Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A system for content (e.g., streaming media) is presented comprising a server, to provide media content on request through a wireline network, coupled to a wireless host through a network gateway. The network gateway establishes a communication channel from the server to the wireless host through both a wireline network and a wireless network, wherein the communication channel includes a transport layer protocol with control parameters for network elements of each of the wireline network and the wireless network. This abstract itself is not intended to limit the scope of this patent. The scope of the present invention is pointed out in the appending claims.

Abstract: A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A resource allocation of multiple compressed AV streams delivered over the Internet is disclosed that achieves end-to-end optimal quality through a multimedia streaming TCP-friendly transport (MSTFP) protocol that adaptively estimates the network bandwidth while smoothing the sending rate. Resources allocated dynamically according to a media encoding distortion and network degradation algorithm. A scheme is also disclosed for dynamically estimating the available network bandwidth for streaming of objects, such as MPEG4 multiple video objects, in conjunction with the MSTFP protocol. The scheme can account for packet-loss rates to minimize end-to-end distortion for media delivery.

Abstract: A network emulator provides both per-connection and non-connection-based emulation. The emulator includes a host computer, and a kernel-mode emulator driver and user-mode application component running on the host computer. The application component supplies configuration parameters to the driver. The driver includes a packet filter list that filters a captured packet, a virtual network link that receives the packet from the packet filter list, a link group list that applies an emulation procedure to the packet, a timer management component that manages a timer associated with the emulation procedure, and a packet dispatcher component that sends out the packet. A connection pool component facilitates per-connection emulation.

Abstract: A system and method for improved vertical handoff between different types of wireless network. Network allocation vector occupation and packet collision probability are used as quality of service measures, enabling vertical handoffs to be delayed until actually beneficial to quality of service. Improved wireless network cell boundary detection in vertical handoff scenarios is achieved with a Fourier-based technique in conjunction with an adaptively determined minimum operating signal strength threshold. Improved wireless network cell boundary detection enables vertical handoffs from high quality of service networks to be delayed as long as possible. Together, practical wireless network quality of service measures and improved detection of wireless network cell boundaries in vertical handoff scenarios reduce the rate of unnecessary vertical handoff resulting in higher overall quality of service experienced by a mobile computing device roaming between wireless network types.

Abstract: A fuel-fired water heater has a single pass condensing-type heat exchanger disposed within its water storage tank portion. The heat exchanger includes a primary non-condensing portion defined by a combustion chamber positioned in an upper interior portion of the tank and having a spaced series of vertical tubes depending therefrom. A secondary condensing portion of the heat exchanger is defined by a plenum having a top side connected to the bottom ends of the vertical tubes, and a bottom side from which a downwardly coiled flue tube depends. A fuel burner generates hot combustion gases that are sequentially flowed into the combustion chamber and then downwardly through the balance of the heat exchanger in a single pass.

Abstract: A method and system for emulating a network bandwidth condition includes maintaining a queue for holding packets that are received, maintaining a virtual time that is updated whenever a packet timer is scheduled, and, for a selected packet waiting in the queue, calculating a timer expiration time based on the virtual time. A bandwidth emulation module is controlled by an emulator link that comprises a virtual network link to which a first computer is connected. One or more computers may be linked to the first computer.

Abstract: A spurious timeout (STO) response allows a sending device to conservatively adjust congestion state parameters and maintain the packet flow, after detection of the STO. Since occurrence of an STO may be accompanied by data loss, the STO response couples the spurious timeout and the loss event by maintaining a value of previously available bandwidth and increasing a limit that a sending host can send based on a pattern of returned acknowledgements. In particular, the limit is increased by the maximum size of a data segment that the sending host can send each time an acknowledgement is received from the receiving host indicating a successful transmission of a data packet. Thus, a positive data flow may be maintained conservatively while avoiding further packet losses and an unnecessary re-transmission of data packets that may have been successfully received by the receiving host.

Abstract: A method for detecting a spurious timeout in a TCP network which can be used to avoid unnecessarily triggering the TCP rate adaptation is disclosed. Upon detection of a timeout on a given packet, a shortened packet version of the possibly lost packet is retransmitted. The retransmitted packet is at least one byte shorter than the original packet. The node receiving this retransmitted packet will acknowledge the receipt of the packet as specified in the TCP protocol. The acknowledgment will contain the sequence number of the lowest byte the receiving node has not yet received. Because the retransmitted packet is shorter than the original packet, the sequence number of this as yet not received byte will be less than or equal to the last byte of the original packet if the original packet was not received indicating a valid timeout.

