Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.

Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.

Abstract: Impedance paths for integrated circuits having microelectromechanical systems (MEMS) switches that allow for electrical charge to bleed from circuit nodes to fixed electric potentials (e.g., ground) are described. Such paths are referred to herein as charge bleed circuits. The circuit nodes may be circuit locations where electrical charge may accumulate because there is no other path for the electrical charge to dissipate. In some embodiments, a charge bleed circuit includes a switchable device (e.g., a MEMS switch, a solid-state device switch, or a circuit including various solid-state device switches that, collectively, implement a device that can be switched on and off) that connects and disconnects the impedance path from a circuit node. This may allow the device to perform different types of measurements at desired performance levels.

Abstract: Microelectromechanical systems (MEMS) switches are disclosed. Parallel configurations of back-to-back MEMS switches are disclosed in some embodiments. An isolation connection of constant electrical potential may be made to a midpoint of the back-to-back switches. In some embodiments, a separate MEMS switch is provided as a shunt switch for the main MEMS switch. MEMS switch device configurations having multiple switchable signal paths each coupling a common input electrode to a respective output electrode are also disclosed. The MEMS switch device includes shunt switches each coupling a respective output electrode to a reference potential. The presence of a shunt switch coupled to an output electrode enhances the isolation of the signal path corresponding to that output electrode when the path is open.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: An adder for fractional logarithmic number system (FLNS) format operands includes a compare-and-swap circuit that inputs first and second FLNS operands represented by fixed point values and provides a greater one as operand x and a lesser or equal one as operand y. Sign bits are sx and sy of x and y, respectively, qx and qy, are integer portions of x and y, respectively, fraction portions of x and y have integer values rx and ry, respectively. The compare-and-swap circuit is configured to provide sx as a sign bit, sz of a sum z=x(1+y/x) for x?0. A subtraction circuit subtracts (qy+ry/n)?(qx+rx/n) and outputs q? and r?, such that ?=y/x, where n=2wr and wr is a bit-width of rx and ry. An approximation circuit provides an approximation of (1+?) to a nearest FLNS value, ?, as fixed point value having an integer portion q? and a fraction portion that has an integer value r?.

Abstract: A method for changing an activation state of an interruption module for selectively interrupting at least one passive cathodic protection unit from a metallic structure. The method includes enabling a global positioning system (GPS) receiver in data communication with a controller of the interruption module, receiving GPS time via the GPS receiver from at least one global positioning system satellite in data communication therewith, synchronizing a real-time clock time of a real-time clock in data communication with the controller to GPS time, disabling the GPS receiver and changing the activation state of the interruption module if a predetermined activation state change time of the interruption module is between the local real-time clock time and the GPS time.

Abstract: The invention provides methods of treating taupathies such as Alzheimer's disease with antibodies that bind to human tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: A watercraft mounting system that embodies a moving mounting platform and a protective hull cavity which provides protection, prevents damage and improves storage of data collection systems.

Abstract: A bone cement pressuriser (50) comprising a pressuriser head. The pressuriser head has a first side (51) coupled to or configured to couple to an end of a pressuriser handle and a second side (52) configured to transfer pressure to bone cement in a bone cavity. The second side of the pressuriser head is defined by a first, convex curved surface (53) and a second surface (54) forming a ring surrounding the first surface and extending radially beyond the first surface. A method of pressurising bone cement using the bone cement pressuriser is also disclosed. The first surface is configured to pressurise bone cement within a bone cavity and the second surface is configured to both pressurise bone cement within the bone cavity and to seal about the periphery of the bone cavity.

Abstract: A dishwasher for treating dishes according to an automatic cycle of operation includes a tub at least partially defining a treating chamber with an access opening. A door selectively closes the access opening. At least one dish rack is located within the treating chamber. A rotating arm assembly is located within the tub below the at least one dish rack and has a rotatable hub with a liquid conduit. A spray arm is carried by the hub and fluidly coupled to the liquid conduit. An air mixing arm is carried by the hub.

Abstract: A beverage brewing system which includes a container and a beverage brewing apparatus. The container may include a body portion defining a cavity containing a beverage ingredient. The body portion may be flexible so that when it is unimpeded during a beverage vend is can expand from an initial volume to a maximum volume. The beverage brewing apparatus may support the container and may include an expansion limiter that can limit the expansion of the container during the beverage vend. The beverage brewing apparatus may operate in a first mode whereby the expansion limiter does not impede the container and the container expands from the initial state to the maximum expanded state during the beverage vend. The beverage brewing apparatus may operate in a second mode whereby the expansion limiter impedes the container and prevents the container from expanding to the maximum expanded state during the beverage vend.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.

Abstract: The invention provides antibodies to tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: Methods of treating a head and neck cancer are disclosed.

Abstract: Devices, kits and methods described herein may include a dressing that is pre-strained and stored for a period of time after which the dressing is applied to the skin of a subject.

Abstract: A cathodic protection (CP) interruption system includes a metallic structure and a plurality of passive CP units embedded in an electrolytic medium, a plurality of test units electrically coupled with the structure and each of the CP units, and a low-power consumption component arrangement. The arrangement includes a real-time clock (RTC) and a GPS receiver coupled with each test unit for receiving GPS time from a GPS satellite. A controller is communicatively coupled with each RTC and GPS receiver for activating the GPS receiver once the RTC reaches a predetermined time to synchronize a RTC time of each RTC with GPS time. Interruption modules are coupled in electrical and data communication with the controller. The controller selectively changes an activation state of each interruption module once the RTC time reaches a predetermined activation state change time to selectively electrically couple or decouple each CP unit from the structure.

Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.