Abstract: The present disclosure provides a compound represented by formula (I), or a salt or a stereoisomer thereof. The compound is capable of effectively inhibiting germination of Clostridium difficile spores with a significant bacteriostatic activity. The compound has an excellent prospect for use in preparation of a drug for preventing and/or treating a C. difficile-caused infectious disease, recurrence of the C. difficile-caused infectious disease, or a complication of the C. difficile-caused infectious disease.

Abstract: A high-power electro-optic modulator (EOM) is formed to use specialized electrodes of a material selected to have a CTE that matches the CTE of the modulator's crystal. Providing CTE matching reduces the presence of stress-induced birefringence, which is known to cause unwanted modulation of the propagating optical signal. The specialized electrodes are preferably formed of a CuW metal matrix composite having a W/Cu ratio selected to create the matching CTE value. Advantageously, the CuW-based electrodes also exhibit a thermal conductivity about an order of magnitude greater than conventional electrode material (brass, Kovar) and thus provide additional thermal stability to the EOM's performance.

Abstract: A narrow linewidth mid infrared laser, including a pumping laser diode with a fast-axis compressor and a pumping wavelength ?o; and an optical resonator arranged to receive the pumping wavelength ?o, the optical resonator including a laser crystal with a lasing wavelength ?p, a dichroic mirror, and a nonlinear crystal to generate an idler wavelength ?i.

Abstract: In a method of forming a diamond film, substrate, or window, a substrate is provided and the diamond film, substrate, or window is CVD grown on a surface of the substrate. The grown diamond film, substrate, or window has a thickness between 150-999 microns and an aspect ratio?100, wherein the aspect ratio is a ratio of a largest dimension of the diamond film, substrate or window divided by a thickness of the diamond film. The substrate can optionally be removed or separated from the grown diamond film, substrate, or window.

Abstract: An eye-tracking apparatus. At least one light source and a plurality of sensors are arranged at a periphery of a first surface of at least one lens. A frame is employed to hold the at least one lens. A processor coupled to the at least one light source and the plurality of sensors is configured to control the at least one light source to emit light towards the user's eye, control the plurality of sensors to sense reflections of the light off a surface of the user's eye, and process sensor data pertaining to the sensed reflections to determine a gaze direction of the user's eye.

Abstract: The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract: In a method of preparing an immobilized selenium system or body, a selenium-carbon-oxygen mixture is formed. The mixture is then heated to a temperature above the melting temperature of selenium and the heated mixture is then cooled to ambient or room temperature, thereby forming the immobilized selenium system or body.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.

Abstract: A production method of a vehicle support device including: making a symmetrical thread structure by pressing on both sides of a round steel, to obtain a twin-screw rod; making a through hole in the steel block which the twin-screw rod can go through, and making internal threads in the through hole that match with the twin-screw rod by stamping to obtain an adjusting block; rotating the two adjusting blocks respectively along the ends of the twin-screw rod to the middle of the same so that the two adjusting blocks are mounted onto both sides of the twin-screw rod; making a movable frame, and fixing it with two adjusting blocks; and making a spanner and fixing it to one end or the middle of the twin-screw rod.

Abstract: The application relates to a compound of Formula (I?) or (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of Formula (I?) or (I), and a method of treating or preventing a disease in which SSAO plays a role.

Abstract: A computing system can implement pick-up location optimization by receiving trip requests and location data from computing devices of users and determining a specified region in which each requesting user is located. Each region can be associated with a plurality of eligible pickup locations. The computing system can score each of a plurality of eligible pickup locations based, at least in part, on (i) ETAs of vehicles to the pickup locations, and (ii) an amount of reduced time for utilizing each pickup location as opposed to the current location of the requesting user or a pick-up location specified by the requesting user. Based on the scoring, the computing system may then select (i) a trip pickup location to initiate the trip request, and (ii) a selected vehicle from the set of candidate vehicles to service the trip request.

Abstract: A damage identification method based on cable force tests of a cable system and test error self-adaptive analysis is proposed to measure cable forces in prestressed steel structures and find out possible damage positions of the cable system. The method includes placing a laser velocimeter; measuring the vibration speed history data of the measuring point P on the cable by the laser velocimeter; calculating the cable force; calculating all the cable forces of the cable system through the same procedure; analyzing error between cables and finding out the possible damage of the cable or of the tie rod connected to the cable. The dynamic response characteristics of both in-plane and out-of-plane of a cable can be obtained through the method of the present invention. The self-verified more accurate results can be obtained, and the damage in a cable system can be determined according to error self-adaptive analysis.

Abstract: The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract: A record of authorization including user information is received and appended to a blockchain. The record of authorization authorizes access by a third-party application to the user information for an access duration. The user information is encrypted by a group key and access duration is based on a change to the group key. The group key comprises a public/private key pair, and the access duration is implemented by an authorization group of nodes having the group key. The group key corresponds to either a valid group key at or near the start of the access duration, that enables decryption of a message in the record of authorization that includes the user information, or an incompatible group key at or after the end of the access duration, that does not enable decryption of the message in the record of authorization that includes the user information.

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Abstract: An immobilized selenium body, made from carbon and selenium and optionally sulfur, makes selenium more stable, requiring a higher temperature or an increase in kinetic energy for selenium to escape from the immobilized selenium body and enter a gas system, as compared to selenium alone Immobilized selenium localized in a carbon skeleton can be utilized in a rechargeable battery Immobilization of the selenium can impart compression stress on both the carbon skeleton and the selenium. Such compression stress enhances the electrical conductivity in the carbon skeleton and among the selenium particles and creates an interface for electrons to be delivered and or harvested in use of the battery. A rechargeable battery made from immobilized selenium can be charged or discharged at a faster rate over conventional batteries and can demonstrate excellent cycling stability.

Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

Abstract: The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I? and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

Abstract: The present invention discloses a UWB base station and a positioning method therefor. The UWB base station includes four antennae, obverse sides of the four antennae respectively face four azimuth directions, by which 360° may be uniformly divided, on a horizontal section. Azimuth directions faced by the first and the third antenna differ by 180°, and azimuth directions faced by the second and the fourth antenna differ by 180°. The station further includes a single-pole and a double-pole double-throw switch and a UWB module, the UWB module includes a transmitting end, a first and a second receiving end; first receiving end is respectively connected to the second and fourth antenna through single-pole double-throw switch; and transmitting end and second receiving end are respectively connected to the first and third antenna through double-pole double-throw switch. According to the invention, 360° omnidirectional positioning can be achieved, and the positioning precision is high.