Abstract: The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof, of the formula (I) which possess BTK inhibitory activity and are accordingly useful in therapy and in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments for use in a therapeutic effect in a warm-blooded animal such as man.

Abstract: Various embodiments of the teachings herein include a mixer disposed in a fuel gas combustion system and mixing air and fuel gas to form flammable mixed gases. The mixer may include: a Venturi tube having an air inlet, a fuel gas inlet, a gas mixture outlet, a central axis direction, and a throat positioned between the air inlet and the gas mixture outlet in the central axis direction, wherein the fuel gas inlet is disposed at the throat; and an adjustment component disposed in the Venturi tube downstream of the throat, the adjustment component drivable to move towards or away from the throat in the central axis direction, thereby changing a flow area of gas in the Venturi tube. The adjustment component comprises a conical valve plug with a conical outer surface thereof at a side facing towards the throat and fitting an inner surface of the Venturi tube.

Abstract: This present invention relates to a drug carrier comprising a polymer of ?-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal, and a method for preparing the same. It can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.

Abstract: A force sensing probe (100) for sensing snap-in and/or pull-off force of a liquid droplet (111) brought into and/or separated from contact with a hydrophobic sample surface (151), respectively, comprises: a sensing tip (101); a sensor element (102) connected to the sensing tip, capable of sensing sub-micronewton forces acting on the sensing tip in a measurement direction; and a droplet holding plate (104) having a first main surface (105) and a hydrophilic second main surface (106) connected via a peripheral edge surface (107), and being attached via the first main surface to the sensing tip (101) perpendicularly relative to the measurement direction for receiving and holding a liquid droplet (111) as attached to the second main surface; the droplet holding plate comprising an electrically conductive surface layer (115), the first and the second main surfaces and the peripheral edge surface being defined by the surface layer.

Abstract: A multifunctional shower support arm is disclosed. The support arm includes a handle, a locking cover, a switching valve, a four-way joint and a support arm. An installation cavity is provided in the four-way joint, and the switching valve is installed in the installation cavity. A head of that switching valve is connected with the handle, and the four-way joint is connected with a first screw by welding. The four-way joint is connected with the supporting arm through the cooperation of the first screw and the first nut. The end of the supporting arm is connected with the top spray. The inlet water channel, the first outlet water channel and the second outlet water channel are arranged inside the four-way joint. The water inlet channel, the first water outlet channel and the second water outlet channel are respectively communicated with the installation cavity.

Abstract: This present invention relates to a drug carrier comprising a polymer of ?-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal, and a method for preparing the same. It can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.

Abstract: An online system for determining advertisements for retrieval is disclosed. The online system may assign a unique category path associated with a hierarchy of advertisement categories to a plurality of advertisements accessible by the online system to determine advertisement information features. The online system may determine a plurality of types of user engagements associated with prior user interactions by a user with one or more of the advertisements or types of advertisements associated with the advertisements to determine a set of user engagement features. The online system may select user engagement features, from the set, based on determined user engagement results to obtain user related features. The online system may associate the user related features with an assigned unique category path, associated with the ad information features, to generate inverted index features. The online system may apply the inverted index features as inputs to a neural network.

Abstract: This present invention relates to a polymer of ?-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal. The polymer comprises a ?-glutamyl transpeptidase-responsive element represented by Formula (I). When the polymer is used as drug carrier for anticancer drug, it can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.

Abstract: An improved electric circuit structure for short circuit protection is applicable to examining a device under test, comprising a circuit breaking element, a thermistor, a filtering and rectifying module and a capacitor. A first end of the circuit breaking element is connected to a power source. The filtering and rectifying module is connected to a second end of the circuit breaking element, a ground, a first end of the thermistor and a first end of the capacitor. A second end of the capacitor is connected to a second end of the thermistor. The capacitor is connected in parallel with the device under test. The circuit breaking element disclosed in the present invention is a ceramic tube fuse and forms an open circuit when the device under test forms a short circuit. Meanwhile, the ceramic tube fuse withstands voltage between its first and second end without generating any physical damage.

Abstract: The disclosure generally relates to a method of creating patterned metallic circuits (e.g., silver circuits) on a substrate (e.g., a ceramic substrate). A porous metal interlayer (e.g., porous nickel) is applied to the substrate to improve wetting and adhesion of the patterned metal circuit material to the substrate. The substrate is heated to a temperature sufficient to melt the patterned metal circuit material but not the porous metal interlayer. Spreading of molten metal circuit material on the substrate is controlled by the porous metal interlayer, which can itself be patterned, such as having a defined circuit pattern. Thick-film silver or other metal circuits can be custom designed in complicated shapes for high temperature/high power applications. The materials designated for the circuit design allows for a low-cost method of generating silver circuits other metal circuits on a ceramic substrate.

Abstract: Embodiments of the present application provide a computer-implemented connection control method based on a QUIC protocol, comprising: receiving a QUIC connection request from a peer endpoint; analyzing the QUIC connection request and obtaining identification information of the peer endpoint; retrieving target historical information of the peer endpoint based on the identification information; adjusting a transport parameter based on the target historical information; establishing a QUIC connection with the peer endpoint based on an adjusted transport parameter; and controlling a connection state of the QUIC connection based on the adjusted transport parameter.

Abstract: The present disclosure provides a method of processing data based on QUIC protocol stack, the method including: obtaining a connection identifier of a data packet; determining a server program used for processing the data packet, wherein the server program comprises a plurality of worker threads, wherein QUIC protocol stacks run in the plurality of worker threads; determining a corresponding worker thread from the multiple worker threads based on the connection identifier; and distributing the data packet to the corresponding worker thread to make the QUIC protocol stack on the corresponding worker thread process the data packet. The disclosure further provides a system, a computing device and a computer-readable storage medium of processing data based on QUIC protocol stack.

