Abstract: A wrist joint comprises first and second joint features, the first joint feature having a first end surface profile defining a central protrusion, a first outer protrusion, a second outer protrusion, a first recess, and a second recess, wherein the first recess and the second recess are on opposite sides of the central protrusion and between the first outer protrusion and the second outer protrusion, and the second joint feature having a second end surface profile defining a central recess, a first outer recess, a second outer recess, a first protrusion between the central recess and the first outer recess, and a second protrusion between the central recess and the second outer recess, wherein the first protrusion and the second protrusion have an end surface profile different from the end surface profile of the first outer protrusion, the second outer protrusion, and the central protrusion.

Abstract: Systems and methods for identifying regions of aneuploidy in a tissue include obtaining nucleic acid sequence reads, each including a spatial barcode, associating the read with a feature in a two-dimensional array of features on a substrate contacting the tissue, and a unique molecular identifier (UMI). The reads serve to determine a count data structure comprising, for each of a plurality of genomic regions, a respective UMI count for each feature in the two-dimensional array of features on the substrate. For each feature in the array of features, a respective bin count is made for each respective bin in a plurality of bins corresponding to the respective feature, where the plurality of bins span a genome. Copy number state respective features in the array are determined using feature bin counts. The copy number state of each feature in the array of features serves to identify regions of tissue aneuploidy.

Abstract: A method includes detecting, by an implantable medical device (IMD), attachment to the IMD of at least one implantable medical lead with at least one electrode; and triggering by the IMD, based on the detecting of the attachment to the IMD of the at least one medical lead, a device test sequence in which the IMD performs the following qualification tests over an evaluation period: detecting an impedance for at least one electrical path that includes the at least one electrode to determine a connection status of the IMD to the at least one electrode; and comparing EGM (electrogram) amplitudes of the patient over an EGM test period against a predetermined threshold.

Abstract: A computer implemented method of predicting a future maintenance event of a pumping equipment on a wellbore pumping unit comprising loading a pump usage log and a pump maintenance log into a predictive maintenance model. The predictive maintenance model is trained by a machine learning process with a historical database of completed pumping jobs. The predictive maintenance model determines a probability of a future maintenance event in response to the current pump usage. The unit controller displays an alert of the remaining pump life in comparison to a threshold value for a recommended pump maintenance period or a required pump maintenance period.

Abstract: A gripper for gripping a workpiece includes: a base; at least one middle segment pivotally connected to the base; a distal segment pivotally connected to the at least one middle segment; at least one actuator disposed within the base; an adducting tendon having a proximal end attached to the at least one actuator and a distal end attached to the distal segment, the at least one actuator being configured for linearly and nonrotationally moving the proximal end of the adducting tendon; and an abducting tendon having a proximal end attached to the base and a distal end attached to the distal segment, wherein the middle segment and the distal segment are configured for gripping the workpiece as the at least one actuator moves in a first direction and ungripping the workpiece as the at least one actuator moves in a second direction which is opposite to the first direction.

Abstract: An oral irrigator handle including a housing and a first fitting, the first fitting including a first fitting inlet in fluid communication with a handle inlet in fluid communication with a fluid source and a first fitting outlet in fluid communication with the first fitting inlet. The handle includes a seal positioned around the first fitting and between the first fitting inlet and the first fitting outlet. A second fitting includes a second fitting inlet in fluid communication with the first fitting outlet and a second fitting outlet in fluid communication with the second fitting inlet. A bottom portion of the second fitting seats on a portion of the first fitting so that the seal engages an interior surface of the second fitting, a flow passage is coupled to the second fitting and in fluid communication with the second fitting outlet.

Abstract: A method of configuring a flow control valve of a mixing system may comprise establishing a flow loop via a pump, a flow control valve, and a flow rate sensor. The method may also include performing a valve configuration process that includes positioning the flow control valve in a first position, operating the pump to communicate a fluid via the flow loop at a first speed, measuring a first periodic dataset while the fluid is communicated via the flow loop, and recording the first periodic dataset. The method may also include comparing a result of the valve configuration process to a valve position dataset and an operational indicator set and determining an pass/fail status based upon the comparison, and outputting, by the unit controller, indicia of the pass/fail status of the mixing system via the input output device.

Abstract: A method of determining a health status of a mixing system may comprise establishing a flow loop via a pump, a flow control valve, and a flow rate sensor. The method may also include performing a diagnostic test that includes positioning the flow control valve in a first position, operating the pump to communicate a fluid via the flow loop at a first speed, measuring a first periodic dataset while the fluid is communicated via the flow loop, and recording the first periodic dataset. The method may also include comparing a result of the diagnostic test to an operational indicator set, determining the health status based upon the comparison of the result of the diagnostic test and the operational indicator set, and outputting, by the unit controller, indicia of the health status of the mixing system via the input output device.

Abstract: A method of configuring a flow control valve of a mixing system may comprise establishing a flow loop via a pump, a flow control valve, and a flow rate sensor. The method may also include performing a valve configuration process that includes positioning the flow control valve in a first position, operating the pump to communicate a fluid via the flow loop at a first speed, measuring a first periodic dataset while the fluid is communicated via the flow loop, and recording the first periodic dataset.

