Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A semiconductor package includes a first interposer, a second interposer, a first die, a second die and at least one bridge structure. The first interposer and the second interposer are embedded by a first dielectric encapsulation. The first die is disposed over and electrically connected to the first interposer. The second die is disposed over and electrically connected to the second interposer. The at least one bridge structure is disposed between the first die and the second die.

Abstract: A semiconductor device includes a circuit substrate, a semiconductor package, and a metallic cover. The semiconductor package is disposed on the circuit substrate. The metallic cover is disposed over the semiconductor package and over the circuit substrate. The metallic cover comprises a lid and outer flanges. The lid overlies the semiconductor package. The outer flanges are disposed at edges of the lid, are connected with the lid, extend from the lid towards the circuit substrate, and face side surfaces of the semiconductor package. The lid has a first region that is located over the semiconductor package and is thicker than a second region that is located outside a footprint of the semiconductor package.

Abstract: The invention relates to a shared storage space access method, device and system and a storage medium. The product comprises a control module. The control module comprises an instruction cache unit, an instruction processing unit and a storage queue unit. The instruction caching unit is used for storing a calculation instruction associated with the artificial neural network operation; the instruction processing unit is used for analyzing the calculation instruction to obtain a plurality of operation instructions; the storage queue unit is used for storing an instruction queue, and the instruction queue comprises a plurality of operation instructions or calculation instructions to be executed according to the front-back sequence of the queue. Through the method or the product, the access efficiency of the storage space can be improved.

Abstract: A system and method are disclosed for a vehicle that comprises one or more sensors configured to obtain information indicating a physical state of a baby. A wireless transceiver may be included and in communication with a mobile device. The transceiver may be configured to connect mobile device with a camera configured to monitor the baby. A controller may also be in communication with the one or more sensors and the wireless transceiver. The controller may be configured to determine the physical state of the baby utilizing the information obtained from the one or more sensors. The controller may also be configured activate one or more vehicle systems in response to the physical state of the baby and to output on a vehicle display or the mobile device a notification to a user indicating the physical state of the baby.

Abstract: A system in a vehicle, comprising one or more physiological sensors configured to obtain stress-load data indicating a stress load of an occupant of the vehicle, a controller in communication with the one or more physiological sensors, wherein the controller is configured to determine a stress load of the occupant utilizing at least the stress-load data and output an instruction to execute a vehicle driving-dynamics features when the stress load exceeds a threshold, wherein the vehicle driving-dynamics features includes adjusting an active suspension of the vehicle.

Abstract: A fusion protein, which is characterized in that the fusion protein is composed by interleukin-2 (IL-2) being fused with and linked to an anti-human epithelial cell adhesion molecule (EpCAM) single-chain antibody. Further provided by the present solution is a use of the fusion protein in the preparation of a drug for treating tumors.

Abstract: A system for monitoring vehicle drive states and transitioning between human drive control and autonomous drive control based on the vehicle drive states. The system includes a human/autonomous drive status and transition module. The module is configured to: receive data from an autonomous drive module and determine a drive state of the autonomous drive module based on the data received from the autonomous drive module; receive data from a driver status monitor (DSM) to determine a drive state of a human driver; and transition between human drive control and autonomous drive control by the autonomous drive module, and vice-versa, based on the determined drive states of the human driver and the autonomous drive module.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: A system in a vehicle includes one or more sensors configured to obtain input from an occupant of the vehicle. The system also includes a controller in communication with the one or more sensors, wherein the controller is configured to, receive the input from the one or more sensors, determine a mood of the occupant utilizing at least the input, and output a solution to a vehicle display in response to the mood of the occupant.

Abstract: A vehicle system in a vehicle, comprising a first sensor configured to survey an environment proximate to the vehicle, including an object outside of the vehicle, a second sensor located within a vehicle cabin and configured to obtain data indicative of facial information of an occupant of the vehicle, and a processor in communication with the first and second sensors and programmed to output information regarding the object on a display of the vehicle system in response to the data indicative of the facial information indicating that the occupant is viewing the object outside of the vehicle.

