Abstract: The present invention relates to the field of pharmaceutical and chemical engineering, and specifically relates to a weakly acidic microenvironment-sensitive aptamer for tumors, a triptolide conjugate. The conjugate is formed by conjugation between the 14-position hydroxyl group of triptolide and the aptamer via an acetal ester linking bond, which is an acid-sensitive linking bond with a cleavage condition of (pH=3.5-6.5), which is much less pH-sensitive and is more likely to cleave under the tumor microenvironment. Based on the characteristics of the aptamer targeting the highly expressed proteins on the membrane surface of tumor cells, the conjugate delivered triptolide targeted to tumor cells and mediated endocytosis to reach the lysosome; based on the characteristics of the acidic environment of lysosomes, the acetal ester linking bond released intact triptolide in the lysosomal acidic environment, targeting and killing of tumor cells.

Abstract: The present invention relates to a method for producing crystallized glass, including: (a1) melting a glass raw material to obtain molten glass; (a2) molding the molten glass into a predetermined shape by a molding unit to obtain a glass molded body; (a3) slowly cooling the glass molded body to obtain a raw glass plate containing at least one of a crystal nucleus and a separated phase; and (a4) heat-treating the raw glass plate containing the at least one of the crystal nucleus and the separated phase to cause crystal growth so as to obtain the crystallized glass.

Abstract: The present disclosure provides a fire retardant wood, a preparation method thereof, and a use of metal halide. The preparation method of fire retardant wood includes: impregnating a wood with a salt solution. By injecting low-cost metal halide into the interior of wood, the present disclosure obtains wood with natural color and texture and high flame retardant ability, which is very suitable for use in decorative environment and is expected to be applied in many fields such as furniture, architecture, shipbuilding and ancient wood preservation.

Abstract: Aspects of the disclosure provide methods and apparatuses for storing data. In some examples, an information processing apparatus that includes processing circuitry is provided. The processing circuitry is configured to receive data and determine a target blockchain based on an attribute associated with the data and blockchain correspondence information. The blockchain correspondence information indicates attributes associated with a plurality of blockchains. Further, the processing circuitry is configured to store a first block that is generated based on the received data in the target blockchain.

Abstract: Methods for detecting and extracting plastic contaminants within a water sample, which involve introducing the water sample to a hydrophobic deep eutectic solvent, are provided.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a first user equipment (UE) may identify an active state of a first sidelink (SL) discontinuous reception (DRX) cycle of the first UE and an active state of a second SL DRX cycle of a second UE. The first UE may transmit, to the second UE based at least in part on an overlap between the active state of the first SL DRX cycle and the active state of the second SL DRX cycle, an indication associated with adjusting the first SL DRX cycle or the second SL DRX cycle. Numerous other aspects are described.

Abstract: Methods, systems, and apparatuses are described herein for beamforming based initial access, beam management, and beam based mobility designs for NR systems. Issues are identified and addressed related to, for example, initial access, control channel design, eMBB and URLLC mixing, and beam training.

Abstract: The present disclosure provides a method and device for intelligent control of heating furnace combustion based on a big data cloud platform, which relates to the technical field of artificial intelligence control. The method includes: construction of big data cloud platform based on production and operation parameters of the heating furnace; identification of key factors in the production process of the heating furnace by using big data mining technology; independent deployment of traditional heating furnace combustion control systems based on the mechanism model; and integration of cloud platform big data expert knowledge base and the heating furnace combustion intelligent control system.

Abstract: An early warning method for safety production risk of tailings pond based on risk ranking is provided. The early warning method includes: monitoring and collecting internal basic data of a tailings pond in real-time, and performing a basic monitoring and a basic early warning; collecting geographical location data, meteorological data, and historical geological disaster data of an area where the tailings pond is located; performing risk ranking on a safety production risk of the tailings pond, thereby obtaining a risk level of the tailings pond; and collecting case data of global tailings pond accidents and hazard degree data thereof, acquiring accident solution strategies for the global tailings pond accidents, performing management and monitoring on the tailings pond, setting parameters in a process of the basic monitoring, and performing a ranked early warning on the safety production risk of the tailings pond based on the risk level.

Abstract: This disclosure relates to antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody. Provided herein are compositions comprising such ADCs, as well as methods of making and using the same.

Abstract: The present disclosure relates to a computer-executable method for assisting a user in caring for a plant. The method comprises: identifying the species and growth stage of a plant in a picture by a plant recognition model, and generating a caring plan for the plant based on the species and the growth stage; recognizing a health state of the plant in the picture by a health detection model, and adjusting the caring plan based on the health state; and according to the adjusted caring plan, outputting a prompt regarding the execution of a corresponding caring task at a predetermined time.