Abstract: In an embodiment, a system may support programmable hashing of address bits at a plurality of levels of granularity to map memory addresses to memory controllers and ultimately at least to memory devices. The hashing may be programmed to distribute pages of memory across the memory controllers, and consecutive blocks of the page may be mapped to physically distant memory controllers. In an embodiment, address bits may be dropped from each level of granularity, forming a compacted pipe address to save power within the memory controller. In an embodiment, a memory folding scheme may be employed to reduce the number of active memory devices and/or memory controllers in the system when the full complement of memory is not needed.

Abstract: An adjustable knee wedge may include a wedge shaped first compressible block, a wedge shaped second compressible block releasably coupled to the wedge shaped first compressible block and a leg guard mounting interface coupled to at least one of the first compressible block and the second compressible block.

Abstract: An implantable medical device system receives a cardiac electrical signal produced by a patient's heart and comprising atrial P-waves and delivers a His bundle pacing pulse to the patient's heart via a His pacing electrode vector. The system determines a timing of a sensed atrial P-wave relative to the His bundle pacing pulse and determines a type of capture of the His bundle pacing pulse in response to the determined timing of the atrial P-wave.

Abstract: A surgical instrument may comprise an elongated shaft extending between a proximal end and a distal end and defining a longitudinal axis. The surgical instrument may also comprise a plurality of cables extending along the longitudinal axis and a first bending section positioned between the proximal end and the distal end of the elongated shaft. The first bending section may comprise links having pairs of articulation holes extending longitudinally through the links to permit the plurality of pull wires to pass therethrough. Each pair of articulation holes may comprise first and second articulation holes that are spaced apart from the longitudinal axis (i) at different radii and (ii) at a same rotation angle.

Abstract: Synthetic cannabinoid compounds for treatment of epilepsy, substance addiction, and Alzheimer's disease by administering to an individual in need thereof a pharmaceutical composition including a compound having the structure: or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle therefor.

Abstract: An apparatus useful for creating and measuring states of an entangled system, comprising a pair of interacting multi-level systems, each of systems comprising a state |g>; a state |r>, and state |r*>. One or more first electromagnetic fields excite a first transition between the ground state |g> and the state |r> to create an entangled system. One or more second electromagnetic fields are tuned between the state |r> and the intermediate state |r*> so that any population of the systems in |r*> are dark to a subsequent detection of a population in the systems in |g>, providing a means to distinguish the entangled system in the state |g> and the entangled system in the state |r>. In one or more examples, the systems comprise neutral Rydberg atoms.

Abstract: Devices, systems, implants and methods for achieving ligament fixation are disclosed. An implant includes a head member and an anchor member coupled to the head member. The implant includes tension member that couples the head member to the anchor member. The head member and the anchor member include a cannulation that receives the tension member therein. The implant may include a coupling member positioned between and coupling the head member and the anchor member, the coupling member including a cannulation that receives the tension member therethrough. Insertion instruments for inserting an implant for ligament fixation are also disclosed. Methods of using an implant for achieving ligament fixation are also disclosed.

Abstract: A wellbore pumping unit comprising a main pump, a power source, a controller, and a plurality of sensors is provided. A method of performing a diagnostic check of the unit controller and the plurality of sensors when power is applied to the unit controller. A diagnostic application executing in memory writes a status of the plurality of analog inputs of a plurality of valve position sensors, a status of a plurality of frequency inputs of a plurality of flowmeters, and a plurality of calibration data files that correlate to a plurality of sensors to a diagnostic report file. The status of the sensor inputs and calibration data files can be a pass or a fail. The status of the sensor inputs can be displayed on a human machine interface.

Abstract: The present disclosure generally relates to methods, systems and compositions for determining the presence or absence of prostate cancer in a subject, treating prostate cancer in a subject, and monitoring the efficacy of a treatment regimen for prostate cancer in a subject. The methods of the present disclosure comprise determining the expression levels and spatial locations of two or more analytes in a sample from a subject and correlating the expression levels and spatial locations to a prostate sample from a subject, thereby determining the presence or absence of prostate cancer, determining a treatment regimen for prostate cancer, or monitoring the efficacy of an existing treatment regimen in a subject undergoing treatment for prostate cancer.

Abstract: Systems and methods for entropy-based treatment in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating a neurological condition, including obtaining a functional magnetic resonance imaging (fMRI) scan of a patient's brain, identifying a plurality of regions of interest (ROIs) in the fMRI scan, calculating entropy metrics for each ROI in the plurality of ROIs, selecting a treatment from a plurality of treatments for the neurological condition based on the entropy metrics, and provide the selected treatment to the patient. In a further embodiment, calculating entropy metrics includes generating multiscale entropy curves for each ROI, calculating the area under each entropy curve, assigning each ROI as positive or negative sign based on the entropy curve of each ROI, generating a similarity index for each ROI, and signing the similarity index for each ROI using the assigned sign of each ROI.

Abstract: An oral irrigator including a reservoir, a handle, a housing, a bezel positioned at least partially within and secured to the housing, and an actuator operably coupled to the housing and movable relative thereto is disclosed. The actuator includes a control shaft extending from the interior surface of the face and positioned inwards from an outer perimeter of front wall. The control shaft extends through an aperture in the housing and movement of a gripping body causes the control shaft to directly actuate a switch or a pressure assembly positioned within the housing. The actuator also includes an augmentation fluid positioned between the bezel and a portion of the actuator. The augmentation fluid modifies a frictional relationship between the bezel and the actuator to provide a predefined resistance force between the actuator and the bezel as the actuator is rotated relative to the bezel.