Abstract: A focused treatment tip (FTT) for controlling the evaporation rate and providing targeted delivery of low temperature liquified gases for contact with living tissue includes a contoured body. When filled with liquified gas, the device insulates the gas from waste heat sources, such as the surrounding environment. The device can control the evaporation rate of the liquified gas at the treatment site. The controlled evaporation rate affects the rate of heat transfer from the treated tissue allowing for controlled exposure times and desired outcomes. The device can be used with various application tips to further define the target tissue area to be treated while minimizing collateral damage to surrounding tissue and isolating the gas within the contoured body and focusing heat transfer to the desired treatment area. The device may use transparent materials that make the treatment visible to the operator while the liquified gas is evaporating.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: Methods and systems for designing and manufacturing RF devices is provided. The disclosed methods allow for quick and efficient printing without having to generate a CAD file or the like to generate the build file. This can be achieved by receiving RF inputs, such as inputs generated from an RF simulation, and combining that with geometry design data, such as boundary geometry information that can include an outer geometry and size of the device to be printed. Further, the RF devices that are produced can use triply periodic minimal surface constructs as the base element of the device.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

Abstract: Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: A method and apparatus for detecting pipe entrenchment or upheaval of a flexible pipe and/or the presence of an external feature to the flexible pipe. The method includes helically winding a temperature sensing element around a layer of a flexible pipe, helically winding a heating element around a layer of a flexible pipe, heating the heating element to a pre-determined temperature, measuring the temperature at at least two locations along the flexible pipe, comparing the measured temperature response at the at least two locations, and making a determination, from the comparison of measured responses, regarding the exterior vicinity of the pipe at one of the at least two locations.

Abstract: The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4x, R4y, m, n and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controlling weeds, in particular in crops of useful plants.

Abstract: The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4 and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controlling weeds, in particular in crops of useful plants.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A method for use in managing a networked computing system includes: receiving a trigger for a migration of a plurality of local migration artifacts from a first deployment state associated with an on-premises network management system to a second deployment state; and migrating the plurality of local migration artifacts from the first deployment state associated with the on-premises network management system to the second deployment state associated with the cloud-based provisioning system. The migration is seamless and includes reconciling at least one local migration artifact of the plurality of local migration artifacts with a plurality of remote migration artifacts maintained by the cloud-based provisioning system.

Abstract: The present disclosure relates to methods of treating, preventing, or modulating diabetes in a patient in need thereof using a device for transplanting cells into a host body, specifically a method of treating diabetes in a patient in need thereof, comprising: implanting a device in the patient, wherein the device comprises: a porous scaffold comprising an immunologically compatible polymer mesh forming the walls of at least one chamber, an opening at either or both of a proximal end and a distal end of the chamber, at least one removable, non-porous plug configured to be positioned within the lumen of the at least one chamber, maintaining the device in the patient's body until the device is infiltrated with vascular and connective tissues; and infusing the chamber with cells, wherein at least some of the cells express insulin

Abstract: A modular power converter system includes a plurality of active power link modules (APLMs) coupled to each other, each APLM having a plurality of switching devices including first and second switching devices coupled to each other, and at least one first-type energy storage device (ESD) coupled in parallel with both of the first and second switching devices, the first-type ESD configured to induce a first direct current (DC) voltage. The system also includes a plurality of relays coupled to the first-type ESD, and a charge controller coupled to at least one APLM of the plurality of APLMs and coupled to at least one of an electrical power source and a discharge circuit. The charge controller is configured to alternately charge and discharge the first-type ESD in response to a plurality of switching states including switching states of the plurality of switching devices and the plurality of relays.

Abstract: Systems, devices, and methods for electrical connection between components of wearable heads-up displays are described. A wearable heads-up display can include a first arm and a second arm, bridged by a front frame. The first arm can carry electrical components, the second arm can carry a power source, and the front frame can carry a set of electrically conductive current paths which provide electrical coupling between the power source and the electrical components. The first arm and the second arm can each rotate about a respective hinge relative to the front frame. A flexible, dynamic set of electrically conductive current paths can couple the electrical components in the first arm to the set of electrically conductive current paths in the front frame, and another flexible, dynamic set of electrically conductive current paths can couple the power source in the second arm to the connector in the front frame.

Abstract: Embodiments are directed to managing data in a file system. The file system that includes storage nodes that may be associated with storage volumes that may have a different capacity for storing data. A storage capacity of the file system may be determined based on a number of stripes of data that fit in the file system such that each stripe may be comprised of chunks that have a same chunk storage capacity. Slots in the file system that each match the chunk storage capacity may be determined based on the storage volumes. The chunks may be assigned to the slots in the file system based on the capacity of the storage nodes such that a number of chunks allocated to a same storage volume or a same storage node may be based on protection factor information.

Abstract: In an embodiment, an apparatus includes one or more probes, a tip, a pin, and a measurement device. The one or more probes may be configured for insertion through an aperture in a component. The tip may be slidably engaged with the one or more probes and include a first end configured to contact a first surface of the component. The first end of the tip may be conically shaped. The pin may be slidably engaged with the one or more probes and include a first end configured for insertion into the aperture in the component such that the one or more probes are configured to contact a second surface of the component. The pin may be configured to move between a first position and a second position. An axis of the pin may be substantially aligned with an axis of the tip. The measurement device may be coupled to the tip and configured to measure a value indicating a grip length.

Abstract: A focused treatment tip (FTT) for controlling the evaporation rate and providing targeted delivery of low temperature liquified gases for contact with living tissue includes a contoured body. When filled with liquified gas, the device insulates the gas from waste heat sources, such as the surrounding environment. The device can control the evaporation rate of the liquified gas at the treatment site. The controlled evaporation rate affects the rate of heat transfer from the treated tissue allowing for controlled exposure times and desired outcomes. The device can be used with various application tips to further define the target tissue area to be treated while minimizing collateral damage to surrounding tissue and isolating the gas within the contoured body and focusing heat transfer to the desired treatment area. The device may use transparent materials that make the treatment visible to the operator while the liquified gas is evaporating.

Abstract: Multi-phase-shift control of a power converter is provided. The power converter includes a dual-active-bridge (DAB) converter having a transformer, a first H-bridge coupled to the primary winding of the transformer, and a second H-bridge coupled to the secondary winding of the transformer. The DAB converter is operable to generate two-level and three-level voltage waveforms on the primary winding and on the secondary winding to yield a system which ensures zero-voltage switching and unity power factor over a wide range of input and output voltage levels and power throughputs. In a multi-phase shift (MPS) mode of operation, the DAB converter changes from a two-level voltage in at least one of the windings to a three-level voltage in both windings in response to the instantaneous load being below a predetermined level, resulting in more efficient performance of the DAB converter in light load conditions.

Abstract: A susceptor for use in a processing chamber for supporting a wafer includes a susceptor substrate having a front side and a back side opposite the front side, and a coating layer deposited on the susceptor substrate. The front side has a pocket configured to hold a wafer to be processed in a processing chamber, the pocket being textured with a first pattern. The back side is textured with a second pattern.

Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.