Abstract: Emulating a packet reorder condition in a network includes maintaining a counter variable to count packets sent out since the most recent reordered packet. When a new packet arrives, if the counter variable is less than or equal to zero, a current packet lag value is determined. If the current packet lag value is not equal to zero, the new packet is delayed before being sent out in accordance with the lag value, and the counter is updated with the lag value. Otherwise, the new packet is sent out without delay and the counter is decreased by one. The current packet lag value is computed based on supplied configuration parameters. Delaying the new packet includes applying a latency to the packet, the latency comprising a time cost to transmit the packet multiplied by the current packet lag value.

Abstract: The present technique for automating service discovery and the set-up of a wireless network improves a user's experience when setting-up the wireless network and using one or more services. The technique includes automatic neighbor/service discovery using special beacons transmitted from wireless devices. Each special beacon identifies the wireless device (i.e., host) that transmitted the beacon along with the services provided by the device. For each special beacon that is received, a corresponding host name and the service provided by it are displayed in a graphical user interface. A user may select one or more of the host names and initiate a transmission of a network set-up and service request. The network set-up and service request identifies the selected host names and invites each selected host name to become a member of a wireless network. After the network has been set up, the service may be invoked automatically.

Abstract: A fuel-fired water heater has a three-pass condensing type heat exchanger disposed within its tank and having a central vertical first pass flue pipe separated into upper and lower portions by an internal dividing structure. Respectively coupled to the upper and lower first pass flue pipe portions are circumferentially spaced series of vertical second and third pass flue pipes which circumscribe the central flue pipe within the tank. During firing of the water heater, combustion gases from a power burner are sequentially forced downwardly through the upper portion of the first pass flue pipe, upwardly through the second pass flue pipes to an upper plenum external to the tank, and then downwardly through the third pass flue pipes and the lower central pipe portion into a bottom plenum external to the tank for discharge from the water heater.

Abstract: A source encoder encodes audio signals into increasing quality layers defined in bit planes. Each bit plane has a data unit that includes a beginning partition having one or more contiguous refinement bits, a second partition having one or more contiguous coded significance bits, a third partition having one or more contiguous sign boundary mark bits, and a fourth partition having one or more contiguous coded sign bits. A channel encoder encodes the bit planes into respective columns containing multiple rows. Unequal error protection coding is provided according to the quality of each layer such that each row has row and column channel protection codes for the respective row and column that correspond to the respective quality layer. For the corresponding row and column, each row contains the row channel protection codes and either the compressed audio data from the respective layer or the column channel protection codes.

Abstract: A topical composition and a method for improving skin characteristics are described. The topical composition comprises a mixture physical scatterers having a neat particle size from about 5 to less than about 100 nm and greater than about 300 nm to about 2 microns. The topical composition of the present invention, when applied, results in desirable skin lightening free of reddish and blotchy characteristics such that a 75 micron thick film of the same yields a red intensity (a) of less than ?1.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

Abstract: A resource allocation of multiple compressed AV streams delivered over the Internet is disclosed that achieves end-to-end optimal quality through a multimedia streaming TCP-friendly transport (MSTFP) protocol that adaptively estimates the network bandwidth while smoothing the sending rate. Resources allocated dynamically according to a media encoding distortion and network degradation algorithm. A scheme is also disclosed for dynamically estimating the available network bandwidth for streaming of objects, such as MPEG-4 multiple video objects, in conjunction with the MSTFP protocol. The scheme can account for packet-loss rates to minimize end-to-end distortion for media delivery.

Abstract: A fuel-fired commercial water heater has upper and lower communicated tank portions which are separated by a plenum forming a vertically intermediate portion of a dual pass condensing type heat exchanger. A lower portion of the heat exchanger is defined by a series of vertical flue tubes extending through the lower tank and intercommunicating the plenum with a combustion chamber disposed beneath the lower tank and having a fuel burner with a discharge portion communicated therewith. An upper portion of the heat exchanger is defined by a vertical flue pipe, disposed in the upper tank, that extends upwardly from the plenum and then coils downwardly around itself and horizontally exits the upper tank. During firing of water heater the burner flows flue gases sequentially through the lower tank flue tubes, the plenum, and the upper tank coiled flue pipe structure.