Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: Methods and compositions for treating cancer such as melanomas are disclosed.

Abstract: A polymer composition comprising at least one EPDM polymer, wherein the at least one EPDM has an ENB content per polymer chain (EPC) of from 80 to 150 determined according to equation (I): EPC = ( [ ENB ] × 10 × Polymer ? Mn ) / 120 ? g / mol ( I ) wherein ‘[ENB]’ is the content of units derived from ENB in the EPDM polymer in % by weight (based on the total weight of the polymer which is 100% by weight) and Polymer Mn is the number average molecular weight in kg/mol of the EPDM polymer as determined by gel permeation chromatography a content of ENB from 6 to 20% by weight. Also provided is a polymer blend composition comprising a blend of a first EPDM polymer and a second EPDM polymer wherein the polymer blend has an ENB content per polymer chain (EPC) of from 80 to 150 and wherein the polymer blend has a total ENB content of from 7.5 to 20% by weight based on the total weight of the polymer blend.

Abstract: Systems and methods facilitate sensing and tallying defecation events of subjects, such as participants in clinical trials for treatments for treating digestive diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and chronic constipation. Systems and methods may also be used by individual patients for sensing and tallying defecation events, and resulting data may be reviewed by a healthcare provider when evaluating patient gastrointestinal health and/or treatments.

Abstract: A stand-alone modular removable rudder system for watercraft having a rudder comprising a steering handle coupled to a quick release mechanism adapted to releasably secure said steering handle to said watercraft in proximity to the operator, said system further comprising, a rudder mount adapted to be coupled to the rear of the watercraft by a quick release mechanism adapted to releasably secure said rudder mount to said watercraft, said rudder being carried by a rudder support pivotal about said rudder mount and cables operatively connecting said steering handle to said rudder mount whereby the steering handle can be operated to steer the rudder.

Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: The present invention relates to compounds of Formulae (IA), (IB), (IIA), and (IIB) or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, optical isomer, N-oxide, and/or prodrug thereof. The invention also relates to the processes for the preparation of those compounds, pharmaceutical compositions comprising those compounds, and the uses of those compounds in treating diseases or conditions associated with inflammatory bowel disease, in particular ulcerative colitis and Crohn's disease.

Abstract: Some embodiments of the present disclosure relate to systems and methods including generating, by infrared spectroscopy, spectra data identifying quantities and associated wavelengths of radiation absorption for each of a plurality of wine samples as determined by the infrared spectroscopy; converting the spectra data for each wine sample to a set of discretized data; transforming the discretized data into a visual image representation of each respective wine sample, the visual image representation of each wine sample being an optically recognizable representation of the corresponding converted set of discretized data; and storing a record including the visual image representation of each wine sample in a memory.

Abstract: Some embodiments of the present disclosure relate to systems and methods including acquiring an image including an indication of at least one wine; identifying, by optical character recognition, the at least one wine in the acquired image; correlating each of the identified at least one wines to a visual image representation of each wine; and executing a trained computer vision classification system using the visual image representation of each of the identified wines and labeled visual image representations of at least one wine associated with a user flavor profile including at least one classification as inputs to generate an output including, for each of the identified wines, an indication of whether the identified wine corresponds to the at least one classification associated with the user flavor profile.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: The electrochemical sensor system includes a capillary and a conductive wire at least partially disposed within the capillary. The wire is provided as a plurality of wires, such as a pair wires. The plurality of wires is disposed substantially parallel within the capillary. The wire extends from a first terminal end of the capillary to a second terminal end of the capillary. Where the wire is provided as a plurality of wires, the capillary includes a capillary wall separating the plurality of wires. The first terminal end of the capillary includes an electrode surface where the wire is disposed therethrough and is exposed, thus forming an electrode. The exposed wire is configured to form a liquid-air interface where a droplet is disposed on the exposed wire. The wire extending from the second terminal end of the capillary is coupled to a processor configured to perform the electrochemical analysis.

Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.

Abstract: Present invention relates to pneumatic connector assembly for pneumatically coupling a pressure source and an inflatable mattress or controlling the inflation and/or deflation of said inflatable mattress.

Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.

Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.

Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.

Abstract: Embodiments of the present invention relate to a platform for controlling production and distribution of consumable items based on machine learning processes derived from chemical profiles of the consumable items.