Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a resilient self-expanding permeable implant having a radially constrained elongated state configured for delivery within a catheter lumen and an expanded state with a longitudinally shortened configuration, and a plurality of elongate filaments which are woven together. Each of the plurality of elongate filaments may have a diameter between about 0.0005 and about 0.005 inches. The implant includes at least some filaments consisting of nitinol and at least some composite filaments that are drawn filled tube wires comprising an external nitinol tube and a highly radiopaque material concentrically disposed within the external tube. The implant has at least about 40% composite filaments relative to a total number of filaments, and wherein a total number of filaments is about 10 to about 300.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant such as a permeable shell or mesh having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include additional mesh layers on either the inside or the outside of a first permeable shell. The distal portion of the device may be softer and deformable.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The implant may include first and second permeable shells. The first permeable shell having a proximal end with a concave or recessed section and a second permeable shell having a convex section that mates with the concave or recessed section. The implant also includes a flexible, articulating joint between the first and second permeable shells.

Abstract: A vascular prosthesis (e.g., stent), and packaging and delivery system to selectively deliver a vascular prosthesis are described. In some embodiments, the vascular prosthesis utilizes a low porosity and high porosity section, and the packaging and delivery system allows the prosthesis to be delivered such that the position of the low porosity and high porosity sections of the prosthesis can vary.

Abstract: Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Abstract: At least one ALM artifact, indexed by a unified data store, that does not comply with at least one process convention can be identified. Responsive to identifying the ALM artifact, indexed by the unified data store, that does not comply with the process convention, a determination can be made by a process convention agent executed by a processor as to whether script code is available to update the ALM artifact to comply with the process convention. Responsive to the process convention agent determining that script code is available to update the ALM artifact to comply with the process convention, the process convention agent can automatically execute the script code to update the ALM artifact to comply with the process convention.

Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract: Systems and methods for treating a stream (12) from a chemical enhanced oil recovery (CEOR) process are disclosed. The method includes contacting the feed stream (12) with a plurality of media composite particles (20) to remove hydrocarbons from the feed stream (12); and generating a treated stream (40) comprising a reduced amount of the hydrocarbons and at least a majority of the viscosity-enhancing polymer remaining therein relative to the feed stream (12). The feed stream (12) includes the hydrocarbons, a concentration of a viscosity-enhancing polymer of at least about 10 mg/L, and an aqueous fluid. The media composite particles (20) each comprise a mixture of a cellulose-based material and a polymer.

Abstract: A method of manufacturing a LIDAR chip and applying an anti-reflection (AR) coating to a coupling structure of the LIDAR chip. The coupling structure if formed on a wafer. A pocket is formed in the wafer adjacent the coupling structure. The AR material is deposited on top of the wafer and coupling structure. The AR material is etched to form the AR coating on the coupling structure.

Abstract: A parachute assembly for decelerating an occupant of an ejection seat may comprise a left shoulder riser configured to be located over a left shoulder of the occupant upon deployment of the parachute assembly. A right shoulder riser may be configured to be located over a right shoulder of the occupant upon deployment of the parachute assembly. A head restraint, configured to be behind a head of the occupant upon deployment of the parachute assembly, may be located between the left and right shoulder risers.

Abstract: An inflatable head restraint system for a parachute assembly may comprise an inflatable volume configured to inflate in response to a deployment of the parachute assembly. The inflatable volume may be located between a left shoulder riser and a right shoulder riser of the parachute assembly. A conduit may be fluidly coupled to the inflatable volume.

Abstract: A system for translating a head restraint of a parachute assembly away from a head of an occupant supported by the parachute assembly may comprise a chord coupled to the head restraint and at least one of a control line configured to manipulate a canopy of the parachute assembly or a handle coupled to the control line.

Abstract: A parachute assembly for an ejection seat may comprise a canopy and a first suspension line coupled to the canopy. A first riser may be coupled to the first suspension line. A seat cushion may be coupled to the first riser. The seat cushion may be configured detach from the ejection seat and restrict rearward translation of a head of an occupant of the ejection seat upon deployment of the parachute assembly.

Abstract: A Lidar system, photonic chip and method of detecting an object is disclosed. The Lidar system includes the photonic chip. The photonic chip includes a laser and a local oscillator waveguide. The laser is integrated into the photonic chip and generates a leakage energy at a back facet of the laser for use as a local oscillator beam for the photonic chip. The local oscillator waveguide receives the leakage energy as the local oscillator beam. The laser further generates a transmitted light beam through a front facet of the photonic chip, combining the leakage energy with a reflection of the transmitted light beam form an object, and detects a combination of the reflected light beam and the leakage energy to determine a parameter of the object.

Abstract: A vehicle, Lidar system and method of detecting an object is disclosed. The Lidar system includes a photonic chip having an aperture, one or more photodetectors and a circulator. A transmitted light beam generated within the photonic chip exits the photonic chip via the aperture and a reflected light beam enters the photonic chip via the aperture, the reflected light beam being a reflection of the transmitted light beam from the object. The one or more photodetectors measure the parameter of the object from at least the reflected light beam. The circulator integrated into the photonic chip directs the transmitted light beam toward the aperture and directs the reflected light beam from the aperture to the one or more photodetectors. A navigation system navigates the vehicle with respect to the object based on the parameter of the object.

Abstract: A vehicle, Lidar system and method of detecting an object is disclosed. The Lidar system includes a photonic chip, and a laser integrated into the photonic chip. The laser has a front facet located at a first aperture of the photonic chip to direct a transmitted light beam into free space. A reflected light beam that is a reflection of the transmitted light beam is received at the photonic chip and a parameter of the object is determined from a comparison of the transmitted light beam and the reflected light beam. A navigation system operates the vehicle with respect to the object based on a parameter of the object.

Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Abstract: A chip-scale LIDAR (light detection and ranging) system, optical package and LIDAR platform. The system includes a photonic chip, a laser associated with the photonic chip, an optical circulator, and a MEMS scanner. The laser, the optical circulator and the MEMS scanner are collinear. The photonic chip includes an edge coupler. The optical package includes a housing having an aperture, and a platform within the housing. The platform includes the laser, an optical circulator, and MEMS scanner.

Abstract: Mechanisms are provided for caching patient information in a variable list and using the variable list to evaluate patient rules. The mechanisms generate a patient registry comprising a plurality of patient registry records, each patient registry record being associated with a corresponding patient and comprising personal and medical information about the corresponding patient. The mechanisms compile at least one variable list for an input variable of one or more clinical rules. The variable list comprises a plurality of instances of personal and medical information from the plurality of sources that are associated with the variable. The mechanisms also process at least one clinical rule in the one or more clinical rules that references the variable as a criteria for evaluating the at least one clinical rule, based on the variable list associated with the variable to determine if the criteria is satisfied by one or more instances.

Abstract: Mechanisms are provided for communicating with a patient. The mechanisms generate a patient registry comprising a plurality of patient registry records, each patient registry record being associated with a corresponding patient and comprising personal and medical information about the corresponding patient. The mechanisms collect, for each patient registry record, first data regarding treatment of the corresponding patient and second data regarding communications made with the corresponding patient. The mechanisms determine, based on analysis of the first data and second data associated with each of the patient registry records, a mode of communication that is most likely to result in a successful treatment of patients. The mechanisms initiate a communication with a patient of interest using the determined mode of communication based on the results of the determination.