Abstract: Systems and methods for controlling conditions in an enclosed space can include an integral make-up air system that can be arranged in the interior of the housing for an air conditioning system that uses scavenger air in an air-to-air heat exchanger (AAHX) to condition process air from an enclosed space. The make-up air system can take replenishment air from outside the air conditioning system and deliver it into the process air stream. The make-up air system can include at least one heating or cooling device to condition the replenishment air before the replenishment air mixes with the process air. In an example, the make-up air system can include a DX coil to selectively cool and dehumidify the replenishment air. The make-up air system can include a humidifier arranged in the flow path of process air between the process air inlet and the AAHX to selectively add humidity to the process air.

Abstract: A complex comprises a CRBN having a europium-anti-his antibody on the N-terminus of the CRBN, and a Cy5-conjugated small molecule, wherein the Cy5-conjugated small molecule binds the CRBN, and uses thereof for identifying therapeutic compounds.

Abstract: Systems and methods are disclosed herein for a three-fluid liquid-to-air membrane energy exchanger (LAMEE) to condition air (a first overall fluid). A liquid panel assembly used in the LAMEE can include a first fluid circuit for a first cooling fluid (a second overall fluid) and a second fluid circuit for a second cooling fluid (a third overall fluid). The first cooling fluid, also referred to herein as a desiccant, can be configured to circulate through the liquid panel assembly and condition an air stream passing through the LAMEE. The second cooling fluid, also referred to herein as a coolant, can be configured to also circulate through the panel assembly and reject heat from the first cooling fluid. The second cooling fluid can increase the cooling capacity and overall performance of the LAMEE. The first and second cooling fluids can be separate from each other during circulation through the panel assembly.

Abstract: Systems and methods for controlling conditions in an enclosed space, such as a data center, or for providing cooling to a device, can include using a Liquid-to-Air Membrane Energy Exchanger (LAMEE) as an evaporative cooler. The LAMEE or exchanger can cool water to the outdoor air wet bulb temperature in a cooling system disposed outside of the enclosed space or device. The reduced-temperature water can be delivered to the enclosed space or device or can cool a coolant that is delivered to the enclosed space or device. The air in the enclosed space, or one or more components in the enclosed space, can be cooled by delivering the reduced-temperature water or coolant to the enclosed space, rather than moving the supply air from the enclosed space to the cooling system. In an example, the cooling system can include one or more cooling coils, upstream or downstream of the LAMEE.

Abstract: An example system is configured to control conditions in an enclosed space. The system includes scavenger and process plenums, a liquid-to-air membrane energy exchanger (LAMEE), a first liquid-to-air heat exchanger (LAHX), a second LAHX, and a fluid circuit The scavenger plenum is configured to direct scavenger air from a scavenger inlet to a scavenger outlet. The process plenum is sealed from the scavenger plenum and is configured to direct process air from a process inlet to a process outlet The process inlet receives heated air from the space and the process outlet supplies cooled air to the space. The LAMEE is arranged inside the scavenger plenum. The LAMEE is configured to use the scavenger air to evaporatively cool a first fluid flowing through the LAMEE. The temperature of the first fluid at a LAMEE outlet is lower than the temperature of the first fluid at a LAMEE inlet. The first LAHX is arranged inside the process plenum.

Abstract: Conditioning systems and methods for providing cooling to a heat load can include an evaporative cooler arranged in a scavenger plenum with a pre-cooler upstream and a recovery coil downstream of the evaporative cooler. Outdoor or scavenger air can be conditioned in the evaporative cooler such that the conditioned scavenger air can provide cooling to a cooling fluid circulating through the recovery coil. The reduced-temperature cooling fluid can provide liquid cooling or air cooling for an enclosed space (for example, a data center) or for one or more devices that are enclosed or open to the atmosphere. Given the design and arrangement of the pre-cooler, evaporative cooler and recovery coil in the plenum, the system can operate in multiple modes. The pre-cooler can be configured to circulate a cooling fluid to condition the scavenger air. The pre-cooler fluid circuit can be coupled or decoupled from a process cooling fluid circuit.

Abstract: Embodiments of the present disclosure provide a system and method for providing conditioned air to at least one enclosed structure. The system may include at least one conditioning module configured to provide conditioned air to the at least one enclosed structure. The conditioning module(s) may include a conditioning energy exchanger. The conditioning module(s) is configured to circulate desiccant through a desiccant circuit to condition air passing through the conditioning energy exchanger. The conditioning module(s) may be configured to receive at least one of concentrated desiccant or diluted desiccant in order to vary temperature or concentration of the desiccant circulating through the desiccant circuit.

Abstract: An improved pneumatic jetting valve includes a housing with first and second chambers. A pneumatic piston is enclosed between the chambers. First and second solenoid valves are configured to respectively supply air pressure to the chambers and to exhaust the chambers. A controller is operable to regulate the pressurization and venting of the chambers. The controller controls the timing of control signals for the first and second solenoid valves to control the overlap time during which both the first and second chambers are pressurized. By controlling this overlap time, the controller controls the speed of the drive pin of the jetting valve and thereby the speed at which the valve closes to jet a droplet of material. This allows a valve speed to be selected that is most appropriate for the viscosity of the material being jetted. Numerous new methods for utilizing the improved jetting valve and system are disclosed.

