 3 to 7 atoms; two R10 uni

Abstract: A method for assembling a turbine nozzle for a gas turbine engine facilitates improving cooling efficiency of the turbine nozzle. The method includes providing a hollow doublet including a leading airfoil and a trailing airfoil coupled by at least one platform, wherein each airfoil includes a first sidewall and a second sidewall that extend between a respective leading and trailing edge. The method also includes inserting an insert into at least one of the airfoils, wherein the insert includes a first sidewall including a first plurality of cooling openings that extending therethrough, and a second sidewall including a second plurality of cooling openings extending therethrough, and wherein the first plurality of cooling openings facilitate more airfoil vane sidewall cooling than the second plurality of cooling openings.

Abstract: A gas turbine engine includes rotor blades including airfoils that facilitates reducing manufacturing losses due to airfoil trailing edge scarfing. Each airfoil includes a first and second sidewall connected at a leading edge and a trailing edge. The sidewalls define a cooling cavity that includes at least a leading edge chamber bounded by the sidewalls and the airfoil leading edge, and a trailing edge chamber bounded by sidewalls and the airfoil trailing edge. The cooling cavity trailing edge chamber includes a tip region, a throat, and a passageway region connected in flow communication such that the throat is between the tip region and the passageway region. Furthermore, the tip region is bounded by the airfoil tip and extends divergently from the throat, such that a width of the tip region is greater than a width of the throat.

Abstract: A method is provided for repairing a surface portion of an article including a metallic environmental resistant coating on a substrate. The coating includes a coating outer portion bonded with the substrate through a diffusion zone that includes at least one feature, for example Al and/or an intermetallic phase, in an amount detrimental to application of a metallic replacement coating and/or repair of the article. The method comprises removing the coating outer portion to expose a surface of the diffusion zone. The substrate and the diffusion zone are heated at a temperature and for a time sufficient to diffuse and/or dissolve at least a portion of the at least one feature in the exposed surface and in a portion of the diffusion zone beneath the exposed surface to a level below the detrimental amount. This provides a replacement surface portion integral with diffusion zone. Then a metallic replacement coating outer portion is applied to the replacement surface portion.

Abstract: The present invention relates to 4-aryl triazoles having the formula: 1

Abstract: A gas turbine engine includes rotor blades including airfoils that facilitates reducing manufacturing losses due to airfoil trailing edge scarfing. Each airfoil includes a first and second sidewall connected at a leading edge and a trailing edge. The sidewalls define a cooling cavity that includes at least a leading edge chamber bounded by the sidewalls and the airfoil leading edge, and a trailing edge chamber bounded by sidewalls and the airfoil trailing edge. The cooling cavity trailing edge chamber includes a tip region, a throat, and a passageway region connected in flow communication such that the throat is between the tip region and the passageway region. Furthermore, the tip region is bounded by the airfoil tip and extends divergently from the throat, such that a width of the tip region is greater than a width of the throat.

Abstract: In general, in one aspect, the disclosure describes a method of processing content for distribution over a computer network. The method includes receiving submitted electronic content, accessing identification of at least one of a set of more than one electronic book digital rights management (DRM) systems, and automatically generating an electronic book from the received electronic content for distribution in accordance with the identified electronic book digital rights management system(s).

Abstract: In general, in one aspect, the disclosure describes a method for use in electronic content distribution. The method includes storing sets of metadata corresponding to different electronic content titles available for distribution in accordance with different, respective, non-affiliated electronic book digital rights management schemes. At least some of the sets of metadata indicate at least one authorized retailer. The method also includes determining one or more sets of metadata for a retailer, the determined sets corresponding to electronic content the retailer is authorized to retail, and generating an output file of content available to the retailer that includes at least a portion of the determined sets of metadata.

Abstract: In general, in one aspect, the disclosure describes a method of processing content for distribution over a computer network. The method includes receiving submitted electronic content, accessing identification of at least one of a set of more than one electronic book digital rights management (DRM) systems, and automatically generating an electronic book from the received electronic content for distribution in accordance with the identified electronic book digital rights management system(s).

Abstract: A device for marking hidden delaminations in a structure subject to hidden delaminations comprising a wheeled spray paint can holder, wherein said holder is adapted to hold a paint can containing a nozzle which when depressed releases an upward spray of paint, and wherein said holder is fixedly connected to an outer tube containing therein an inner tube adapted for freely sliding inside said outer tube, wherein said inner tube contains a section extending beyond said outer tube in an upper axial direction, and wherein said inner tube is mounted on top of a spring in said outer tube, and wherein said inner tube contains a protrusion in said section, and wherein said inner tube contains one or more wheels, at or near the upper end of said section, for rolling said holder on an overhead surface, and wherein said outer tube contains means fixedly attached thereto for engaging said spring and located inside said outer tube and below said spring, and wherein when said outer tube is adapted through said means to con

Abstract: A device for detecting hidden delaminations in a structure subject to hidden delaminations comprising a rotary percussion tool head adapted at an end thereof to connect to an extension pole, wherein said head comprises at least one circular member, each circular member having on the periphery thereof projections extending in the radial direction and spaced apart in the circumferential direction, and a method of using same.