Abstract: The present disclosure provides a non-contact fatigue detection system and method based on rPPG. The system and method adopt multi-thread synchronous communication for real-time acquisition and processing of rPPG signal, enabling fatigue status detection. In this setup, the first thread handles real-time rPPG data capture, storage and concatenation, while the second thread conducts real-time analysis and fatigue detection of rPPG data. Through a combination of skin detection and LUV color space conversion, rPPG raw signal extraction is achieved, effectively eliminating interference from internal and external environmental facial noise; Subsequently, an adaptive multi-stage filtering process enhances the signal-to-noise ratio, and a multi-dimensional fusion CNN model ensures accurate detection of respiration and heart rate.

Abstract: A system for maintaining a meta-database including meta-data representing decentralized data from source databases, which cause inefficient selection of modeling data and/or variables. Each of source and meta-data interfaces communicate with the respective database(s). A key variable repository module operably couples the databases and includes an AI program with a scanner algorithm and a profiler algorithm. The scanner algorithm receives the source data from the source interface, compresses the data, and synchronizes the data with the meta-data using the meta-database interface. The profiler algorithm receives the meta-data from the meta-database interface, generates granular data types for the meta-data, determines variables indicative of the meta-data, generates variable probability distributions, produces variable associations, and modifies the meta-database to include the probability distributions and associations using the meta-data interface.

Abstract: Methods, systems, and devices for access control configurations for inter-processor communications are described to support reconfiguration of a dynamic access control configuration at a device. The configuration may support additional configuration fields that may be added to existing access control rules of the device. A processor of the device may request creation of a new shared memory resource, using a subregion of an existing memory resource, where the additional fields may indicate a parent memory resource for the new memory resource. The additional fields may also include a value which may indicate a processor which has write permission for a respective memory region of the shared memory, where other processors of the device may be prevented from writing to the memory region. The additional fields may further indicate a chain of delegation, or a history, of which processors have been assigned the exclusive write permission for the respective memory region.

Abstract: Disclosed is a method for reducing pressure and increasing injection by continuous operation system of biological acid acidification and nano coating, specifically including composition and preparation method of biological acidizing agent and nano coating agent. The method for reducing pressure and increasing injection by continuous operation system of biological acid acidification and nano coating of the present disclosure is able to effectively dredge the stratum water flow channel, reduce the water flow resistance, and achieve the effect of high-efficiency pressure reduction and injection increase of the water injection well.

Abstract: Multiple mobility sets are maintained for nodes of radio networks. The sets comprise information such as: transmit and receive point identities; cell identities; beam identities; frequency channels; channel bandwidth; and black lists. The sets may be defined at different levels, such as network and physical (PHY) level. A network mobility set, e.g., a new-radio (NR) mobility set may, be determined by the gNB, the cell, the UE, or another device. Multiple radio access network nodes and UEs may exchange mobility set information to achieve a distributed mobility solution. A UE may monitor its orientation relative to a TRP, e.g., via use of an onboard MEMS gyroscope, and alter its beamforming parameters in response to changes in orientation and/or changes in TRP connection strength. Cell selection and reselection for beam based networks may use Single Frequency Network (SFN) broadcast of initial access signals without beam sweeping.

Abstract: Various processes for efficiently and effectively managing huge pages include a process for optimizing memory deduplication of huge pages, optimizing the promotion of one or more base pages to one or more huge pages and optimizing memory compaction of a memory space associated with a huge page.

Abstract: An information handling system may include at least one processor and a memory. The information handling system may be configured to: execute an application comprising a plurality of microservices on the at least one processor, wherein the application is configured to service external requests by executing a plurality of application programming interface (API) calls among the plurality of microservices; and for each API call: determine a span ID associated with such API call; determine a trace ID associated with a particular external request that is associated with such API call; and log the span ID and the trace ID.

Abstract: The present invention relates to a preparation and purification method for cationic quaternary ammonium salt of sodium hyaluronate in homogeneous medium. By adding a homogeneous solvent and a sodium hyaluronate solid to a vessel, heating the vessel until the contents are dissolved to form a homogeneous system, adding an aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (GTA) to the homogeneous system, then adding a base catalyst, and stirring at a preset temperature to carry out a graft reaction, a graft product is obtained wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate. By using the method, a graft product wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate is obtained. Addition of salts is avoided during the reaction, a grafting yield up to 0.69 is obtained, and coagulation occurred to the product is effectively solved.

Abstract: Resource optimized forwarding of classified requests to different instances of a microservice is provided. The process includes obtaining classified requests to a microservice. The classified requests are classified based on different microservice resource consumption types. Further, the method includes forwarding the classified requests to instances of the microservice with different assigned resource configurations. The forwarding is based on the different microservice resource consumption types of the classified requests.