Abstract: A massager (12) includes an inductively chargeable battery (48), avoiding the need to deal with batteries and cords while providing a pleasant exothermic warmth. Different embodiments of sealing and skinning (13) make the massager (12) hygienically safe and fluid- and water-resistant. Sophisticated controls (50) provide the massager with the ability to respond to direct-mounted user controls (20, 22), wireless communication controls such as remote controls (30) and a plethora of other protocol-compatible devices, systems and media. A mating base (14) supports the massager (12) for inductive charging in a stable, aesthetically pleasant and safe relationship.

Abstract: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3?-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.

Abstract: A pointed carbon fiber electrospray ionization emitter has a length of electrically conductive fiber that is present within a lumen of a microfluidic device, and protrudes from the terminus. A point is present on an end of the electrically conductive fiber, or the electrically conductive fiber is otherwise sufficiently small on the end to create a desired spray. A conductor supplies electrical current to the electrically conductive fiber. Fluid to be sprayed is transported through the lumen and out of the terminus of the lumen, and an electrical field established by the conductive fiber distributes and sprays the fluid. The emitter is rugged and is able to generate stable electrospray over a wide range of flow rates, voltages, and surface tension variations.

Abstract: A system and method of enhancing guitar instruction based on Tablature Plus encoding of playing techniques within a MIDI file or other data structure, that may be rendered on an associated player application that provides multimedia output of the piece being played including a number of playing techniques. The system hardware for encoding the information includes string motion monitoring, and optionally a hand motion and finger positioning sensor, such as a data glove or a video motion capture system, for simultaneously registering the actions of the guitarist while playing the piece. The software comprises algorithms for determining note pitch and duration, and for extracting playing techniques from the data being collected. Multimedia player software is also described which renders a visual and audio output for the Tablature Plus encoded file, wherein the encoded playing techniques are represented within the display output. The system is adaptable to instruction for any instrument.

Abstract: A channel (140) is divised into portions (142, 144). The sidewalls of each channel portion (142, 144) have surface charges of opposite polarity. The two channel portions (142, 144) are physically connected together by a salt bridge (133), such as a glass frit or gel layer. The salt bridge (133) separates the fluids in channel (140) from an ionic fluid reservoir (135). To impart electroosmotic and electrophoretic forces along the channel (140) between parts A and B, respectively. Additionally, a third electrode (137) is placed in the reservoir (135).

Abstract: A method of copying a document onto a receiver such as paper includes taking the characteristics of the receiver into account in selecting pigments for making the copy. The characteristics may be determined by scanning the receiver to determine its color, finish, texture, etc. If the characteristics are other than a given standard such as white, the pigments necessary to render the receiver area(s) white are determined. Concurrently, the pigments needed for copying the document onto the receiver are also determined. An image processor then generates copy pigment data from the receiver and document pigments and transmits the data to a print engine in the form of toner data. If the copy pigment data might produce too dark a copy, the data is modified uniformly to reduce pigment percentages.

Abstract: A retail display system and related methods. A plastic strut is unitarily-formed with and depends from a header. The strut has a vertical array of engagement features. A plurality of product-holding elements are each engaged to an associated feature of the engagement features to secure the elements to the strut.

Abstract: A lighting system adapted to mount on a motorcycle or bicycle helmet. The lighting system includes a one or more accelerometers coupled to the helmet and a processor adapted to process the signals from the accelerometers. The accelerometers may be mounted to the helmet, or the motorcycle or bicycle. The lighting system further includes a light mounted on the helmet that is responsive to the processed signal such that the light illuminates as result of a deceleration force. The system may also include filtering software to remove helmet motion artifact and other noise from the signal. Remote wheel speed indicators may also be used in conjunction with or in place of the accelerometers. Mounting tabs may also be included to releasably attach the lighting unit to the helmet.

Abstract: Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of rare nucleic acids are provided.

Abstract: Microfluidic devices are provided for the performance of chemical and biochemical analyzes, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.

Abstract: An apparatus is provided for distributing information over a network-based environmente. The apparatus includes a first client, a server, and a second client. The server communicates with the first client via a communication link and includes a database operative to store indicia associated with at least one content object and user identifiers. The second client communicates with the server over a communication link. The second client is remote from the first client and is operative to submit indicia and a user identifier to the server. In response to submission of the indicia and the user identifier, at least one of: (a) a content object, and (b) a link to the content object are received into a personalized access point of the server. The user can access the personalized access point of the server with the first client. Methods are also provided.

Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members.

Abstract: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.

Abstract: A method of copying a document onto a receiver such as paper includes taking the characteristics of the receiver into account in selecting pigments for making the copy. The characteristics may be determined by scanning the receiver to determine its color, finish, texture, etc. If the characteristics are other than a given standard such as white, the pigments necessary to render the receiver area(s) white are determined. Concurrently, the pigments needed for copying the document onto the receiver are also determined. An image processor then generates copy pigment data from the receiver and document pigments and transmits the data to a print engine in the form of toner data. If the copy pigment data might produce too dark a copy, the data is modified uniformly to reduce pigment percentages.

Abstract: Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members.

Abstract: Molecules and methods suitable for identifying polymorphic sites in the genome of a plant or animal. The identification of such sites is useful in determining identity, ancestry, predisposition to genetic disease, the presence or absence of a desired trait, etc.

Abstract: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by incorporation of the fluorescently labeled nucleotide, optionally followed by photobleaching and intercalating dyes are used to detect addition of a non-labeled nucleotide in sequencing by synthesis with detection by intercalation. Microfluidic devices, including particle arrays, are used in the sequencing methods.

Abstract: Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.

Abstract: A channel (140) is divised into portions (142, 144). The sidewalls of each channel portion (142, 144) have surface charges of opposite polarity. The two channel portions (142, 144) are physically connected together by a salt bridge (133), such as a glass frit or gel layer. The salt bridge (133) separates the fluids in channel (140) from an ionic fluid reservoir (135). To impart electroosmotic and electrophoretic forces along the channel (140) between parts A and B, respectively. Additionally, a third electrode (137) is placed in the reservoir (135).

Abstract: The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.