Abstract: A method for preparing compounds having the formula(I) by using P(3HB), wherein R is R1, R2, R3 are lower linear or branched C1-C4 alkyl, comprising the steps of: a: obtaining (3R)-3-RO—CH(CH3)CH2COOCH3 by pyrolysis of P(3HB) and protection; b: obtaining (3R)-3-RO—CH(CH3)CH2CHO by reduction of (3R)-3-RO—CH(CH3)CH2COOCH3 ; c: enolizing (3R)-3-RO—CH(CH3)CH2CHO and then reacting with chlorosulfonyl isocyanate, at last getting the final product by reduction; wherein (3R)-3-RO—CH(CH3)CH2CHO is enolized by reacting (3R)-3-RO—CH(CH3)CH2CHO with isopropenyl acetate and p-toluenesulfonic acid by heating under reflux.

Abstract: The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein.

Abstract: A method and device for detaching a user equipment (UE) are disclosed in the present invention. The UE is registered with a mobility management entity (MME) in a packet switched (PS) network and a mobile switching center (MSC) in a circuit switched (CS) network. When the UE needs to detach from the PS network, the MSC receives a Detach Request with a Detach Type indicating the detaching from the PS network only; after receiving the Detach Request, the MSC deletes the context of the PS core network entity and clears the connection between the MSC and the MME. An MME for performing UE detachment is also disclosed in the present invention. The present invention helps reduce the time delay during the subsequent handover and quickly provide users with communications services, so as to improve user's experience and meet the carriers' requirements.

Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:

Abstract: Systems and methods for use in communication between a client and a server, via a networking device, are provided. The method may include sending a request to establish a data connection from the client to the server via the networking device, setting a data connection keep-alive interval for the data connection to a predetermined safe value, and sending a request to establish a test connection between the client and the server. The method may further include determining an efficient keep-alive interval for communication between the client and server via the networking device, using the test connection, setting the data connection keep-alive interval to the efficient keep-alive interval determined using the test connection, and uploading the efficient keep-alive interval from the client to the server in an efficient keep-alive interval notification message, for communication to other clients connected to the server.

Abstract: A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.

Abstract: Described herein is a context-free protocol (i.e., the COFFEE protocol) for stimulating cooperation among selfish nodes. Various embodiments have the ability to transmit a packet over the path successfully without the dependency on the information of other packets' transmissions. It is assumed that every node in the network is rational, and therefore during the packet forwarding stage, if the intermediate nodes can not clearly tell whether the packet is destined to them or not, they do not simply drop the packet. Thus, in the COFFEE protocol, by introducing several techniques, for a packet received by a node, the node thinks the packet could potentially be destined to itself and forwards the packet to find out the answer. Detailed analysis and performance evaluations have been conducted to demonstrate the effectiveness of the COFFEE protocol.

Abstract: Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.

Abstract: Systems and methods are described for using a mobile phone to remotely control a computing device. In one implementation, a communication channel between the mobile phone and the computing device uses an overlay network, such as an instant messaging (IM) service, to exchange communication data packets. An exemplary system includes a flexible layered architecture—which allows tailoring the system for remote control of various applications using various network configurations. Based on the overlay protocol used, a transport protocol layer can provide helpful application programming interfaces (APIs). On top of the transport protocol layer, a remote control protocol defines a framework for packet exchange of extensible commands, customizable for remote control of diverse applications. Use of paired-key encryption, IM accounts, and buddy lists ensure that communications between mobile phone and remote computer are secure.

Abstract: Systems and methods are described for using a mobile phone to control a computing device. In one implementation, a communication protocol stack is established that includes a wireless layer, such as a BLUETOOTH wireless protocol (IEEE Standard 802.15.1) stack, a communication layer that multiplexes the wireless layer into virtual channels, and an application adaptation layer by which the mobile phone controls and previews content from each of multiple applications on the computing device. The communication protocol stack dynamically maps mobile phone keys to computer keyboard messages for controlling the applications on the computing device. A data packet structure is established for communications between the mobile phone and the computing device via the communication protocol stack.

Abstract: A middle layer network protocol enhancement, virtual connectivity (VC) makes the network attachment point changes of local and remote peers transparent to applications that use network services. A virtual connectivity module local to each peer translates communication connection parameters from apparent to real and vice versa, as well as sending and receiving secure connection updates directly to and from peers. Unlike Mobile IP, no routing infrastructure modifications are required. A subscribe-notify service provides connection update notifications when direct peer-to-peer connection updates are not possible, for example, when two communicating peers move simultaneously or when the moving peer is communicating with a peer behind network address translation (NAT). Methods for detecting these conditions are disclosed, as is a virtual connectivity protocol and virtual connectivity module architecture.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: A network device for accelerating internet small computer systems interface (iSCSI) packet processing is described, which includes a host and a network card. The host includes an online command descriptor block queue, an iSCSI host manager, and an SCSI module. SCSI commands in a CDB are processed through these modules. The network card includes an LLP module and a microprocessor. Through a protocol data unit descriptor, a PDU generator and an iSCSI network card manager in the microprocessor, protocol data units in network packets can be resolved in advance, so that the host can concentrate on executing SCSI commands, thereby accelerating the network packet processing efficiency of the network device.

Abstract: Wireless network interference is mitigated with client devices having wireless network interference mitigation logic and/or utilizing a usable bandwidth channel quality metric. In a described example implementation, a client device includes wireless network interference mitigation logic that monitors at least one channel condition of a wireless network and participates in a wireless network interference mitigation procedure based on the at least one channel condition. In another described example implementation, a usable bandwidth of a wireless channel is ascertained with respect to a native network, the usable bandwidth reflecting a difference between (i) a total channel capacity of the wireless channel and (ii) a portion of the total channel capacity that is consumed by wireless communications of one or more foreign networks. By way of example only, the at least one channel condition may be usable bandwidth. The wireless network interference mitigation logic may also be employed in non-client devices.

Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

Abstract: A peer-to-peer (P2P) probing/network quality of service (QoS) analysis system utilizes a UDP-based probing tool for determining latency, bandwidth, and packet loss ratio between peers in a network. The probing tool enables network QoS probing between peers that connect through a network address translator. The list of peers to probe is provided by a connection server based on prior probe results and an estimate of the network condition. The list includes those peers which are predicted to have the best QoS with the requesting peer. Once the list is obtained, the requesting peer probes the actual QoS to each peer on the list, and returns these results to the connection server. P2P probing in parallel using a modified packet-pair scheme is utilized. If anomalous results are obtained, a hop-by-hop probing scheme is utilized to determine the QoS of each link. In such a scheme, differential destination measurement is utilized.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: A method and system for encoding a mark-up language document is provided, in which, the structure of the mark-up language document is condensed by removing those parts of the structure that are fixed, and by expressing the variable parts of the structure in terms of whether or how often they occur. A template that specifies which parts of the structure are fixed and which parts are variable may be provided to both the device that is transmitting the mark-up language document and the device that is receiving the mark-up language document.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.