Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: The present application pertains to a braided dual-sided compression packing seal, methods for producing and using such a seal, and apparatuses suitable for producing such a seal. The braided dual-sided compression packing seal is made up of two or more different materials that are braided together in such a way that, in cross-section, the compression packing seal has an asymmetrical configuration relative to a first axis that is substantially perpendicular to the longitudinal axis and is substantially perpendicular to a side of the compression packing seal. Accordingly, when viewed in a cross-sectional plane, the compression packing seal may expose substantially only a first material along a first side of the seal, and substantially only a second material along a second side of the seal.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: A busbar assembly includes a mesh busbar configured to electrically couple a first component to a second component. An electrical coupling method including securing a mesh busbar to a first component and a second component to electrical couple the first component to the second component.

Abstract: A flow modulation device 300 for controlling a rheological state of a dispensed pressurized fluid includes a porous element 304 and an exit tube. The porous element 304 is in fluid communication with a distal end of an outlet tube 303 and receives pressurized fluid in a first rheological state. The porous element 304 includes a plurality of channels that divide a flow channel into a plurality of flow paths through which the pressurized fluid flows and that modulates the flow of the pressurized fluid. The exit tube 305 includes proximal end 355 and distal end 345 and an intermediate body including a sidewall 365 defining a hollow internal lumen 375. The exit tube 305 is in fluid communication with the porous element 304 and receives the modulated pressurized fluid from the plurality of flow paths and refocuses the fluid to dispense the pressurized fluid in a second rheological state.

Abstract: Methods and devices are provided for generating, delegating, and/or authenticating hierarchical globally unique identifier (HGUID) certificates that are arranged in domain-name form to permit delegation and authentication as a Fully Qualified Domain Name (FQDN). A first hierarchical device certificate is obtained that includes at least part of a first unique device identifier for a first device and a base domain name, wherein the first hierarchical device certificate includes a fully qualified domain name and the first unique device identifier includes at least one of a type/model identifier or an origin/manufacturer of the first device. The first hierarchical device certificate is sent to an authenticating device to prove the first device has authority to perform a transaction within a restricted domain as defined by the first hierarchical device certificate. An indication may then be received from the authenticating device that the first device has been authenticated to perform the transaction.

Abstract: A detection apparatus and method arranged to detect defects within a flexible pipe at least partially surrounded by seawater. The detection apparatus comprises a seawater electrode, an impedance monitor and a processor. The seawater electrode is arranged to be in contact with seawater surrounding at least part of a flexible pipe. The impedance monitor is arranged to measure the impedance between a metallic structural component of the flexible pipe extending at least partially along the length of the flexible pipe and the seawater electrode in response to an electrical test signal applied to the seawater electrode. The processor is arranged to determine the distance from the seawater electrode to a pipe defect electrically connecting the metallic structural component to seawater using the measured impedance.

Abstract: A vehicle includes an electric machine, a battery, an inverter, and a flexible circuit. The electric machine is configured to propel the vehicle. The inverter is configured to convert direct current from the battery into alternating current. The flexible circuit has a sensor embedded therein that is configured to measure a first phase of the alternating current. The sensor is secured to an output terminal of the inverter that is connected to a first winding phase of the electric machine.

Abstract: A modular conveying assembly including a plurality of modules joined together, each module including a bushing housing, a coupling housed in the bushing housing, an axle coupled to the coupling and supported for rotation relative to the module, a drive pin coupled to the coupling, and a driven surface fixed to the drive pin. The modular conveying assembly also including a driving member that is in selective engagement with the driven surface to affect rotation of the axle.

Abstract: A structural assembly (900) and method of fabricating the same, the method comprising: providing a first member (204) comprising a bond surface (800) and a plurality of protrusions (802) extending from the bond surface (800), a length of each of the protrusions (802) from the bond surface (800) being less than or equal to 2 mm; providing a second member (202) comprising a fibre-reinforced composite material, the fibre-reinforced composite material comprising a plurality of elongate fibres (902) embedded in a polymer matrix (904); while the polymer matrix (904) is in its plastic state, forcing the second member (202) against the bond surface (800) and the protrusions (802) so as to cause the second member (202) to form onto the bond surface (800) and the protrusions (802); and thereafter causing the polymer matrix (904) to harden, thereby fixing the first member (204) to the bond surface of the second member (202).

Abstract: A portable charger system provides two charger ports with different charging characteristics. Two devices having different charging characteristics may be coupled to the two charger ports to be charged simultaneously.

