Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.

Abstract: An eye tracking system configured to: receive a plurality of right-eye-images of a right eye of a user; receive a plurality of left-eye-images of a left eye of a user, each left-eye-image corresponding to a right-eye-image in the plurality of right-eye-images; detect a pupil and determine an associated pupil-signal, for each of the plurality of right-eye-images and each of the plurality of left-eye-images; calculate a right-eye-pupil-variation of the pupil-signals for the plurality of right-eye-images and a left-eye-pupil-variation of the pupil-signals for the plurality of left-eye-images; and determine a right-eye-weighting and a left-eye-weighting based on the right-eye-pupil-variation and the left-eye-pupil-variation.

Abstract: A single-ended receiver is coupled to an input-output (I/O) pin of a command and address (CA) bus. The receiver is configurable with dual-mode I/O support to operate the CA bus in a low-swing mode and a high-swing mode. The receiver is configurable to receive a first command on the I/O pin while in the high-swing mode, initiate calibration of the slave device to operate in the low-swing mode in response to the first command, switch the slave device to operate in the low-swing mode while the CA bus remains active, and to receive a second command on the I/O pin while in the low-swing mode.

Abstract: A pharmaceutical composition containing cinacalcet or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients. A pharmaceutical composition containing cinacalcet or pharmaceutically acceptable salts thereof having a particle size distribution D90 equal to or less than 20 ?m, D50 equal to or less than 10 ?m, and D10 equal to or less than 5 ?m and one or more and binders in an amount of 0.9% w/w or less, relative to the total weight of composition, where the composition is not free of binder and that the total amount of binder does not exceed 0.9% w/w relative to the total weight of the composition.

Abstract: Described herein are systems and methods that create a capacitive link based on a rotating cylinder capacitor. A cylindrical rotor rotates around a shaft and maintains an air gap between the cylindrical rotor and the shaft and to create one or more air gap capacitors. A first subsystem, comprising a light detection and ranging components, is coupled to the rotor. A second sub-subsystem, comprising data analysis functions, is coupled to the shaft. The first subsystem and the second subsystem are coupled via capacitive links created by the air gap capacitors. The communication signaling utilized on the capacitive links may be bi-directional and differential signaling. The first subsystem and the second subsystem may comprise a LIDAR light detection and ranging system. The second subsystem may power the first subsystem via inductive coupling.

Abstract: Images of an eye are captured by a camera. For each of the images, gaze data is obtained and a position of a pupil center is estimated in the image. The gaze data indicates a gaze point and/or gaze direction of the eye when the image was captured. A mapping is calibrated using the obtained gaze data and the estimated positions of the pupil center. The mapping maps positions of the pupil center in images captured by the camera to gaze points at a surface, or to gaze directions. A further image of the eye is captured by the camera. A position of the pupil center is estimated in the further image. Gaze tracking is performed using the calibrated mapping and the estimated position of the pupil center in the further image. These steps may for example be performed at a HMD.

Abstract: A mother board with a central processing unit and two riser slots configured to cooperate with one riser card for connecting two expansion cards to the mother board. The first riser slot and the second riser slot may be connected by metal traces to the central processing unit, and the two riser slots may be spaced apart by a distance greater than 8 cm.

Abstract: An electronic device configured to be mounted in a housing of a cluster, the device comprising a rear body housing at least one mother board configured to be powered by the cluster, a front tray housing at least one electronic board having at least one socket, the front tray comprising at least one fastening member for mounting an expansion card having an edge connector and a fastening portion, the electronic board being connected to the mother board by at least one flexible cable, the front tray being mounted slidable relatively from the rear body between a close position and an open position in which the front tray is at least partially removed from the cluster housing while keeping the rear body into the cluster housing so that an expansion card can be mounted/unmounted from the electronic board without powering off the device.

Abstract: Configuring parameters in backup environments is described. A system outputs, via a user interface, a backup environment question. The system receives, via the user interface, an answer to the backup environment question. The system configures a backup environment parameter based on the answer to the backup environment question and based on information extracted from a corresponding backup environment.

Abstract: An eye tracking system is provided that detects the presence of problematic blobs in an image captured by the system and removes these problematic blobs by switching off illuminators. Problematic blobs may be those obscuring the pupil of the eye of the user. Each blob is detected in a first image by the use of at least one first criterion, and then an illuminator is switched off. After the illuminator is switched off, at least one second criterion is used to identify blobs in a subsequent image. This process may be repeated until the illuminator causing the problematic blob is identified.

Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.

Abstract: Images of an eye are captured at respective time instances by a camera of a head-mounted device. For each time instance, a position of a center of corneal curvature is estimated using an image captured at that time instance, a position of a pupil center is estimated using an image captured at that time instance, and a line is determined through the estimated corneal curvature center position and the estimated pupil center position. A first estimated position of a center of the eye is computed based on the lines determined for time instances in a first time period. A second estimated position of the center of the eye is computed based on the lines determined for time instances in a second time period. Relocation of the head-mounted device relative to a user's head is detected based on the first and second estimated positions of the eye center.

