Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: A membrane distillation regenerator can include a first liquid channel through which a first liquid flows at a first temperature, a second liquid channel through which a second liquid flows from the first liquid channel and at a second temperature higher than the first temperature, a condensation cell disposed between the first liquid channel and the second liquid channel, and a permeable membrane disposed between the second liquid channel and the condensation cell. The regenerator can include several distillation stages in which the vapor separated from the second liquid can pass from an evaporation chamber of the second liquid channel through the membrane and into a corresponding condensation chamber of the condensation cell.

Abstract: A tool interchange for a submersible remote operated vehicle (ROV) arm includes a first interchange body that affixes to an ROV arm. A second interchange body is carried by the first interchange body to rotate on a rotation axis. The second interchange body includes a tool mount actuable between gripping an ROV tool to the second interchange body and releasing the ROV tool from the second interchange body. An inductive power coupling part is provided in the tool mount. The inductive power coupling part is presented outwardly in the tool mount opposite the first interchange body, resides on the rotation axis and is fixed with respect to the first interchange body while the second interchange body rotates. The inductive power coupling part is adapted to inductively communicate power with a corresponding inductor power coupling part of the ROV tool when the ROV tool is docked in the tool mount.

Abstract: Provided herein are systems and methods for screening and analyzing compounds based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents. As an example, a system and method can include a computational model that mimics in silico the cereblon protein. Also provided herein are systems and methods for identifying a compound that induces a conformational change in Cereblon, and in particular P98A mutant cereblon.

Abstract: The invention relates to a breathing assistance apparatus that may be configured to reduce the risk of damage to electronics within the apparatus as a result of liquid leaks within the apparatus or impacts to the apparatus. In other forms, the apparatus may be configured to allow for easy assembly and/or safe operation.

Abstract: A liquid desiccant absorption chiller includes an absorber-evaporator and a regenerator. The absorber-evaporator includes a cooling liquid channel through which a cooling liquid is configured to flow, a liquid desiccant channel through which a liquid desiccant is configured to flow, an air-gap cell disposed between the cooling liquid channel and the liquid desiccant channel, a first permeable membrane disposed between the liquid desiccant channel and the air-gap cell, and a second permeable membrane disposed between the second liquid channel and the air-gap cell.

Abstract: A membrane assembly includes a membrane film, and a plurality of tensile support members. The membrane film is configured to transfer heat and moisture between a liquid and air flowing through a LAMEE. The tensile support members are connected to the membrane or a substrate connected to the membrane. And, the tensile support members are in spaced relation to 5 one another and oriented perpendicular to a direction of flow of liquid through the LAMEE.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a pre-cooler upstream and a recovery coil downstream of the evaporative cooler. Outdoor or scavenger air can be conditioned in the evaporative cooler such that the conditioned scavenger air can provide cooling to a cooling fluid circulating through the recovery coil. The reduced-temperature cooling fluid can provide liquid cooling or air cooling for an enclosed space (for example, a data center) or for one or more devices that are enclosed or open to the atmosphere. Given the design and arrangement of the pre-cooler, evaporative cooler and recovery coil in the plenum, the system can operate in multiple modes. The pre-cooler can be configured to circulate a cooling fluid to condition the scavenger air. The pre-cooler fluid circuit can be coupled or decoupled from a process cooling fluid circuit.

Abstract: A specialized slot machine for conducting a wagering tournament game using real time or live action event content are disclosed.

Abstract: Systems and methods for providing dehumidification to an enclosed space can include a dehumidification unit in a supply air plenum that receives return air and a regeneration unit in a scavenger air plenum that receives outdoor air. The system can operate in a wet mode and a dry mode, depending on outdoor air conditions and a relative humidity setpoint for the enclosed space. The dehumidification unit and regeneration unit are both operational in the wet mode to dehumidify the return air and regenerate dilute desiccant. In the dry mode, the dehumidification unit and regeneration unit are not needed, and dry outdoor air can be supplied to the enclosed space. A heat recovery system utilizes waste heat from either return air or scavenger air, depending on the operating mode, to heat the outdoor air before it is supplied to the enclosed space or before it is used for regenerating desiccant.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a recovery coil downstream of the evaporative cooler. The conditioning systems can operate in various modes, including an adiabatic mode and an evaporative mode, and a blended mode between the adiabatic mode and the evaporative mode, depending on environmental conditions. The blended mode can be enabled by a fluid transmission and retention device fluidically connected to the inlet and outlet of the evaporative cooler, the recovery coil outlet, and the heat load. The fluid transmission and retention device can variably distribute the cooling fluid exiting the recovery coil and the cooling fluid exiting the evaporative cooler to one or both of the heat load and the evaporative cooler inlet. In an example, the fluid transmission and retention device includes a manifold. In another example, the fluid transmission and retention device includes one or more tanks.

Abstract: A conditioning system includes a liquid-to-air energy exchanger (LAEE) having a plurality of energy exchange (EX) circuits. The LAEE includes a single liquid panel, an air channel, and a plurality of membranes. The single liquid panel has a 5 plurality of liquid circuits through each of which a liquid is configured to flow. Each of the plurality of liquid circuits has a plurality of closed liquid channels through each of which a liquid is configured to flow without mixing with the liquid flowing through other of the plurality of closed liquid channels. Each of the liquid circuits corresponds to each of the plurality of EX circuits. The air channel is adjacent the 10 liquid panel and air is configured to flow through the air channel from an inlet of the LAEE to an outlet of the LAEE. The air channel extends adjacent all of the plurality of liquid circuits. The plurality of membranes is connected to the liquid panel.