Abstract: Embodiments of the present disclosure include a semiconductor device and methods of forming a semiconductor device. An embodiment is a method of forming a semiconductor device, the method comprising forming a conductive pad in a first substrate, forming an interconnecting structure over the conductive pad and the first substrate, the interconnecting structure comprising a plurality of metal layers disposed in a plurality of dielectric layers, bonding a die to a first side of the interconnecting structure, and etching the first substrate from a second side of the interconnecting structure, the etching exposing a portion of the conductive pad.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: A system in a vehicle includes one or more sensors configured to obtain input from an occupant of the vehicle. The system also includes a controller in communication with the one or more sensors, wherein the controller is configured to, receive the input from the one or more sensors, determine a mood of the occupant utilizing at least the input, and output a solution to a vehicle display in response to the mood of the occupant.

Abstract: Board substrates, three-dimensional integrated circuit structures and methods of forming the same are disclosed. A board substrate includes a core layer, a first build-up layer, a second build-up layer, a first group of bumps, a second first group of bumps and at least one first underfill blocking wall. The first build-up layer and the second build-up layer are disposed on opposite sides of the core layer. The first group of bumps is disposed over the first build-up layer. The second first group of bumps is disposed over the first build-up layer. The at least one first underfill blocking wall is disposed over the first build-up layer and between the first group of bumps and the second group of bumps.

Abstract: A system and method are disclosed for a vehicle that comprises one or more sensors configured to obtain information indicating a physical state of a baby. A wireless transceiver may be included and in communication with a mobile device. The transceiver may be configured to connect mobile device with a camera configured to monitor the baby. A controller may also be in communication with the one or more sensors and the wireless transceiver. The controller may be configured to determine the physical state of the baby utilizing the information obtained from the one or more sensors. The controller may also be configured activate one or more vehicle systems in response to the physical state of the baby and to output on a vehicle display or the mobile device a notification to a user indicating the physical state of the baby.

Abstract: A system in a vehicle comprising one or more sensors configured to obtain cognitive-load data indicating a cognitive load of an occupant of the vehicle, a controller in communication with the one or more sensors, wherein the controller is configured to determine a cognitive load of the occupant utilizing at least the cognitive-load data in response to an initiation of a video conference session, and output on a vehicle display a first user interface in connection with the video conference session when the cognitive load exceeds a threshold and a second user interface in connection with the video conference session when the cognitive load is below a threshold, wherein the second user interface includes video of the video conference session and the first user interface excludes video of the video conference session.

Abstract: A system in a vehicle, comprising one or more cameras configured to obtain facial recognition information based upon facial expressions of an occupant of the vehicle, and a controller in communication with the one or more cameras, wherein the controller is configured to determine the mood of the occupant utilizing at least the facial recognition information, and output an instruction to execute an activation or adjustment of a vehicle driving feature associated with the mood of the occupant.

Abstract: A vehicle system in a host vehicle, comprising a vehicle transceiver located in the host vehicle and configured to receive from a remote server a selectable maneuver in response to data indicative of a driving path of one or more remote vehicles identifying one or more hazards. The system may include a processor in communication the vehicle transceiver and programmed to output one or more selectable maneuvers responsive to the data indicative of the driving path of one or more remote vehicles in response to the data indicative of the driving path identifies one or more hazards in a vicinity of the host vehicle, and a display in communication with the processor and configured to display the one or more selectable maneuvers.

Abstract: A system in a vehicle, comprising one or more physiological sensors configured to obtain stress-load data indicating a stress load of an occupant of the vehicle, a controller in communication with the one or more physiological sensors, wherein the controller is configured to determine a stress load of the occupant utilizing at least the stress-load data and output an instruction to execute a vehicle driving-dynamics features when the stress load exceeds a threshold, wherein the vehicle driving-dynamics features includes adjusting an active suspension of the vehicle.