Abstract: The present disclosure relates to a stable, reproducible and bioequivalent apixaban compositions, wherein the composition comprising apixaban having a D90 particle size of more than 100 microns, preferably between 300 and 1000 microns, and more preferably between 350 and 800 microns, and further comprising one or more pharmaceutically acceptable excipients. The present disclosure further provides a process for preparation of a pharmaceutical composition comprising apixaban by wet granulation.

Abstract: A system and method for managing software services is provided. The method includes receiving a query from a client device, by a processing unit, for accessing software package corresponding to at least one building block stored in a repository, wherein the building block is a software component associated with a software service, configured for reuse in a plurality of engineering applications. The method further includes identifying the software package corresponding to the building block from the repository based on the query. The method further includes providing access to the software package corresponding to the building block, on the client device, through an integrated development environment.

Abstract: Described herein are systems and methods that detect an electromagnetic signal in a constant interference environment. In one embodiment, the electromagnetic signal is a light signal. A constant interference detector may detect false signal “hits” generated by constant interference, such as bright light saturation, from valid signals. The constant interference detector determines if there is constant interference for a time period that is greater than a time period of the valid signal. In one embodiment, if a received signal exceeds a programmable threshold value for a programmable period of time, when compared to previously stored ambient light, a control signal is generated to inform the next higher network layer of a sudden change in ambient light. This control signal can be used to either discard the present return or process the signal in a different way. A constant interference detector may be a component of a LIDAR system.

Abstract: An apparatus includes a memory and a processor. The memory stores a machine learning algorithm configured to select between forwarding a request to an agent device and transmitting an automatically generated reply to the request. The processor receives feedback for a decision made by the algorithm, indicating whether the automatically generated reply includes the information sought by the request. If the algorithm decided to forward the request to the agent device, a reward is assigned to feedback that indicates that the reply does not include the information, while a punishment is assigned to feedback that indicates that the reply includes the information. If the algorithm decided to transmit the reply, a reward is assigned to feedback that indicates that the reply includes the information, and a punishment is assigned to feedback that indicates that the reply does not include the information. The processor updates the algorithm using the reward/punishment.

Abstract: An apparatus includes a memory and processor. The memory stores previous requests and corresponding previous responses. The processor determines that a user device transmitted a new voice request, converts the voice request into a first set of text, and transmits the text to an agent device. The processor applies the machine learning algorithm to the first set of text to generate suggested responses, by identifying patterns shared by the first set of text and a subset of the previous requests that are associated with the suggested responses. The processor transmits the suggested responses to the agent device. The processor then determines that the agent device transmitted voice signals responding to the new request. The processor converts these voice signals into a second set of text. The processor stores the first set of text as a previous request, and the second set of text as a corresponding previous response.

Abstract: First, second, and third threshold limits are configured. The first threshold limit corresponds to a data change at which a backup of a client should be triggered. The second threshold limit corresponds to a maximum time interval at which the backup should be triggered. The third threshold limit corresponds to a utilization of resources at the client above which the backup should not be triggered. An amount of data change since a last backup, an elapsed time, and level of resource utilization at the client is monitored. A determination is made that at least one of the amount of data change has reached the first threshold limit or the elapsed time has reached the second threshold limit. The backup of the client is prevented from occurring because the level of resource utilization at the client is above the third threshold limit.

Abstract: The present disclosure relates generally to systems and methods for configuring architectures for a sensor, and more particularly for light detection and ranging (hereinafter, “LIDAR”) systems based on ASIC sensor architectures supporting autonomous navigation systems. Effective ASIC sensor architecture can enable an improved correlation between sensor data as well as configurability and responsiveness of the system to its surrounding environment and avoid any unnecessary delay within the decision-making process that may result in a failure of the autonomous driving system. It may be essential to integrated multiple functions within an electronic module and implement the functionality with one or more ASICs.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.

Abstract: An eye tracking system configured to: receive a plurality of right-eye-images of a right eye of a user; receive a plurality of left-eye-images of a left eye of a user, each left-eye-image corresponding to a right-eye-image in the plurality of right-eye-images; detect a pupil and determine an associated pupil-signal, for each of the plurality of right-eye-images and each of the plurality of left-eye-images; calculate a right-eye-pupil-variation of the pupil-signals for the plurality of right-eye-images and a left-eye-pupil-variation of the pupil-signals for the plurality of left-eye-images; and determine a right-eye-weighting and a left-eye-weighting based on the right-eye-pupil-variation and the left-eye-pupil-variation.

