Abstract: Systems and methods for population health surveillance utilizing a network of smart thermometers is provided. Based on the geolocated user data provided by the smart thermometers, contagious illness can be forecasted for various population nodes. Population nodes can be provided at various levels of granularity. Geographic or population specific early warning signals can be generated based on detected outbreaks of contagious illness.

Abstract: A small imager mounted on a user's eye (referred to as a femtoimager) is coordinated with an external camera. The femtoimager may be contained in a contact lens, and it may be aligned with the gaze a user's eye. The femtoimager and external camera capture images with overlapping views of the external environment. Images from the two imagers may be compared with one another to estimate the femtoimager's view of the external environment relative to the camera's view of the external environment. This may then be used for different applications.

Abstract: Systems and methods for diurnal curve generations, tracking, and analysis are provided. Based on a user's demographic, or a user's baseline diurnal curve, insights into a user's temperature reading can be produced. Such insights can be used to, for example, assess the probability that the user is experiencing a fever, which can be used in screening for medical diagnostic testing.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: The present invention relates to ocular compositions for the controlled release of a therapeutic agent. The ocular composition comprises at least 20% w/w of a therapeutic agent; 5 to 75% w/w of a photopolymerizable composition selected from the group consisting of fragments or monomers of polyalkylene glycol mono-acrylate, polyalkylene glycol diacrylate, polyalkylene glycol methacrylate and polyalkylene glycol dimethacrylate, and mixtures, copolymers, and block copolymers thereof; 0.1 to 40% w/w of a biodegradable polymer selected from the group consisting of lactide/glycolide copolymer (including poly(lactide-co-glycolide) (PLGA)), poly (L-lactide) (PLA), polyhydroxyalkanoates, including polyhydroxybutyrate, polyglycolic acid (PGA), polycaprolactone (PCL), poly (DL-lactide) (PDL), poly (D-lactide), lactide/caprolactone copolymer, poly-L-lactide-co-caprolactone (PLC) and mixtures, copolymers, and block copolymers thereof; and a photoinitiator.

Abstract: A system for characterising a target polynucleotide, the system comprising a membrane and a pore complex; wherein the pore complex comprises: (i) a nanopore located in the membrane, and (ii) an auxiliary protein or peptide attached to the nanopore; wherein the nanopore and the auxiliary protein or peptide together form a continuous channel across the membrane, the channel comprising a first constriction region and a second constriction region; wherein the first constriction region is formed by a portion of the nanopore, and wherein the second constriction region is formed by at least a portion of the auxiliary protein or peptide.

Abstract: There are provided systems and methods for a physical card having one or more location detection modules A physical payment card may include one or more components to limit card reading of card data stored to the card using a location detection chip. The location detection chip may receive power from a source when inserted to a card reader, and may then determine a location of the card, such as a coordinate location of the card or nearby detected device. The location detection chip may determine if this location or device matches authorized locations stored in a memory of the card. If it does, power may be provided to a card chip of the card. The card chip of the card reads card data from a memory of the card and may then output the card data to the card reader.

Abstract: The present invention relates to an ocular implant for the controlled release of a therapeutic agent or drug comprising: a) at least 0.1% w/w of a therapeutic agent; b) 5 to 95% w/w of a crosslinked polymer matrix; c) and 0.

Abstract: The present disclosure relates to a method for power management of an electronic device, the method comprising determining an onset of a predefined time segment corresponding to a time period; obtaining power consumption data by monitoring at least one of a current power consumption rate, a current device state, and a current device usage pattern of the device during the predefined time segment; selecting a power consumption category for the predefined time segment based on the power consumption data; switching from a first power saving mode active on the device to a second power saving mode based on the selected power consumption category; and performing one or more operations on the device based on the second power saving mode.

Abstract: A small imager mounted on a user's eye (referred to as a femtoimager) is coordinated with an external camera. The femtoimager may be contained in a contact lens, and it may be aligned with the gaze a user's eye. The femtoimager and external camera capture images with overlapping views of the external environment. Images from the two imagers may be compared with one another to estimate the femtoimager's view of the external environment relative to the camera's view of the external environment. This may then be used for different applications.

Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: An eye-mounted device includes a contact lens that contains a femtoimager and corresponding femtoprojector. The femtoimager captures images of a user's surrounding environment. Images captured by the femtoimager are transmitted to the femtoprojector via a signal path containing digital image processing circuitry to perform one or more image processing functions on the captured images. The image processing circuitry comprises a plurality of filters connected in series and/or parallel that are configurable to implement different types of image processing, depending on the content of the images captured by the femtoimager. Compute approximation and simplification is utilized to reduce the power consumption within the lens. Components outside the contact lens determine the type of image processing, thus reducing power consumption within the contact lens. The femtoprojector then projects the resulting images to the user's retina.

Abstract: Techniques are disclosed relating to methods that include receiving an indication of an access by a user to a web page that includes a beacon, and calculating a readiness score for triggering the beacon. The methods may also include determining, based on the readiness score, whether to perform a client-side or server-side triggering of the beacon. The triggering causes data associated with the access to be transmitted to a third-party computer system.

Abstract: Analog Front End (AFE) driver or transmitter is used for ESD protection of an input-output (IO) pin, thus reducing ESD diode count and subsequently lowering the pad capacitance to achieve high performance in IO circuits like double data rate (DDR) IO, PCI Express (Peripheral Component Interconnect Express), etc. The channel of active devices that constitute AFE driver are used to connect an IO pad to discharge the ESD current to ground, thus providing an alternative path to ESD current and subsequently reducing the ESD diode count. An additional p-type device (Driver Path Enabler (DPE)) is coupled between the IO pad and a gate terminal of the AFE driver. This additional p-type device triggers the channel of the AFE driver. This p-type device is controlled by an RC based structure which cuts the p-type device off during regular operations when power is ramped-up.

Abstract: The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.

Abstract: Exemplary embodiments of the present disclosure are directed towards an artificial intelligence sterilization system and a novel process of providing outsourced sterilization services for processing surgical instruments comprising of: a GUI module along with wizards representing an interactive user interactions to direct to the next action to be performed, authentication module comprising of RFID authentication/AI facilitated control of protective gear worn by the users as well as the workspace, sterilizer's module configured to automate, control and track sterilizer level operations; cassettes module configured to automate, control and track surgical lab instruments with RFID or AI tracking and place instruments in their respective cassettes; patient's module configured to deal with the surgical lab instruments to cassettes to equipment to patient tracking; audit and reporting module configured to deal with a detailed audit report; training module providing context based training modules and reference manual

Abstract: Systems and methods for diurnal curve generations, tracking, and analysis are provided. Based on a user's demographic, or a user's baseline diurnal curve, insights into a user's temperature reading can be produced. Such insights can be used to, for example, assess the probability that the user is experiencing a fever, which can be used in screening for medical diagnostic testing.

Abstract: A digitally printed, water-activated, peel-off and slide-on permanent transfer decal includes a base layer of gum-coated decal paper comprising a cornstarch and dextrose coating having a thickness of between approximately 10 microns to approximately 30 microns, a layer of lacquer over the cornstarch and dextrose coating of the base layer, and a full-color artwork comprising a digital, UV-LED-cured printing ink printed onto the lacquer layer to form a ready-decal sheet having a decal formed by the ink and the lacquer layer. The lacquer layer has a thickness of between approximately 150 microns and approximately 300 microns, is sandwiched between the cornstarch and dextrose coating and the ink, and is bonded to the ink. The decal is permanently bonded to a surface of an object comprising at least one of ceramic, metal, stainless steel, aluminum, plastic, acrylic, wood, and glass.

Abstract: Systems and methods for population health surveillance utilizing a network of smart thermometers is provided. Based on the geolocated user data provided by the smart thermometers, contagious illness can be forecasted for various population nodes. Population nodes can be provided at various levels of granularity. Geographic or population specific early warning signals can be generated based on detected outbreaks of contagious illness.