Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: There are provided systems and methods for a physical card having one or more location detection modules for location-specific card reading. A physical payment card may include one or more components to limit card reading of card data stored to the card using a location detection chip. The location detection chip may receive power from a source when inserted to a card reader, and may then determine a location of the card, such as a coordinate location of the card or nearby detected device. The location detection chip may determine if this location or device matches authorized locations stored in a memory of the card. If it does, power may be provided to a card chip of the card. The card chip of the card reads card data from a memory of the card and may then output the card data to the card reader.

Abstract: There are provided systems and methods for a physical card having one or more location detection modules for location-specific card reading. A physical payment card may include one or more components to limit card reading of card data stored to the card using a location detection chip. The location detection chip may receive power from a source when inserted to a card reader, and may then determine a location of the card, such as a coordinate location of the card or nearby detected device. The location detection chip may determine if this location or device matches authorized locations stored in a memory of the card. If it does, power may be provided to a card chip of the card. The card chip of the card reads card data from a memory of the card and may then output the card data to the card reader.

Abstract: The present disclosure relates to a method for power management of an electronic device, the method comprising determining an onset of a predefined time segment corresponding to a time period; obtaining power consumption data by monitoring at least one of a current power consumption rate, a current device state, and a current device usage pattern of the device during the predefined time segment; selecting a power consumption category for the predefined time segment based on the power consumption data; switching from a first power saving mode active on the device to a second power saving mode based on the selected power consumption category; and performing one or more operations on the device based on the second power saving mode.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.

Abstract: A scleral contact lens has a core containing an optical filter. The core and/or the optical filter may comprise oxygen impermeable material, such that an overall oxygen permeability of the core is insufficient to oxygenate a user's cornea when wearing the contact lens. To provide oxygenation to the user's cornea, the contact lens further comprises an outer covering, and an inner covering, each corresponding to a thin layer of gas-permeable material shaped to form a respective manifold between the covering and the core. Oxygen from an outside environment passes through the outer covering to reach the outer manifold, through an air path formed within the core to the inner manifold, and through the inner covering to reach the cornea of the user's eye.

Abstract: Epigrammar is a cloud-based software application that lets users on a multi-user access document retrieve annotations from closed files for reuse on an open file and retrieve annotations from closed files for reuse on a new document (i.e. log). When users or authorized users make an annotation (called an, “Epigram,” online) on some file that has been shared to Epigrammar in any file format, that annotation and its relevant data are stored in a general repository providing context for the note. Thus, users never need to open an annotation's corresponding file in order to recover valuable information. Due to mapping information stored in the form of x- and y-coordinates, the precise point of any annotation may be found by selecting any annotation from a general inventory of annotations to facilitate activity online.

Abstract: A system for providing energy to a bio-implantable medical device includes an acoustic energy delivery device and a bio-implantable electroacoustical energy converter. The acoustic energy delivery device generates acoustic energy with a multi-dimensional array of transmitting electroacoustical transducers. The acoustic energy is received by one or more receiving electroacoustical transducers in the bio-implantable electroacoustical energy converter. The receiving electroacoustical transducers convert the acoustic energy to electrical energy to power the bio-implantable medical device directly or indirectly. An external alignment system provides lateral and/or angular positioning of an ultrasound energy transmitter over an ultrasound energy receiver. The acoustic energy transmitter alignment system comprises either or both x-y-z plus angular positioning components, and/or a substantially multi-dimensional array of transmitters plus position sensors in both the transmitter and receiver units.

Abstract: Exemplary embodiments of the present disclosure are directed towards an artificial intelligence sterilization system and a novel process of providing outsourced sterilization services for processing surgical instruments comprising of: a GUI module along with wizards representing an interactive user interactions to direct to the next action to be performed, authentication module comprising of RFID authentication/AI facilitated control of protective gear worn by the users as well as the workspace, sterilizer's module configured to automate, control and track sterilizer level operations; cassettes module configured to automate, control and track surgical lab instruments with RFID or AI tracking and place instruments in their respective cassettes; patient's module configured to deal with the surgical lab instruments to cassettes to equipment to patient tracking; audit and reporting module configured to deal with a detailed audit report; training module providing context based training modules and reference manual