Abstract: A single-ended receiver is coupled to an input-output (I/O) pin of a command and address (CA) bus. The receiver is configurable with dual-mode I/O support to operate the CA bus in a low-swing mode and a high-swing mode. The receiver is configurable to receive a first command on the I/O pin while in the high-swing mode, initiate calibration of the slave device to operate in the low-swing mode in response to the first command, switch the slave device to operate in the low-swing mode while the CA bus remains active, and to receive a second command on the I/O pin while in the low-swing mode.

Abstract: A pharmaceutical composition containing cinacalcet or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. A pharmaceutical composition containing cinacalcet or pharmaceutically acceptable salts thereof having a particle size distribution D90 equal to or less than 20 ?m, D50 equal to or less than 10 ?m, and D10 equal to or less than 5 ?m and one or more and binders in an amount of 0.9% w/w or less, relative to the total weight of composition, where the composition is not free of binder and that the total amount of binder does not exceed 0.9% w/w relative to the total weight of the composition.

Abstract: Described herein are systems and methods that create a capacitive link based on a rotating cylinder capacitor. A cylindrical rotor rotates around a shaft and maintains an air gap between the cylindrical rotor and the shaft and to create one or more air gap capacitors. A first subsystem, comprising a light detection and ranging components, is coupled to the rotor. A second sub-subsystem, comprising data analysis functions, is coupled to the shaft. The first subsystem and the second subsystem are coupled via capacitive links created by the air gap capacitors. The communication signaling utilized on the capacitive links may be bi-directional and differential signaling. The first subsystem and the second subsystem may comprise a LIDAR light detection and ranging system. The second subsystem may power the first subsystem via inductive coupling.

Abstract: Images of an eye are captured by a camera. For each of the images, gaze data is obtained and a position of a pupil center is estimated in the image. The gaze data indicates a gaze point and/or gaze direction of the eye when the image was captured. A mapping is calibrated using the obtained gaze data and the estimated positions of the pupil center. The mapping maps positions of the pupil center in images captured by the camera to gaze points at a surface, or to gaze directions. A further image of the eye is captured by the camera. A position of the pupil center is estimated in the further image. Gaze tracking is performed using the calibrated mapping and the estimated position of the pupil center in the further image. These steps may for example be performed at a HMD.

Abstract: A mother board with a central processing unit and two riser slots configured to cooperate with one riser card for connecting two expansion cards to the mother board. The first riser slot and the second riser slot may be connected by metal traces to the central processing unit, and the two riser slots may be spaced apart by a distance greater than 8 cm.

Abstract: An electronic device configured to be mounted in a housing of a cluster, the device comprising a rear body housing at least one mother board configured to be powered by the cluster, a front tray housing at least one electronic board having at least one socket, the front tray comprising at least one fastening member for mounting an expansion card having an edge connector and a fastening portion, the electronic board being connected to the mother board by at least one flexible cable, the front tray being mounted slidable relatively from the rear body between a close position and an open position in which the front tray is at least partially removed from the cluster housing while keeping the rear body into the cluster housing so that an expansion card can be mounted/unmounted from the electronic board without powering off the device.

Abstract: Configuring parameters in backup environments is described. A system outputs, via a user interface, a backup environment question. The system receives, via the user interface, an answer to the backup environment question. The system configures a backup environment parameter based on the answer to the backup environment question and based on information extracted from a corresponding backup environment.

Abstract: An eye tracking system is provided that detects the presence of problematic blobs in an image captured by the system and removes these problematic blobs by switching off illuminators. Problematic blobs may be those obscuring the pupil of the eye of the user. Each blob is detected in a first image by the use of at least one first criterion, and then an illuminator is switched off. After the illuminator is switched off, at least one second criterion is used to identify blobs in a subsequent image. This process may be repeated until the illuminator causing the problematic blob is identified.

Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.

Abstract: Images of an eye are captured at respective time instances by a camera of a head-mounted device. For each time instance, a position of a center of corneal curvature is estimated using an image captured at that time instance, a position of a pupil center is estimated using an image captured at that time instance, and a line is determined through the estimated corneal curvature center position and the estimated pupil center position. A first estimated position of a center of the eye is computed based on the lines determined for time instances in a first time period. A second estimated position of the center of the eye is computed based on the lines determined for time instances in a second time period. Relocation of the head-mounted device relative to a user's head is detected based on the first and second estimated positions of the eye center.

Abstract: Images of an eye are captured by a camera. For each of the images, gaze data is obtained and a position of a pupil center is estimated in the image. The gaze data indicates a gaze point and/or gaze direction of the eye when the image was captured. A mapping is calibrated using the obtained gaze data and the estimated positions of the pupil center. The mapping maps positions of the pupil center in images captured by the camera to gaze points at a surface, or to gaze directions. A further image of the eye is captured by the camera. A position of the pupil center is estimated in the further image. Gaze tracking is performed using the calibrated mapping and the estimated position of the pupil center in the further image. These steps may for example be performed at a HMD.