Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.

Abstract: A punching device includes a base, a linkage assembly, a carrying assembly, a punch and a pressure arm. The linkage assembly includes a pair of linkage members, a rotating member, a first connecting rod, a second connecting rod and a third connecting rod. The rotating member is rotatably mounted on the supporting member, the pair of linkage members is movably mounted on the rotating member, the first, the second and the third connecting rods connects in turn. The carrying assembly is rotatably connected to the third connecting rod and movably supported by the loading member. The punch is mounted on an end of the rotating member. The pressure arm is rotatably connected to the supporting member and the pair of linkage members to drives the carrying assembly to position a workpiece and the punch to punch the workpiece.

Abstract: A system for operating multiple independent terminals of grouped, locally connected input and output devices through a single graphical user interface layer running on a computer comprising an event queue module for receiving each input command from each input device; an event handler module for receiving the input commands from the event queue module and directing input commands from specific input devices via corresponding socket/listeners of the single graphical user interface layer to corresponding ones of multiple pointers, focuses and client applications based on predetermined associations between grouped devices and respective ones of the socket/listeners; and an output module for directing output commands from each socket/listener to respective ones of the output devices based on the predetermined associations.

Abstract: A system and method are disclosed for automatically captioning an electronic demonstration using object properties captured from the operating system. In response to an action that is initiated by a demonstrator, the operating system is queried to obtain the property information for the target object to which the action is directed as well as the parent object of the target object. This property information is then used to generate explanatory captions that are displayed to a user or trainee during the playback of the electronic demonstration.

Abstract: Described herein is a context-free protocol (i.e., the COFFEE protocol) for stimulating cooperation among selfish nodes. Various embodiments have the ability to transmit a packet over the path successfully without the dependency on the information of other packets' transmissions. It is assumed that every node in the network is rational, and therefore during the packet forwarding stage, if the intermediate nodes can not clearly tell whether the packet is destined to them or not, they do not simply drop the packet. Thus, in the COFFEE protocol, by introducing several techniques, for a packet received by a node, the node thinks the packet could potentially be destined to itself and forwards the packet to find out the answer. Detailed analysis and performance evaluations have been conducted to demonstrate the effectiveness of the COFFEE protocol.

Abstract: Systems and methods for use in communication between a client and a server, via a networking device, are provided. The method may include sending a request to establish a data connection from the client to the server via the networking device, setting a data connection keep-alive interval for the data connection to a predetermined safe value, and sending a request to establish a test connection between the client and the server. The method may further include determining an efficient keep-alive interval for communication between the client and server via the networking device, using the test connection, setting the data connection keep-alive interval to the efficient keep-alive interval determined using the test connection, and uploading the efficient keep-alive interval from the client to the server in an efficient keep-alive interval notification message, for communication to other clients connected to the server.

Abstract: A method and device for detaching a user equipment (UE) are disclosed in the present invention. The UE is registered with a mobility management entity (MME) in a packet switched (PS) network and a mobile switching center (MSC) in a circuit switched (CS) network. When the UE needs to detach from the PS network, the MSC receives a Detach Request with a Detach Type indicating the detaching from the PS network only; after receiving the Detach Request, the MSC deletes the context of the PS core network entity and clears the connection between the MSC and the MME. An MME for performing UE detachment is also disclosed in the present invention. The present invention helps reduce the time delay during the subsequent handover and quickly provide users with communications services, so as to improve user's experience and meet the carriers' requirements.

Abstract: Systems, methods, and apparatus are described that employ specially designed interference patterns to build an in-band side channel without degrading the effective throughput of the main channel. A first device (100) includes a control component (130) that generates control information and an interference component (140) that transmits the control information (450) through emission of patterned interference data concurrently while other users are transmitting other data (420). A second device (300) receives the patterned interference data and the other data via a single antenna (350) and decodes the patterned interference data to extract the control data (450). The first device (100) transmits the other data (420) on a side channel (440) that resides in the same spectrum as the main channel (410) in which the other data (420) is emitted. The first device (100) encodes the interference patterns such that the control data (450) can be safely transmitted and extracted without effecting other data transmission.

Abstract: An application programming interface and related system is presented for a middleware communication space that provides asynchronous message delivery service for partially connected mobile ad hoc networks. Embodiments of the present invention use mobile devices to bridge separated islands of networks and store and propagate messages. The system and software architecture supports methods for messaging caching, transferring and routing. More specifically, embodiments provide methods and systems that extend a communication space concept into a distributed environment and combine it with the standard Web Services technologies, i.e, SOAP, and WS series protocols. The communication space provides an extension of Web Services to mobile ad hoc networks and provides asynchronous message caching, transferring and routing.

Abstract: Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.

Abstract: Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.

Abstract: The described method and system provide an efficient routing of data packets protocol in an event-driven and delay-constrained WSN (wireless sensor network) that optimizes the sleep/wake schedule of nodes to maximize the lifetime of the WSM, subject to a constraint on the source-to-sink delay. Online forwarding techniques may be used to transfer data reports from monitoring nodes to the sink. A delay-constrained and energy-efficient routing protocol (DCEER) for asynchronous WSNs may be used to maximize the lifetime of the WSN while remaining within the maximum allowable delay requirements. With DCEER, each node may maintain the historical cost of forwarding a packet from itself to the sink as its virtual coordinate, and packets are forwarded in the direction of descending coordinates. The cost-based coordinates may change dynamically with a time-varying channel or topology.

Abstract: A method and system is presented for path discovery and asynchronous message transfer in a partially connected middleware communication space comprising mobile ad hoc networks. Embodiments of the present invention use mobile devices to bridge separated islands of networks and store and propagate messages. The system and software architecture supports methods for routing, messaging caching, and transferring. More specifically, embodiments provide methods and systems that extend a communication space concept into a distributed environment and combine it with the standard Web Services technologies, i.e., SOAP, and WS series protocols. The communication space provides an extension of Web Services to mobile ad hoc networks and provides asynchronous message caching, transferring and routing.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: A method and system for signing a digital certificate in real time for accessing a service application hosted within a service provider (SP) computer system through an open application programming interface (API) platform is provided. The API platform is in communication with a memory device. The method includes receiving registration data from a developer computer device wherein the developer computer device is associated with a developer and configured to store a developer application, receiving a certificate signing request (CSR) from the developer computer device wherein the CSR includes a public key associated with the developer, verifying the registration data as being associated with the developer, signing the CSR to produce a signed certificate after verifying the registration data wherein the verifying and signing steps are performed by the SP computer system in real time, and transmitting the signed certificate and a client ID to the developer computer device.

Abstract: An Instant Messaging (IM) method and server are provided. The method includes: receiving instance login information sent by an IM client, wherein the instance login information at least includes login information of a user of the IM client and instance information of a terminal located by the IM client (101); authenticating identity of the user of the IM client, according to the login information in the instance login information (102); when the authenticating is passed, allocating an instance number for the IM client, according to the instance information in the instance login information, wherein the instance number is configured to uniquely identify the IM client (103). The server includes a receiving module (801), an authenticating module (802) and an allocating module (803). By adopting the method and server provided, multipoint login of one login account may be effectively achieved, and multiple aspects requirements of a user may be satisfied.