Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A computing node for a computing system includes a processor, conversion circuitry, and routing circuitry. The processor generates a data signal based on a function of an application executed by the computing system. The data signal has a first precision format and a first sparse representation. The conversion circuitry receives the data signal from the processor and generate a converted data signal by at least one of converting the first precision format to a second precision format and converting the first sparse representation to a second sparse representation. The routing circuitry transmits the converted data signal to switch circuitry of the computing system.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: Novel RET fusion molecules and uses are disclosed.

Abstract: An unmanned vehicle (20) for relaying radio frequency signals in a tactical communications network is described. The unmanned vehicle comprises a processor (22) arranged to receive the location of a first asset (40a); select a relay site (30) from at least one relay site; and control the unmanned vehicle to move to the selected relay site, wherein at the selected relay site, communication between the first asset and the unmanned vehicle is enabled. The unmanned vehicle also comprises a receiver for receiving data from the first asset; and a transmitter for transmitting the data to a second asset (40b, 20, 10). A control unit (60) for an unmanned vehicle, a tactical communications network comprising a plurality of unmanned vehicles, and a method of relaying signals in a tactical communications network using an unmanned vehicle are all also described.

Abstract: There is described a method of producing a flexible structure and sensor devices incorporating the former, such as wireless LC sensors, that comprises a plurality of thin-film layers of elastomeric material and at least one layer of micro-wrinkled electrically conductive material. The method includes steps leading to 2D wrinkled metallised polydimethylsiloxane (PDMS) layers enabling considerable flexibility with negligible bending failure for angles up to 180 degrees.

Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. a process for preparing a compound of formula (I) wherein, R1, R2 and X1 are as defined in the description, and which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Abstract: An electric vehicle includes a system for charging a battery of the electric vehicle. The system includes a sensor for obtaining a reference measurement of the battery during charging and a processor. The processor is configured to calculate an augmented state from the reference measurement, determine an anode voltage from the augmented state, compare the anode voltage to a threshold, and adjust a charging rate based on the comparison of the anode voltage to the threshold.

Abstract: Microelectromechanical systems (MEMS) switches are disclosed. The MEMS switch may have an actuation voltage greater than the expected voltage of a signal being passed by the MEMS switch in normal operation. The MEMS switches may include a distributed hinge structure in some embodiments. Radial contact pads are included in some embodiments, with or separate from the distributed hinge.

Abstract: A computing node for a computing system includes a processor, conversion circuitry, and routing circuitry. The processor generates a data signal based on a function of an application executed by the computing system. The data signal has a first precision format and a first sparse representation. The conversion circuitry receives the data signal from the processor and generate a converted data signal by at least one of converting the first precision format to a second precision format and converting the first sparse representation to a second sparse representation. The routing circuitry transmits the converted data signal to switch circuitry of the computing system.

Abstract: The invention provides antibodies to tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: A system and method are provided for operating a wind farm includes determining a wind direction and identifying a turbine cluster, which is a subset of a plurality of wind turbines of the wind farm. The subset includes an upwind turbine and a downwind turbine that is affected by a wake emanating from the upwind turbine. The controller then determines a difference between a freestream maximal cluster power output and a wake-affected cluster power output for the turbine cluster. The controller determines a mitigation setpoint combination for the subset configured to establish a mitigated cluster power output. Based on the mitigation setpoint combination, an operating state of at least one wind turbine of the turbine cluster is changed.

Abstract: Methods and compositions for treating cancer such as melanomas are disclosed.

Abstract: A polymer composition comprising at least one EPDM polymer, wherein the at least one EPDM has an ENB content per polymer chain (EPC) of from 80 to 150 determined according to equation (I): EPC = ( [ ENB ] × 10 × Polymer ? Mn ) / 120 ? g / mol ( I ) wherein ‘[ENB]’ is the content of units derived from ENB in the EPDM polymer in % by weight (based on the total weight of the polymer which is 100% by weight) and Polymer Mn is the number average molecular weight in kg/mol of the EPDM polymer as determined by gel permeation chromatography a content of ENB from 6 to 20% by weight. Also provided is a polymer blend composition comprising a blend of a first EPDM polymer and a second EPDM polymer wherein the polymer blend has an ENB content per polymer chain (EPC) of from 80 to 150 and wherein the polymer blend has a total ENB content of from 7.5 to 20% by weight based on the total weight of the polymer blend.

Abstract: Systems and methods facilitate sensing and tallying defecation events of subjects, such as participants in clinical trials for treatments for treating digestive diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and chronic constipation. Systems and methods may also be used by individual patients for sensing and tallying defecation events, and resulting data may be reviewed by a healthcare provider when evaluating patient gastrointestinal health and/or treatments.

Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: A stand-alone modular removable rudder system for watercraft having a rudder comprising a steering handle coupled to a quick release mechanism adapted to releasably secure said steering handle to said watercraft in proximity to the operator, said system further comprising, a rudder mount adapted to be coupled to the rear of the watercraft by a quick release mechanism adapted to releasably secure said rudder mount to said watercraft, said rudder being carried by a rudder support pivotal about said rudder mount and cables operatively connecting said steering handle to said rudder mount whereby the steering handle can be operated to steer the rudder.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: The present invention relates to compounds of Formulae (IA), (IB), (IIA), and (IIB) or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, optical isomer, N-oxide, and/or prodrug thereof. The invention also relates to the processes for the preparation of those compounds, pharmaceutical compositions comprising those compounds, and the uses of those compounds in treating diseases or conditions associated with inflammatory bowel disease, in particular ulcerative colitis and Crohn's disease.