Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: A modular conveying assembly includes active roller control for reducing backline pressure without product to product contact when accumulating products. Methods are discussed for manipulating objects by a bump-through indexing operation, a slug-control indexing operation, a catch-and-release indexing operation, box or case turning operations, and zero-pressure accumulation operations.

Abstract: A system for data rights management and data distribution using deliberately constrained message integrity. When linked with a public distributed ledger technology (DLT) (e.g., a blockchain, a directed acyclic graph (DAG)), a system in accordance with this disclosure discourages redistribution of raw data in a decentralized manner without the need for policing or identification-based reputation building making it suitable for anonymous or single use data purchases.

Abstract: Disclosed is a dispensing head that includes a first spindle configured for movement in a vertical direction, a first nozzle operatively attached to the spindle, a heater device removably attachable to the dispensing head. The heater device includes a heat source and an opening configured to receive the first nozzle. The heat source is configured to heat the first nozzle above an ambient temperature. An assembly system is further disclosed, along with a method of heating a nozzle.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non-small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation.

Abstract: Systems, devices, and methods for electrical connection between components of wearable heads-up displays are described. A wearable heads-up display can include a first arm and a second arm, bridged by a front frame. The first arm can carry electrical components, the second arm can carry a power source, and the front frame can carry a set of electrically conductive current paths which provide electrical coupling between the power source and the electrical components. The first arm and the second arm can each rotate about a respective hinge relative to the front frame. A flexible, dynamic set of electrically conductive current paths can couple the electrical components in the first arm to the set of electrically conductive current paths in the front frame, and another flexible, dynamic set of electrically conductive current paths can couple the power source in the second arm to the connector in the front frame.

Abstract: A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.

Abstract: The portable cryosurgical device is economical, easy to use and operate, and delivers cryogenic material such as nitrous oxide and carbon dioxide gas in any direction or orientation. The delivered materials destroy target tissue using extremely cold temperatures and the abrasives formed when the cryogenic material becomes a solid. The device includes a portable countertop enclosure housing a cryogen source, a cryogen flow tube in fluid communication with the ciyogen source, and a flow path assembly. The flow path assembly includes a valve between the ciyogen source and the cryogen flow tube having substantially zero dead volume. The flow path assembly can include a quick-connect cryogen tank adapter and an in-line ciyogen filter. The flow path assembly delivers liquefied compressed gas from the cryogen source to a terminal end of the cryogen flow tube without a phase change occurring in the flow path.

Abstract: A method for use in managing a networked computing system includes: receiving a trigger for a migration of a plurality of local migration artifacts from a first deployment state associated with an on-premises network management system to a second deployment state; and migrating the plurality of local migration artifacts from the first deployment state associated with the on-premises network management system to the second deployment state associated with the cloud-based provisioning system. The migration is seamless and includes reconciling at least one local migration artifact of the plurality of local migration artifacts with a plurality of remote migration artifacts maintained by the cloud-based provisioning system.

Abstract: A modular conveying assembly including a plurality of modules joined together, each module including a bushing housing, a coupling housed in the bushing housing, an axle coupled to the coupling and supported for rotation relative to the module, a drive pin coupled to the coupling, and a driven surface fixed to the drive pin. The modular conveying assembly also including a driving member that is in selective engagement with the driven surface to affect rotation of the axle.

Abstract: A focused treatment tip (FTT) for controlling the evaporation rate and providing targeted delivery of low temperature liquified gases for contact with living tissue includes a contoured body. When filled with liquified gas, the device insulates the gas from waste heat sources, such as the surrounding environment. The device can control the evaporation rate of the liquified gas at the treatment site. The controlled evaporation rate affects the rate of heat transfer from the treated tissue allowing for controlled exposure times and desired outcomes. The device can be used with various application tips to further define the target tissue area to be treated while minimizing collateral damage to surrounding tissue and isolating the gas within the contoured body and focusing heat transfer to the desired treatment area. The device may use transparent materials that make the treatment visible to the operator while the liquified gas is evaporating.

Abstract: This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non-small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation.

Abstract: An off-board battery charger for a vehicle may include a high-voltage connector having first, second and power supply connector ports. The first connector port connects to a vehicle controller via a first cable. The second connector port connects to a vehicle battery via a second cable. And, the power supply connector port is electrically connected with the second port and receives power via a power supply cable from a separate and external power supply.

Abstract: A pressure regulating system for use with a mechanical seal and stationary equipment for applying a substantially uniform force or load to a stacked set of packing elements. The force applied to the packing elements can be regulated or controlled in real time and in a remote manner. The mechanical seal includes an axially movable follower element that can be energized by pressurized fluid to move between a pre-loaded position where the follower element does not apply an axial load to the packing elements to a loaded position where the follower element applies the axial load to the packing elements.

Abstract: A micro-inverter assembly for use in a photovoltaic system includes a housing, a direct current (DC)-to-alternating current (AC) micro-inverter disposed within the housing, and a DC connector electrically coupled to the DC-to-AC micro-inverter. The DC connector is positioned within a recess formed in a bottom surface of the housing such that at least one electrical contact of the DC connector is accessible from outside the housing. According to alternative embodiments, the DC connector comprises a plug-and-play connector constructed for one of a rotational engagement and a translational engagement with a DC connector of a photovoltaic (PV) panel.

Abstract: Systems and methods are provided for new network device provisioning without Internet access. One method may include a method of network device provisioning without Internet access, the method including entering a pre-shared key (PSK) in a dynamic host configuration protocol (DHCP) message, obtaining the PSK from a set of DHCP message options by an onboarding network device requesting to join a private network, presenting the PSK, by the onboarding network device, to a network management system (NMS) of the private network, validating the PSK by the NMS, and updating an inventory list of the NMS to include the onboarding network device in the inventory list.

Abstract: A modular conveying assembly including a plurality of modules joined together, each module including a bushing housing, a coupling housed in the bushing housing, an axle coupled to the coupling and supported for rotation relative to the module, a drive pin coupled to the coupling, and a driven surface fixed to the drive pin. The modular conveying assembly also including a driving member that is in selective engagement with the driven surface to affect rotation of the axle.