Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a recovery coil downstream of the evaporative cooler. The conditioning systems can operate in various modes, including an adiabatic mode and an evaporative mode, depending on outdoor air conditions. The systems can operate in a blended mode between the adiabatic mode and the evaporative mode by varying the distribution of return water from the recovery coil into at least partially isolated sections of a storage tank, and selectively directing cold water from the evaporative cooler into the tank. The mix of warm and cold water exiting the tank can be varied to maintain the cold-water supply at or near a set point temperature for the heat load. In an example, the systems can include a pre-cooler in the plenum upstream of the evaporative cooler for pre-conditioning the scavenger air.

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Abstract: A hybrid evaporative cooler system can include an evaporative cooler, a cooling coil, and a controller. The evaporative cooler can be located in an airstream and the cooling coil can be located in the airstream downstream of the evaporative cooler. The cooling coil can be configured to receive a process fluid from a source. The controller can be configured to operate the hybrid evaporative cooler system in a dry mode on condition that the leaving process fluid temperature set point is greater than the minimum supply fluid temperature.

Abstract: Systems and methods for providing dehumidification to an enclosed space can include a dehumidification unit in a supply air plenum that receives return air and a regeneration unit in a scavenger air plenum that receives outdoor air. The system can operate in a wet mode and a dry mode, depending on outdoor air conditions and a relative humidity setpoint for the enclosed space. The dehumidification unit and regeneration unit are both operational in the wet mode to dehumidify the return air and regenerate dilute desiccant. In the dry mode, the dehumidification unit and regeneration unit are not needed, and dry outdoor air can be supplied to the enclosed space. A heat recovery system utilizes waste heat from either return air or scavenger air, depending on the operating mode, to heat the outdoor air before it is supplied to the enclosed space or before it is used for regenerating desiccant.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a pre-cooler upstream and a recovery coil downstream of the evaporative cooler. Outdoor or scavenger air can be conditioned in the evaporative cooler such that the conditioned scavenger air can provide cooling to a cooling fluid circulating through the recovery coil. The reduced-temperature cooling fluid can provide liquid cooling or air cooling for an enclosed space (for example, a data center) or for one or more devices that are enclosed or open to the atmosphere. Given the design and arrangement of the pre-cooler, evaporative cooler and recovery coil in the plenum, the system can operate in multiple modes. The pre-cooler can be configured to circulate a cooling fluid to condition the scavenger air. The pre-cooler fluid circuit can be coupled or decoupled from a process cooling fluid circuit.

Abstract: Systems and methods for controlling conditions in an enclosed space, such as a data center, or for providing cooling to a device, can include using a Liquid-to-Air Membrane Energy Exchanger (LAMEE) as an evaporative cooler. The LAMEE or exchanger can cool water to the outdoor air wet bulb temperature in a cooling system disposed outside of the enclosed space or device. The reduced-temperature water can be delivered to the enclosed space or device or can cool a coolant that is delivered to the enclosed space or device. The air in the enclosed space, or one or more components in the enclosed space, can be cooled by delivering the reduced-temperature water or coolant to the enclosed space, rather than moving the supply air from the enclosed space to the cooling system. In an example, the cooling system can include one or more cooling coils, upstream or downstream of the LAMEE.

Abstract: Systems and methods for controlling conditions in an enclosed space, such as a data center, or for providing cooling to a device, can include using a Liquid-to-Air Membrane Energy Exchanger (LAMEE) as an evaporative cooler. The LAMEE or exchanger can cool water to the outdoor air wet bulb temperature in a cooling system disposed outside of the enclosed space or device. The reduced-temperature water can be delivered to the enclosed space or device or can cool a coolant that is delivered to the enclosed space or device. The air in the enclosed space, or one or more components in the enclosed space, can be cooled by delivering the reduced-temperature water or coolant to the enclosed space, rather than moving the supply air from the enclosed space to the cooling system. In an example, the cooling system can include one or more cooling coils, upstream or downstream of the LAMEE.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a pre-cooler upstream and a recovery coil downstream of the evaporative cooler. Outdoor or scavenger air can be conditioned in the evaporative cooler such that the conditioned scavenger air can provide cooling to a cooling fluid circulating through the recovery coil. The reduced-temperature cooling fluid can provide liquid cooling or air cooling for an enclosed space (for example, a data center) or for one or more devices that are enclosed or open to the atmosphere. Given the design and arrangement of the pre-cooler, evaporative cooler and recovery coil in the plenum, the system can operate in multiple modes. The pre-cooler can be configured to circulate a cooling fluid to condition the scavenger air. The pre-cooler fluid circuit can be coupled or decoupled from a process cooling fluid circuit.

Abstract: A conditioning system includes a first plenum and a second plenum. The second plenum receives heated air from an enclosed space and supplies cooled air to the space. The system also includes a first liquid-to-air membrane energy exchanger (LAMEE1) arranged inside the first plenum. LAMEE1 is configured to use a liquid desiccant to lower an enthalpy of the first air stream. A LAMEE2 is arranged inside the first plenum downstream of LAMEE1. LAMEE2 is configured to use the first air stream to evaporatively cool water flowing through LAMEE2. A first LAHX (LAHX1) is arranged inside the second plenum. LAHX1 is configured to directly and sensibly cool the second air stream using a first cooling fluid. A second LAHX (LAHX2) is in fluid communication with LAMEE1 and is configured to receive the liquid desiccant from LAMEE1 and cool the liquid desiccant using outdoor air.