Abstract: Images of an eye are captured by a camera. For each of the images, gaze data is obtained and a position of a pupil center is estimated in the image. The gaze data indicates a gaze point and/or gaze direction of the eye when the image was captured. A mapping is calibrated using the obtained gaze data and the estimated positions of the pupil center. The mapping maps positions of the pupil center in images captured by the camera to gaze points at a surface, or to gaze directions. A further image of the eye is captured by the camera. A position of the pupil center is estimated in the further image. Gaze tracking is performed using the calibrated mapping and the estimated position of the pupil center in the further image. These steps may for example be performed at a HMD.

Abstract: A method of identifying scleral reflections in an eye tracking system is disclosed. A glint is identified in an image from an image sensor, wherein the glint is a representation in the image of a reflection of light from a cornea of the eye of the user or from a sclera of the eye of the user. A first pixel intensity of the glint is determined, a second pixel intensity of neighbor pixels of the glint is determined, and an absolute value of the difference between the first pixel intensity of the glint and the second pixel intensity of the neighbor pixels of the glint is determined. The glint is identified as a representation of a reflection from the sclera of the eye of the user on condition that the determined absolute value of the difference is below a predetermine threshold value.

Abstract: Described herein are systems and methods that create a capacitive link based on a rotating cylinder capacitor. A cylindrical rotor rotates around a shaft and maintains an air gap between the cylindrical rotor and the shaft and to create one or more air gap capacitors. A first subsystem, comprising a light detection and ranging components, is coupled to the rotor. A second sub-subsystem, comprising data analysis functions, is coupled to the shaft. The first subsystem and the second subsystem are coupled via capacitive links created by the air gap capacitors. The communication signaling utilized on the capacitive links may be bi-directional and differential signaling. The first subsystem and the second subsystem may comprise a LIDAR light detection and ranging system. The second subsystem may power the first subsystem via inductive coupling.

Abstract: The invention is related to a method for calibrating an eye tracking device within a head-mounted display (HMD) comprising the steps of acquiring with the HMD via an image sensor, at least one optical target image from an optical target, wherein the optical target contains image points in a pattern, indexing image points within the optical target image wherein the image points are indexed by, selecting a rigid region of the optical target image, assigning indices to image points within the rigid region, fitting a polynomial approximation function to at least one column and one row of the image points of the region, predicting the location of at least one image point using the fitted polynomial approximation function, assigning the predicted image point an index, inputting indexed image points into an optimization algorithm that calculates a hardware calibration of the HMD, and writing hardware calibration values calculated from the optimization algorithm to the HMD unit.

Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.

Abstract: A method of loading an executable image for a computing system includes identifying segments of at least one executable image available for loading into memory of the computing system. Each segment is associated with one or more configuration features for the computing system. At least a first segment of the at least one executable image to load into the memory of the computing system is determined, based on the first segment satisfying one or more conditions associated with the computing system. The first segment of the executable image is loaded into the memory of the computing system. At least a second segment of the at least one executable image is made available for memory re-allocation, based on the second segment not satisfying the one or more conditions associated with the computing system. Various additional and alternative aspects are described herein.

Abstract: Methods and systems for allowing software components that operate at a specific exception level (e.g., EL-3 to EL-1, etc.) to repeatedly or continuously observe or evaluate the integrity of software components operating at a lower exception level (e.g., EL-2 to EL-0) to ensure that the software components have not been corrupted or compromised (e.g., subjected to malware, cyberattacks, etc.) include a computing device that identifies, by a component operating at a higher exception level (“HEL component”), at least one of a current vector base address (VBA), an exception raising instruction (ERI) address, or a control and system register value associated with a component operating at a lower exception level (“LEL component”). The computing device may perform a responsive action in response to determining that the current VBA, the ERT address, or control and system register value do not match the corresponding reference data.

Abstract: Described herein are systems and methods that can adjust the performance of a transimpedance amplifier (TIA) in order to compensate for changing environmental and/or manufacturing conditions. In some embodiments, the changing environmental and/or manufacturing conditions may cause a reduction in beta of a bipolar junction transistor (BJT) in the TIA. A low beta may result in a high base current for the BJT causing the output voltage of the TIA to be formatted as an unusable signal output. To compensate for the low beta, the TIA generates an intermediate signal voltage, based on the base current and beta that is compared with the PN junction bias voltage on another BJT. Based on the comparison, the state of a digital state machine may be incremented, and a threshold base current is determined. This threshold base current may decide whether to compensate the operation of the TIA, or discard the chip.