Abstract: A liquid panel assembly configured to be used with an energy exchanger may include a support frame having one or more fluid circuits and at least one membrane secured to the support frame. Each of the fluid circuits may include an inlet channel connected to an outlet channel through one or more flow passages. A liquid is configured to flow through the fluid circuits and contact interior surfaces of the membrane(s). The fluid circuits are configured to at least partially offset liquid hydrostatic pressure with friction loss of the liquid flowing within the fluid circuits to minimize, eliminate, or otherwise reduce pressure within the liquid panel assembly.

Abstract: In one embodiment, the present invention provides a central core element for a reverse osmosis separator assembly, the central core element comprising a pair of central core element components, each of said core element components comprising at least one porous exhaust conduit and at least one friction coupling, the friction couplings being configured to join said core element components to form a central core element defining a cavity configured to accommodate a first portion of a membrane stack assembly; wherein each core element component comprises a first section defining an exhaust cavity and a second section comprising a porous exhaust conduit, wherein said porous exhaust conduit comprises a removable wall member configured to form a substantial portion of a porous exhaust conduit wall.

Abstract: A liquid panel assembly configured to be used with an energy exchanger may include a support frame having one or more fluid circuits and at least one membrane secured to the support frame. Each of the fluid circuits may include an inlet channel connected to an outlet channel through one or more flow passages. A liquid is configured to flow through the fluid circuits and contact interior surfaces of the membrane(s). The fluid circuits are configured to at least partially offset liquid hydrostatic pressure with friction loss of the liquid flowing within the fluid circuits to minimize, eliminate, or otherwise reduce pressure within the liquid panel assembly.

Abstract: In one aspect, a method includes: receiving information defining a plurality of different actions that may be performed by users; receiving information indicating a relative frequency at which each of the different actions was performed by each of a plurality of users over each of one or more periods of time; determining a plurality of different characteristic behaviors based at least in part on the information indicating the relative frequency at which each of the different actions was performed by each of the plurality of users over each of one or more periods of time, wherein each one of the different characteristic behaviors defines a relative frequency of performance of each of the different actions; receiving information indicating a relative frequency at which each of the different actions was performed by a user over a period of time; and determining a representation of the relative frequency at which each of the different actions was performed by the user over the period of time as a weighted combina

Abstract: A specialized slot machine for conducting a wagering game using real time or live action event content are disclosed.

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to Programmed Death-1 (PD-1) and modulate the expression and/or activity of PD-1.

Abstract: A specialized slot machine for conducting a wagering game using real time or live action event content are disclosed.

Abstract: Embodiments of the present disclosure provide a system and method for providing conditioned air to at least one enclosed structure. The system may include at least one conditioning module configured to provide conditioned air to the at least one enclosed structure. The conditioning module(s) may include a conditioning energy exchanger. The conditioning module(s) is configured to circulate desiccant through a desiccant circuit to condition air passing through the conditioning energy exchanger. The conditioning module(s) may be configured to receive at least one of concentrated desiccant or diluted desiccant in order to vary temperature or concentration of the desiccant circulating through the desiccant circuit.

Abstract: A scanning probe nanolithography system comprising a probe to create nanostructures line (60) by line through writing said nanostructures (74) pixel by pixel along lines (61) on a sample. A positioning system is adapted to provide a positioning of the probe at a sequence of predetermined positions to the sample and its surface towards the probe and a control unit (50) is provided to control the positioning system for positioning the probe for a pixel-wise writing of said lines (61) through a writing unit. It further comprises a sensor unit adapted to detect a predetermined property of the written nanostructure (74), the sensor unit being connected to the control unit to adapt the control signals to be provided to the writing unit for writing the following line (61; 62) based on the measured signals (65; 66) of the predetermined property.

Abstract: A specialized slot machine for conducting a wagering game using real time or live action event content are disclosed.

Abstract: A liquid to air membrane energy exchanger (LAMEE) can be used as part of a heating and cooling system to transfer heat and moisture between a liquid desiccant and an air stream to condition the temperature and humidity of the air flowing through the LAMEE. The membrane can be a non-porous film having selective permeability for water, but not for other constituents that form the liquid desiccant. The non-porous membrane can allow for use of liquid desiccants, such as glycols, that had been previously determined to be unacceptable or undesirable in these types of applications. In an example, the membrane can be an ion-exchange membrane or pervaporation membrane.

Abstract: Systems and methods for controlling temperature in an enclosed space can include an air-to-air heat exchanger (AAHX) and a direct evaporative cooler (DEC). The DEC can be located in a scavenger or outdoor air stream such that the DEC cools the outdoor air, which is then used to cool or reject heat from a process air stream passing through the AAHX. In an example, the AAHX can be a sensible wheel. In another example, the AAHX can be a counter-flow flat plate. The system can operate in various modes, including an economizer mode and an evaporation mode, depending, in part, on the outdoor air conditions and a load on the system. In some examples, the system can include a DX coil to provide additional cooling to the process air in another operating mode.