Abstract: A liquid panel assembly configured to be used with an energy exchanger may include a support frame having one or more fluid circuits and at least one membrane secured to the support frame. Each of the fluid circuits may include an inlet channel connected to an outlet channel through one or more flow passages. A liquid is configured to flow through the fluid circuits and contact interior surfaces of the membrane(s). The fluid circuits are configured to at least partially offset liquid hydrostatic pressure with friction loss of the liquid flowing within the fluid circuits to minimize, eliminate, or otherwise reduce pressure within the liquid panel assembly.

Abstract: A liquid panel assembly configured to be used with an energy exchanger may include a support frame having one or more fluid circuits and at least one membrane secured to the support frame. Each of the fluid circuits may include an inlet channel connected to an outlet channel through one or more flow passages. A liquid is configured to flow through the fluid circuits and contact interior surfaces of the membrane(s). The fluid circuits are configured to at least partially offset liquid hydrostatic pressure with friction loss of the liquid flowing within the fluid circuits to minimize, eliminate, or otherwise reduce pressure within the liquid panel assembly.

Abstract: Systems and methods for controlling temperature in an enclosed space can include an air-to-air heat exchanger (AAHX) and a direct evaporative cooler (DEC). The DEC can be located in a scavenger or outdoor air stream such that the DEC cools the outdoor air, which is then used to cool or reject heat from a process air stream passing through the AAHX. In an example, the AAHX can be a sensible wheel. In another example, the AAHX can be a counter-flow flat plate. The system can operate in various modes, including an economizer mode and an evaporation mode, depending, in part, on the outdoor air conditions and a load on the system. In some examples, the system can include a DX coil to provide additional cooling to the process air in another operating mode.

Abstract: A complex comprises a CRBN having a europium-anti-his antibody on the N-terminus of the CRBN, and a Cy5-conjugated small molecule, wherein the Cy5-conjugated small molecule binds the CRBN, and uses thereof for identifying therapeutic compounds.

Abstract: Systems and methods are disclosed herein for a three-fluid liquid-to-air membrane energy exchanger (LAMEE) to condition air (a first overall fluid). A liquid panel assembly used in the LAMEE can include a first fluid circuit for a first cooling fluid (a second overall fluid) and a second fluid circuit for a second cooling fluid (a third overall fluid). The first cooling fluid, also referred to herein as a desiccant, can be configured to circulate through the liquid panel assembly and condition an air stream passing through the LAMEE. The second cooling fluid, also referred to herein as a coolant, can be configured to also circulate through the panel assembly and reject heat from the first cooling fluid. The second cooling fluid can increase the cooling capacity and overall performance of the LAMEE. The first and second cooling fluids can be separate from each other during circulation through the panel assembly.

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Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a recovery coil downstream of the evaporative cooler. The conditioning systems can operate in various modes, including an adiabatic mode and an evaporative mode, depending on outdoor air conditions. The systems can operate in a blended mode between the adiabatic mode and the evaporative mode by varying the distribution of return water from the recovery coil into at least partially isolated sections of a storage tank, and selectively directing cold water from the evaporative cooler into the tank. The mix of warm and cold water exiting the tank can be varied to maintain the cold-water supply at or near a set point temperature for the heat load. In an example, the systems can include a pre-cooler in the plenum upstream of the evaporative cooler for pre-conditioning the scavenger air.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a recovery coil downstream of the evaporative cooler. The conditioning systems can operate in various modes, including an adiabatic mode and an evaporative mode, and a blended mode between the adiabatic mode and the evaporative mode, depending on environmental conditions. The blended mode can be enabled by a fluid transmission and retention device fluidically connected to the inlet and outlet of the evaporative cooler, the recovery coil outlet, and the heat load. The fluid transmission and retention device can variably distribute the cooling fluid exiting the recovery coil and the cooling fluid exiting the evaporative cooler to one or both of the heat load and the evaporative cooler inlet. In an example, the fluid transmission and retention device includes a manifold. In another example, the fluid transmission and retention device includes one or more tanks.

Abstract: Systems and methods for controlling conditions in an enclosed space can include an integral make-up air system that can be arranged in the interior of the housing for an air conditioning system that uses scavenger air in an air-to-air heat exchanger (AAHX) to condition process air from an enclosed space. The make-up air system can take replenishment air from outside the air conditioning system and deliver it into the process air stream. The make-up air system can include at least one heating or cooling device to condition the replenishment air before the replenishment air mixes with the process air. In an example, the make-up air system can include a DX coil to selectively cool and dehumidify the replenishment air. The make-up air system can include a humidifier arranged in the flow path of process air between the process air inlet and the AAHX to selectively add humidity to the process air.

Abstract: A complex comprises a CRBN having a europium-anti-his antibody on the N-terminus of the CRBN, and a Cy5-conjugated small molecule, wherein the Cy5-conjugated small molecule binds the CRBN, and uses thereof for identifying therapeutic compounds.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a pre-cooler upstream and a recovery coil downstream of the evaporative cooler. Outdoor or scavenger air can be conditioned in the evaporative cooler such that the conditioned scavenger air can provide cooling to a cooling fluid circulating through the recovery coil. The reduced-temperature cooling fluid can provide liquid cooling or air cooling for an enclosed space (for example, a data center) or for one or more devices that are enclosed or open to the atmosphere. Given the design and arrangement of the pre-cooler, evaporative cooler and recovery coil in the plenum, the system can operate in multiple modes. The pre-cooler can be configured to circulate a cooling fluid to condition the scavenger air. The pre-cooler fluid circuit can be coupled or de-coupled from a process cooling fluid circuit.