Abstract: The present disclosure generally relates to methods, systems and compositions for determining the presence or absence of prostate cancer in a subject, treating prostate cancer in a subject, and monitoring the efficacy of a treatment regimen for prostate cancer in a subject. The methods of the present disclosure comprise determining the expression levels and spatial locations of two or more analytes in a sample from a subject and correlating the expression levels and spatial locations to a prostate sample from a subject, thereby determining the presence or absence of prostate cancer, determining a treatment regimen for prostate cancer, or monitoring the efficacy of an existing treatment regimen in a subject undergoing treatment for prostate cancer.

Abstract: Systems and methods for entropy-based treatment in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating a neurological condition, including obtaining a functional magnetic resonance imaging (fMRI) scan of a patient's brain, identifying a plurality of regions of interest (ROIs) in the fMRI scan, calculating entropy metrics for each ROI in the plurality of ROIs, selecting a treatment from a plurality of treatments for the neurological condition based on the entropy metrics, and provide the selected treatment to the patient. In a further embodiment, calculating entropy metrics includes generating multiscale entropy curves for each ROI, calculating the area under each entropy curve, assigning each ROI as positive or negative sign based on the entropy curve of each ROI, generating a similarity index for each ROI, and signing the similarity index for each ROI using the assigned sign of each ROI.

Abstract: An oral irrigator including a reservoir, a handle, a housing, a bezel positioned at least partially within and secured to the housing, and an actuator operably coupled to the housing and movable relative thereto is disclosed. The actuator includes a control shaft extending from the interior surface of the face and positioned inwards from an outer perimeter of front wall. The control shaft extends through an aperture in the housing and movement of a gripping body causes the control shaft to directly actuate a switch or a pressure assembly positioned within the housing. The actuator also includes an augmentation fluid positioned between the bezel and a portion of the actuator. The augmentation fluid modifies a frictional relationship between the bezel and the actuator to provide a predefined resistance force between the actuator and the bezel as the actuator is rotated relative to the bezel.

Abstract: A bone fusion method, system and device for insertion between bones that are to be fused together and/or in place of one or more of the bones, such as, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable tabs having a central rib. The bone fusion device includes one or more support channels configured to receive an insertion instrument that is then secured to the bone fusion device via a coupling mechanism. As a result, the coupled device is able to be securely positioned between vertebrae using the insertion instrument with minimal risk of slippage.

Abstract: A user-specific model of muscular activity can be used to control an external device based on muscular activity within a limb of a user. The user-specific model of muscular activity can include single movements and corresponding one or more primary muscle patterns. New single movements can be added to the user-specific model of muscular activity can be by a system that includes a processor by receiving user-specific EMG signals (including one or more EMG patterns that indicate a single movement); decomposing the user-specific EMG signals into the one or more EMG patterns in EMG feature space that indicate the single movement; and updating the user-specific model of muscular activity to include the single movement and corresponding one or more primary muscle patterns based on the one or more EMG patterns in EMG feature space.

Abstract: Techniques are disclosed relating to an I/O agent circuit. The I/O agent circuit may include one or more queues and a transaction pipeline. The I/O agent circuit may issue, to the transaction pipeline from a queue of the one or more queues, a transaction of a series of transactions enqueued in a particular order. The I/O agent circuit may generate, at the transaction pipeline, a determination to return the transaction to the queue based on a detection of one or more conditions being satisfied. Based on the determination, the I/O agent circuit may reject, at the transaction pipeline, up to a threshold number of transactions that issued from the queue after the transaction issued. The I/O agent circuit may insert the transaction at a head of the queue such that the transaction is enqueued at the queue sequentially first for the series of transactions according to the particular order.

Abstract: In one embodiment, a processing device receives a first digital fingerprint of a media item along with a first content management rule. The processing device separately receives a second digital fingerprint of the media item along with a second content management rule. The processing device determines that the received digital fingerprints are for the same media item based upon a match between the first digital fingerprint and the second digital fingerprint. The processing device determines that all rights to the media item have been accounted for, and then determines a set of actions to be performed for hosted media items comprising the media item based at least in part upon the first content management rule and the second content management rule. Processing logic may also perform a conflict resolution process for conflicting rights claims to the media item.

Abstract: Techniques are disclosed relating to an I/O agent circuit. The I/O agent circuit may include a transaction pipeline and a pool of counters. The I/O agent circuit may initialize a first counter included in the pool of counters with an initial counter value. The I/O agent circuit may assign the first counter to a specific transaction type. The I/O agent circuit may increment the first counter as a part of allocating a transaction of a transaction type included in a set of transaction types different than the specific transaction type. Based on receiving a transaction request to process a first transaction of the specific transaction type, the I/O agent circuit may bind the first transaction to the first counter. The I/O agent circuit may issue the first transaction to the transaction pipeline based on a counter value stored by the first counter matching the initial counter value.