Abstract: Disclosed are systems and methods for conditioning air using a liquid-to-air membrane energy exchanger (LAMEE) as a pre-dryer, in combination with a direct evaporative cooler (DEC). The LAMEE and DEC can be arranged inside a process plenum configured to receive and condition air for delivery to an enclosed space. The LAMEE can circulate a liquid desiccant to remove moisture from the air, before passing the air through the DEC. As a result, the DEC can cool the air to lower temperatures and improve overall efficiency. In an example, a regeneration system can regenerate at least some of the liquid desiccant prior to recirculation through the LAMEE. In an example, the DEC can use removed water recovered in regeneration as make up water for the DEC. In an example, a liquid to air or liquid to liquid heat exchanger can cool the liquid desiccant, prior to recirculation through the LAMEE.

Abstract: Systems and methods for controlling conditions in an enclosed space, such as a data center, or for providing cooling to a device, can include using a Liquid-to-Air Membrane Energy Exchanger (LAMEE) as an evaporative cooler. The LAMEE or exchanger can cool water to the outdoor air wet bulb temperature in a cooling system disposed outside of the enclosed space or device. The reduced-temperature water can be delivered to the enclosed space or device or can cool a coolant that is delivered to the enclosed space or device. The air in the enclosed space, or one or more components in the enclosed space, can be cooled by delivering the reduced-temperature water or coolant to the enclosed space, rather than moving the supply air from the enclosed space to the cooling system. In an example, the cooling system can include one or more cooling coils, upstream or downstream of the LAMEE.

Abstract: Disclosed are systems and methods for conditioning air using a liquid-to-air membrane energy exchanger (LAMEE) as a pre-dryer, in combination with a direct evaporative cooler (DEC). The LAMEE and DEC can be arranged inside a process plenum configured to receive and condition air for delivery to an enclosed space. The LAMEE can circulate a liquid desiccant to remove moisture from the air, before passing the air through the DEC. As a result, the DEC can cool the air to lower temperatures and improve overall efficiency. In an example, a regeneration system can regenerate at least some of the liquid desiccant prior to recirculation through the LAMEE. In an example, the DEC can use removed water recovered in regeneration as make up water for the DEC. In an example, a liquid to air or liquid to liquid heat exchanger can cool the liquid desiccant, prior to recirculation through the LAMEE.

Abstract: A system and method for conducting a wagering tournament game using real time or live action event content are disclosed. An embodiment includes: prompting a plurality of users at a plurality of geographically distributed user platforms to each submit a wager for entry as players into a real time live action wagering tournament game; dividing a plurality of players of the real time live action wagering tournament game into player groups; obtaining a set of real time or live event content via the data network while the plurality of players are playing the real time live action wagering tournament game; ranking each of the players in each player group based on their score; and enabling a pre-determined quantity of highest ranked players from each player group to advance to a next round.

Abstract: A liquid panel assembly configured to be used with an energy exchanger may include a support frame having one or more fluid circuits and at least one membrane secured to the support frame. Each of the fluid circuits may include an inlet channel connected to an outlet channel through one or more flow passages. A liquid is configured to flow through the fluid circuits and contact interior surfaces of the membrane(s). The fluid circuits are configured to at least partially offset liquid hydrostatic pressure with friction loss of the liquid flowing within the fluid circuits to minimize, eliminate, or otherwise reduce pressure within the liquid panel assembly.

Abstract: Systems and methods for controlling conditions in an enclosed space, such as a data center, or for providing cooling to a device, can include using a Liquid-to-Air Membrane Energy Exchanger (LAMEE) as an evaporative cooler. The LAMEE or exchanger can cool water to the outdoor air wet bulb temperature in a cooling system disposed outside of the enclosed space or device. The reduced-temperature water can be delivered to the enclosed space or device or can cool a coolant that is delivered to the enclosed space or device. The air in the enclosed space, or one or more components in the enclosed space, can be cooled by delivering the reduced-temperature water or coolant to the enclosed space, rather than moving the supply air from the enclosed space to the cooling system. In an example, the cooling system can include one or more cooling coils, upstream or downstream of the LAMEE.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a recovery coil downstream of the evaporative cooler. The conditioning systems can operate in various modes, including an adiabatic mode and an evaporative mode, and a blended mode between the adiabatic mode and the evaporative mode, depending on environmental conditions. The blended mode can be enabled by a fluid transmission and retention device fluidically connected to the inlet and outlet of the evaporative cooler, the recovery coil outlet, and the heat load. The fluid transmission and retention device can variably distribute the cooling fluid exiting the recovery coil and the cooling fluid exiting the evaporative cooler to one or both of the heat load and the evaporative cooler inlet. In an example, the fluid transmission and retention device includes a manifold. In another example, the fluid transmission and retention device includes one or more tanks.

Abstract: A hybrid system and method for conditioning air for an enclosed space can include a direct cooling system in combination with an indirect cooling system. The hybrid system can use direct cooling when ambient temperature and humidity levels are such that 100% outdoor air can be delivered to the enclosed space. The hybrid system can use indirect cooling when 100% of the return air can be conditioned using an external cooling unit and then returned to the enclosed space as supply air. The external cooling unit can include an evaporative cooler and operate in a dry mode and a wet mode. The external cooling unit can produce a reduced temperature cooling fluid and provide liquid cooling to the air when the system is operating in the indirect mode, and in some cases, in the direct mode. The hybrid system can operate in a mixed mode in which the external cooling unit is off and a mix of return air and outdoor air can be delivered to the enclosed space.