Abstract: Provided herein relate to modified or mutant forms of secretin and compositions comprising the same. In particular, the modified or mutant forms of secretin permits efficient capture and/or translocation of an analyte through the modified or mutant secretin nanopores. Methods for using unmodified secretin or the modified or mutant forms of secretin and compositions, for example, for characterizing an analyte, e.g., a target polynucleotide, are also provided.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: A system for providing energy to a bio-implantable medical device includes an acoustic energy delivery device and a bio-implantable electroacoustical energy converter. The acoustic energy delivery device generates acoustic energy with a multi-dimensional array of transmitting electroacoustical transducers. The acoustic energy is received by one or more receiving electroacoustical transducers in the bio-implantable electroacoustical energy converter. The receiving electroacoustical transducers convert the acoustic energy to electrical energy to power the bio-implantable medical device directly or indirectly. An external alignment system provides lateral and/or angular positioning of an ultrasound energy transmitter over an ultrasound energy receiver. The acoustic energy transmitter alignment system comprises either or both x-y-z plus angular positioning components, and/or a substantially multi-dimensional array of transmitters plus position sensors in both the transmitter and receiver units.

Abstract: A digitally printed, water-activated, peel-off and slide-on permanent transfer decal includes a base layer of gum-coated decal paper comprising a cornstarch and dextrose coating having a thickness of between approximately 10 microns to approximately 30 microns, a layer of lacquer over the cornstarch and dextrose coating of the base layer, and a full-color artwork comprising a digital, UV-LED-cured printing ink printed onto the lacquer layer to form a ready-decal sheet having a decal formed by the ink and the lacquer layer. The lacquer layer has a thickness of between approximately 150 microns and approximately 300 microns, is sandwiched between the cornstarch and dextrose coating and the ink, and is bonded to the ink. The decal is permanently bonded to a surface of an object comprising at least one of ceramic, metal, stainless steel, aluminum, plastic, acrylic, wood, and glass.

Abstract: A system for providing energy to a bio-implantable medical device includes an acoustic energy delivery device and a bio-implantable electroacoustical energy converter. The acoustic energy delivery device generates acoustic energy with a multi-dimensional array of transmitting electroacoustical transducers. The acoustic energy is received by one or more receiving electroacoustical transducers in the bio-implantable electroacoustical energy converter. The receiving electroacoustical transducers convert the acoustic energy to electrical energy to power the bio-implantable medical device directly or indirectly. An external alignment system provides lateral and/or angular positioning of an ultrasound energy transmitter over an ultrasound energy receiver. The acoustic energy transmitter alignment system comprises either or both x-y-z plus angular positioning components, and/or a substantially multi-dimensional array of transmitters plus position sensors in both the transmitter and receiver units.

Abstract: The invention provides an ocular composition comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent. The composition can be used to form an ocular implant and an in situ ocular implant.

Abstract: A method of creating a digitally printed, water-activated, peel-off and slide-on decal for permanent transfer to an object includes the steps of printing a layer of lacquer on top of a base layer of gum-coated decal paper comprising a cornstarch and dextrose coating having a thickness of between approximately 10 microns to approximately 30 microns, drying the lacquer layer for no more than 90 minutes, printing a full-color artwork with digital, light-cured printing ink in one printing pass onto the lacquer layer to produce a ready-decal sheet having a decal formed by the ink and the lacquer layer, the lacquer layer bonding to the ink and being sandwiched between the cornstarch and dextrose coating and the ink and—having a thickness of between approximately 150 micrometers and approximately 300 micrometers, and—curing the ink with light.

Abstract: Methods are provided for controlling a vehicle engine to improve engine efficiency utilizing onboard water condensate. In one example, condensate is collected from cooling air routed into an engine, and injected into one of a plurality of locations based on engine operating conditions to keep NOx in combustion gases below desired amounts and to avoid ignition knock in said engine. In this way, condensate build-up in the CAC is advantageously utilized, engine performance and efficiency may be improved, and harmful emissions may be reduced.

Abstract: Paired bones are individually secured in an anatomically relevant manner onto independent, parallel positioned platforms, and configured into motorized models for the purpose of teaching and assessing clinicians' ability to identify and compare the relative positions of bony landmarks within the coronal and sagittal planes. One platform can be powered by two motors to generate precise landmark asymmetries, moving the platforms in the coronal plane and around a horizontal axis. As the platform shears upward or rotates forward, the landmarks on the bone attached to that platform can be moved superiorly compared to the other side. A central computer can instruct the motors of a plurality of models to move predetermined amounts via a two-way wireless communications link. The model can communicate back to the computer once the movement is completed, assuring a high level of precision in obtaining the intended positional asymmetry or informing the user that the move exceeds the limits of the model.