Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: Mechanisms are provided for performing a matrix operation. A processor of a data processing system is configured to perform cluster-based matrix reordering of an input matrix. An input matrix, which comprises nodes associated with elements of the matrix, is received. The nodes are clustered into clusters based on numbers of connections with other nodes within and between the clusters, and the clusters are ordered by minimizing a total length of cross cluster connections between nodes of the clusters, to thereby generate a reordered matrix. A lookup table is generated identifying new locations of nodes of the input matrix, in the reordered matrix. A matrix operation is then performed based on the reordered matrix and the lookup table.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: A method, apparatus, and computer program product are provided for generating a set of token sequences for at least a portion of a database, wherein each token in a sequence represents a respective database entity of the database; assigning, for each token in the set of token sequences, at least one corresponding vector from a set of vectors of a same dimension, wherein the at least one corresponding vector encodes relationships between the database entity of a token and other database entities of other tokens of the set of token sequences; and extracting, using a query language, information from the database based at least in part on the relationships encoded by the assigned vectors.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: Mechanisms are provided for performing a matrix operation. A processor of a data processing system is configured to perform cluster-based matrix reordering of an input matrix. An input matrix, which comprises nodes associated with elements of the matrix, is received. The nodes are clustered into clusters based on numbers of connections with other nodes within and between the clusters, and the clusters are ordered by minimizing a total length of cross cluster connections between nodes of the clusters, to thereby generate a reordered matrix. A lookup table is generated identifying new locations of nodes of the input matrix, in the reordered matrix. A matrix operation is then performed based on the reordered matrix and the lookup table.

Abstract: Detecting a denial-of-service attack on a graph database is provided. In response to receiving a request to process a graph query on the graph database from a client device via a network, a graph query pattern of the graph query is determined. In response to determining that the graph query pattern of the graph query matches a stored graph query pattern that lead to a previous denial-of-service attack on the graph database, the graph query is identified as the denial-of-service attack on the graph database. Then, the request to process the graph query is denied by dropping the graph query.

Abstract: Approaches for a memory including a cell array are provided. The memory includes a first device of the cell array which is connected to a bitline and a node and controlled by a word line, and a second device of the cell array which comprises a third device which is connected to a source line and the node and controlled by the word line and a fourth device which is connected between the word line and the node. In the memory, in response to another word line in the cell array being activated and the word line not being activated to keep the first device in an unprogrammed state, the third device isolates and floats the node such that a voltage level of a gate to source of the first device is clamped down by the fourth device to a voltage level around zero volts.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: Approaches for a memory including a cell array are provided. The memory includes a first device of the cell array which is connected to a bitline and a node and controlled by a word line, and a second device of the cell array which comprises a third device which is connected to a source line and the node and controlled by the word line and a fourth device which is connected between the word line and the node. In the memory, in response to another word line in the cell array being activated and the word line not being activated to keep the first device in an unprogrammed state, the third device isolates and floats the node such that a voltage level of a gate to source of the first device is clamped down by the fourth device to a voltage level around zero volts.

Abstract: A biomarker sensor using short peptide recognition elements. The biomarker sensor includes a substrate and a metallic layer on a surface of that substrate that is localized surface plasmon resonance reactive. A receptor layer on the surface of the metallic layer (the surface opposing the substrate) is configured to selectively bind a biomarker and has a thickness less than about 15 nm.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: The present patent application discloses at least the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein ring JB, n, JD, J, o, X, X1, J, RC, and W are as defined herein. These compounds are useful as stimulators of soluble sGC.

Abstract: Mechanisms, in a system comprising a host system and at least one accelerator device, for performing a concept analysis operation are provided. The host system extracts a set of one or more concepts from an information source and provides the set of one or more concepts to the accelerator device. The host system also provides at least one matrix representation data structure representing a graph of concepts and relationships between concepts in a corpus. The accelerator device executes the concept analysis operation internal to the accelerator device to generate an output vector identifying concepts in the corpus, identified in the at least one matrix representation data structure, related to the set of one or more concepts extracted from the information source. The accelerator device outputs the output vector to the host system which utilizes the output vector to respond to a request submitted to the host system associated with the information source.

Abstract: A system and method of operating a twin-transistor single bit multi-time programmable memory cell to provide a high gain, sensing scheme for small signals. The memory cell includes a pair of a first transistor and a second transistor providing a differential signal output. The first transistor of the memory cell couples a first circuit leg having a first current source load transistor and the second transistor couples a second circuit leg having a second current source load transistor. A programmed value is represented by a voltage threshold shift in one of the first or second transistors. A feedback circuit receives one of: a first signal or a second signal of the differential signals, and generates, in response, a feedback signal which is simultaneously applied to bias each current source load transistor in each the first and second circuit legs to amplify a voltage differential between the differential signal outputs.

Abstract: Mechanisms are provided for performing a matrix operation. A processor is configured to perform hybrid compressed representation matrix operations on an input matrix that comprises zero value and non-zero value entries. A first compressed representation data structure corresponding to the input matrix, and a second compressed representation data structure are obtained, each utilizing a different format for representing the non-zero value entries of the input matrix. A matrix operation is iteratively executed on the input matrix using the first compressed representation data structure and the second compressed representation data structure. The first compressed representation data structure is utilized for a first subset of iterations of the matrix operation and the second compressed representation data structure is utilized for a second subset of iterations of the matrix operation different from the first subset of iterations.

Abstract: Mechanisms are provided for performing a matrix operation. A processor of a data processing system is configured to perform cluster-based matrix reordering of an input matrix. An input matrix, which comprises nodes associated with elements of the matrix, is received. The nodes are clustered into clusters based on numbers of connections with other nodes within and between the clusters, and the clusters are ordered by minimizing a total length of cross cluster connections between nodes of the clusters, to thereby generate a reordered matrix. A lookup table is generated identifying new locations of nodes of the input matrix, in the reordered matrix. A matrix operation is then performed based on the reordered matrix and the lookup table.