Abstract: The disclosure generally relates to a method of creating patterned metallic circuits (e.g., silver circuits) on a substrate (e.g., a ceramic substrate). A porous metal interlayer (e.g., porous nickel) is applied to the substrate to improve wetting and adhesion of the patterned metal circuit material to the substrate. The substrate is heated to a temperature sufficient to melt the patterned metal circuit material but not the porous metal interlayer. Spreading of molten metal circuit material on the substrate is controlled by the porous metal interlayer, which can itself be patterned, such as having a defined circuit pattern. Thick-film silver or other metal circuits can be custom designed in complicated shapes for high temperature/high power applications. The materials designated for the circuit design allows for a low-cost method of generating silver circuits other metal circuits on a ceramic substrate.

Abstract: This invention provides a reversible hydrogen loading and discharging system and a reversible method for loading and discharging hydrogen. The system and the methods of this invention comprise ethylene glycol as a liquid organic hydrogen carrier and at least one transition metal. By reacting ethylene glycol with at least one transition metal; at least one hydrogen molecule and at least one oligoester of ethylene glycol are formed (hydrogen releasing)?, and by reacting at least one oligoester of ethylene glycol with at least one transition metal and at least one hydrogen molecule, at least one ethylene glycol is formed (hydrogen loading).

Abstract: The disclosure relates to a brazing method for joining substrates, in particular where one of the substrates is difficult to wet with molten braze material. The method includes formation of a porous metal layer on a first substrate to assist wetting of the first substrate with a molten braze metal, which in turn permits joining of the first substrate with a second substrate via a braze metal later in an assembled brazed joint. Ceramic substrates can be particularly difficult to wet with molten braze metals, and the disclosed method can be used to join a ceramic substrate to another substrate. The brazed joint can be incorporated into a solid-oxide fuel cell, for example as a stack component thereof, in particular when the first substrate is a ceramic substrate and the joined substrate is a metallic substrate.

Abstract: A carbon nanotube composite vector having a synergistic effect of photothermal therapy and gene therapy, a preparation method therefor, and an application thereof. The vector includes a vector moiety and a gene, and the vector moiety includes carbon nanotubes, a peptide lipid, and/or an additive. A modifier is immobilized on the carbon nanotubes by a self-assembly process to prepare the composite vector that can carry and transfer the gene. The composite vector overcomes the problems that pure carbon nanotubes have poor water solubility, low biocompatibility, and poor gene carrying and transfer efficiency; moreover, the composite vector has higher photothermal conversion performances and gene transfer efficiency, reduces cytotoxicity of carbon nanotubes, and alleviates the problem of localized accumulation of carbon nanotubes. The synergistic effect of photothermal therapy and gene therapy is applied to resolve the problem in tumor treatment that the efficacy of a single treatment method is poor.

Abstract: A spiral ultrasonic tomography imaging method and system are provided. The method is to use synchronous rotation of an ultrasonic probe or cyclic switching of emission array elements in the ultrasonic probe under the premise of a uniform displacement of the ultrasonic probe along the Z axis, so that the change trajectory of the positions of emission array elements over time in a three-dimensional space at each ultrasonic emission time is distributed along a spiral line or a curve. During the process of the uniform displacement of the ultrasonic probe along the Z axis, the ultrasonic probe emits ultrasonic waves and receives and collects echo data. The collected echo data is stored and post-processed to realize ultrasonic tomography imaging of an object. The spiral ultrasonic tomography three-dimensional scanning method and the corresponding system realize rapid continuous uninterrupted data acquisition to ensure that higher spatial resolution in the Z-axis direction.

Abstract: An improved electric circuit structure for short circuit protection is applicable to examining a device under test, comprising a circuit breaking element, a thermistor, a filtering and rectifying module and a capacitor. A first end of the circuit breaking element is connected to a power source. The filtering and rectifying module is connected to a second end of the circuit breaking element, a ground, a first end of the thermistor and a first end of the capacitor. A second end of the capacitor is connected to a second end of the thermistor. The capacitor is connected in parallel with the device under test. The circuit breaking element disclosed in the present invention is a ceramic tube fuse and forms an open circuit when the device under test forms a short circuit. Meanwhile, the ceramic tube fuse withstands voltage between its first and second end without generating any physical damage.

Abstract: Techniques for network communication are described herein. The disclosed techniques include generating a request for accessing a target server by a computing device, the request comprising a URL; determining whether to select a QUIC transport protocol based on the URI; selecting the QUIC transport protocol in response to a determination that the URL comprises QUIC identification information; and establishing a QUIC connection with the target server via a QUIC stack of the computing device according to the QUIC transport protocol.

Abstract: The disclosure relates to a brazing method for joining substrates, in particular where one of the substrates is difficult to wet with molten braze material. The method includes formation of a porous metal layer on a first substrate to assist wetting of the first substrate with a molten braze metal, which in turn permits joining of the first substrate with a second substrate via a braze metal later in an assembled brazed joint. Ceramic substrates can be particularly difficult to wet with molten braze metals, and the disclosed method can be used to join a ceramic substrate to another substrate. The brazed joint can be incorporated into a solid-oxide fuel cell, for example as a stack component thereof, in particular when the first substrate is a ceramic substrate and the joined substrate is a metallic substrate.