Abstract: A headgear for use with a patient interface for delivering a flow of breathable gas to a patient includes at least a strap adapted to position the patient interface in sealing engagement with the patient's airways. The strap is constructed from an elastomer and a first side of the strap includes a first region on a portion of its surface that is textured to reduce friction with objects contacting the strap. A textured surface coating for a portion of an elastomer strap included in a headgear system is adapted to contact the skin of a patient, when in use, and the coating has a Ra value greater than zero. A vent for use with a patient interface for delivering a flow of breathable gas to a patient includes a plurality of rises and runs in a stepped arrangement; and a plurality of holes in the stepped arrangement for the venting of gas.

Abstract: A durable system for controlling variable valve actuation of an engine valve corresponding to a cylinder of an automobile engine. The system includes first and second crowned cams having first and second lift profiles and a rocker arm assembly. The rocker assembly includes a first arm having an end connected to said engine valve, having a high impact roller following the first crowned cam operating the engine valves according to a first lift profile. The rocker arm assembly also includes a second arm having durable slider pads riding on the second crowned cam to operate said engine valve according to a second lift profile. A latch secures the second arm relative to the first arm when in a latched position causing the valve to operate according to a second lift profile. The valve operates according to a first lift profile when the latch is not in the latched position.

Abstract: A magnet for transporting a particle beam in a target magnet field may include a first set of coils and a second set of coils. According to some aspects, the first and second set of coils may be configured to generate a combined desired magnetic field within the bore and may be configured to generate a combined magnetic field weaker than the desired magnetic field outside the bore.

Abstract: Embodiments of the invention provide systems and methods for monitoring and removing contaminants from a conveyor surface based upon predicted frictional engagement qualities detected on a conveyor surface. In some examples, the methods may include monitoring the conveyor surface with at least one sensor configured to sense a condition on the conveyor surface. The sensor may detect the presence of a contaminant, and communicate the location of the detected contaminant to a processor. A treatment cycle may then be initiated to remove or displace the contaminant from the conveyor surface after the presence of a contaminant has been detected.

Abstract: A modular conveying assembly includes active roller control for reducing backline pressure without product to product contact when accumulating products. Methods are discussed for manipulating objects by a bump-through indexing operation, a slug-control indexing operation, a catch-and-release indexing operation, box or case turning operations, and zero-pressure accumulation operations.

Abstract: Apparatus for providing optical radiation (1), which apparatus comprises a laser diode (2), a pulse generator (9), and a modulator (5), wherein: the pulse generator (9) is configured to emit picosecond pulses; the modulator (5) is configured to emit nanosecond pulses; the laser diode (2) has a first terminal (6) and a second terminal (7); the pulse generator (9) is connected to the first terminal (6); and the modulator (5) is configured to bias the laser diode (2) below a lasing threshold (8) of the laser diode (2), and the apparatus being characterized in that: the modulator (5) is connected to the second terminal (7); the pulse generator (9) comprises a semiconductor junction (32) connected to a differentiator (4); the semiconductor junction (32) is such that electric current flowing through the semiconductor junction (32) can be turned off more quickly than it can be turned on; and the differentiator (4) is such that a step change that occurs when the electric current flowing through the semiconductor junc

Abstract: A vehicle charging includes a housing, a sensor system configured to detect if a vehicle is parked near the housing, and a notification system configured to communicate an alert if the vehicle is parked near the housing and charging has not been initiated within a threshold amount of time. The alert indicates improper usage of the vehicle charging station to an operator of the vehicle.

Abstract: A headgear for use with a patient interface for delivering a flow of breathable gas to a patient includes at least a strap adapted to position the patient interface in sealing engagement with the patient's airways. The strap is constructed from an elastomer and a first side of the strap includes a first region on a portion of its surface that is textured to reduce friction with objects contacting the strap. A textured surface coating for a portion of an elastomer strap included in a headgear system is adapted to contact the skin of a patient, when in use, and the coating has a Ra value greater than zero. A vent for use with a patient interface for delivering a flow of breathable gas to a patient includes a plurality of rises and runs in a stepped arrangement; and a plurality of holes in the stepped arrangement for the venting of gas.

Abstract: A method and apparatus are disclosed for determining a bending radius of a flexible pipe. The apparatus includes at least one bend sensor element comprising an elongate flexible substrate and at least one bend sensitive element on the substrate that has at least one electrical characteristic that is responsive to angular displacement of the substrate. The apparatus also comprises a flexible crush resistant elongate housing that supports and surrounds the bend sensor element.