Abstract: An autonomous floor cleaning robot includes a robot body, a drive supporting the robot body to maneuver the robot across a floor surface, a pad holder attached to an underside of the robot body and configured to receive a removable cleaning pad, and a pad sensor configured to sense a pad type identifier on a central region of the cleaning pad. The pad type identifier includes a marker on the central region of the cleaning pad. The cleaning pad has a mounting card affixed thereto, and the pad type identifier includes an array of apertures that expose selected portions of the marker.

Abstract: An integrated circuit (IC) including a plurality of processor cores, a plurality of graphics processing units, a plurality of peripheral circuits, and a plurality of memory controllers is configured to support scaling of the system using a unified memory architecture. For example, the IC may include an interconnect fabric configured to provide communication between the one or more memory controller circuits and the processor cores, graphics processing units, and peripheral devices; and an off-chip interconnect coupled to the interconnect fabric and configured to couple the interconnect fabric to a corresponding interconnect fabric on another instance of the integrated circuit, wherein the interconnect fabric and the off-chip interconnect provide an interface that transparently connects the one or more memory controller circuits, the processor cores, graphics processing units, and peripheral devices in either a single instance of the integrated circuit or two or more instances of the integrated circuit.

Abstract: A Coanda system for controlling directions of an aircraft. The system includes a fluid passage defined in part by a casing wall having an inner surface facing the fluid passage. The fluid passage is configured to pass fluid from a first end inlet to a second end outlet. A fluid control element including a Coanda surface is disposed at the second end outlet. The fluid control element is moveable within the second end outlet to direct the fluid exiting the fluid passage between an upper gap and a lower gap, around the Coanda surface. A contour element is disposed on the inner surface of the casing wall upstream of the fluid control element, and further assists in directing the fluid to the open gap.

Abstract: A system and method for communicating supervisory information between amplifier nodes in an optical communication network utilizes modulation of an included pump source to superimpose the supervisory information on through-transmitted customer signals (or ASE associated with the amplifier if no customer traffic is present). The supervisory information (which may include monitoring messages, provisioning data, protocol updates, and the like) is utilized as an input to an included modulator, which then forms a drive signal for the pump controller. In a preferred embodiment, binary FSK modulation is used.

Abstract: A reflective wire grid polarizer (WGP) can include an array of wires 12 on a face of a substrate 11, with channels 15 between adjacent wires 12. The wires 12 can have certain characteristics for WGP performance, such as index of refraction, alternating high/low index continuous thin films, thickness of layer(s), duty cycle, reflective rib shape, a curved side of transparent ribs 21 or 32, aspect ratio, or combinations thereof.

Abstract: A computing device may be communicably coupled to a first pacemaker implanted in a heart of a patient and a second pacemaker implanted in the heart of the patient. The computing device may receive, from the first pacemaker, first race responsive pacing data, and may receive, from the second pacemaker, second rate responsive pacing data. The computing device may synchronize, based at least in part on the first rate responsive pacing data and the second rate responsive pacing data, rate responsive pacing of the first pacemaker and the second pacemaker.

Abstract: The present disclosure generally relates optical amplifier modules. In one form for example, an optical amplifier module includes a booster optical amplifier configured to increase optical power of a first optical signal. The module also includes a preamp optical amplifier configured to increase optical power of a second optical signal and a pump laser optically coupled to the booster optical amplifier and the preamp optical amplifier. The pump laser is configured to provide a booster power to the booster optical amplifier and a preamp power to the preamp optical amplifier, the preamp power is effective to induce a gain in optical power to provide a target optical power of the second optical signal from the preamp optical amplifier, and the booster power is dependent on the preamp power.

Abstract: In an embodiment, a system may support programmable hashing of address bits at a plurality of levels of granularity to map memory addresses to memory controllers and ultimately at least to memory devices. The hashing may be programmed to distribute pages of memory across the memory controllers, and consecutive blocks of the page may be mapped to physically distant memory controllers. In an embodiment, address bits may be dropped from each level of granularity, forming a compacted pipe address to save power within the memory controller. In an embodiment, a memory folding scheme may be employed to reduce the number of active memory devices and/or memory controllers in the system when the full complement of memory is not needed.

Abstract: In one example, a powdered build material supply system for additive manufacturing includes a supply deck, a dispenser to dispense a ribbon of powdered build material on to the supply deck, and a spreader to spread powdered build material from the ribbon over a work area adjacent to the supply deck.

Abstract: An optical device can comprise wires 12 on a face of a substrate 11, with channel(s) 13 between adjacent wires 12. Each wire 12 can include embedded organic moieties. Each wire 12 can include multiple ribs 31. Part or all of the wire 12, the substrate 11, or both can have a high refractive index n and a low extinction coefficient k. The optical device can have reduced separation of layers of different materials during flexing and temperature changes. The optical device can be manufactured by a method designed for improved manufacturability.

Abstract: An implantable medical device system receives a cardiac electrical signal produced by a patient's heart and comprising atrial P-waves and delivers a His bundle pacing pulse to the patient's heart via a His pacing electrode vector. The system determines a timing of a sensed atrial P-wave relative to the His bundle pacing pulse and determines a type of capture of the His bundle pacing pulse in response to the determined timing of the atrial P-wave.