Abstract: A polypeptide encoding a chimeric antigen receptor (CAR) comprising at least one extracellular binding domain that comprises a scFv formed by at least a VH chain and a VL chain specific to an antigen, wherein said extracellular binding domain comprises at least one mAb-specific epitope.

Abstract: Described herein is an add-on device for an intravenous (IV) set hand pump comprising a first member configured to actuate the handpump, a second member hingedly connected to the first member and configured to receive the hand pump, wherein, when actuated, the add-on device is configured to increase a fluid flow rate downstream of the IV set hand pump beyond a maximum gravity-based fluid flow rate of the IV set.

Abstract: Methods of identifying and using PSGL-1 antagonists are provided. Such methods include, but are not limited to, methods of treating cancer. PSGL-1 antagonists include, but are not limited to, antibodies that bind PSGL-1 and antibodies that bind VISTA, wherein the antibodies inhibit PSGL-1 binding to VISTA, e.g., at acidic pH (e.g., pH 6.0), as well as PSGL-1 and VISTA extracellular domain polypeptides.

Abstract: An adapter for mounting cable hangers to a mounting structure includes: a plurality of mounting panels, each mounting panel including a mounting hole, the mounting panels attached to each other at edges thereof, each mounting panel being disposed at an angle relative to its adjacent mounting panels; a base attached to the edge of endmost ones of the mounting panels; wherein the mounting panels and the base define an interior of the adapter; the adapter further comprising at least one pair of fingers extending into the interior of the adapter, each pair of fingers being configured to cooperate to grasp a cable.

Abstract: Fluid connectors assemblies that provide neutral fluid displacement without overlapping connectors are disclosed. A fluid connector assembly may include a housing and a pair of connectors (e.g., luers) coupled with the housing. A compressible member is located within the housing. The first connector and the second connector each include a post with an opening. The compressible member can seal off the opening of the first connector from fluid entry. However, when the post of the second connector is inserted into the housing, the post of the second connector displaces the compressible member, causing the compressible member to create a fluid path, thereby allowing fluid to flow through the internal volume of the housing. Further, the compressible member seals the housing until each of the first connector and the second connector are coupled therewith forming a fluid path through the posts.

Abstract: A coupler including a first connector having a first end, a second end opposite the first end, and a first valve disposed between the first end and the second end. The first valve having a compressed state and an expanded state. The coupler includes a second connector having a housing, a connecting portion extending from the housing, and a second valve disposed at least partially within the housing, the second valve having a compressed state and an expanded state. The coupler further includes a collar coupled to the housing of the second connector and configured to receive at least a portion of the first connector to detachably couple the first connector to the collar and the second connector such that the housing of the second connector is at least partially disposed within the first connector.

Abstract: Methods, systems, and storage media for managing digital entitlements are disclosed. Exemplary implementations may: determine at least one digital entitlement; generate a digital backpack; select a third party platform; generate an application program interface (API) call associated with the at least one digital entitlement to a third party application; and store the at least one entitlement in the digital backpack.

Abstract: An insert for mounting multiple cables in a cable hanger includes: a gripping portion configured to engage multiple cables; and a wrapping portion attached to the gripping portion and configured to wrap around the gripping portion as it receives cables.

Abstract: Devices, methods, and systems may obtain at least one point cloud, segment points in the at least one point cloud into a plurality of segments, train a neural network using known segments and a first loss function to generate a first trained neural network, train the first trained neural network using outlier segments and a second loss function to generate a second trained neural network, and train an extended isolation forest by applying an extended isolation algorithm to features of the known segments and features of the outlier segments to generate an anomaly score for each segment.

Abstract: Aspects of the disclosure relate to a distributed evaluation platform. The distributed evaluation platform may train a machine learning model based on historical nonfungible tokens. The distributed evaluation platform may receive client information from a client device. The distributed evaluation platform may generate NFTs corresponding to the client information. The distributed evaluation platform may generate soft tokens corresponding to each NFT. The distributed evaluation platform may apply test cases to the soft tokens. The distributed evaluation platform may generate remedial tokens based on the soft tokens and remediation actions. The distributed evaluation platform may apply the test cases to the remedial tokens. The distributed evaluation platform may overwrite the NFTs using the remedial tokens. The distributed evaluation platform may send an event processing request to an event processing system. The distributed evaluation platform may refine the machine learning model based on the NFTs.

Abstract: A cable hanger includes: a base panel having opposed ends; a pair of arms, each of the arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; and a pair of gripping members, each gripping member attached to a respective arm, each gripping member having opposed ends, wherein one of the ends of each gripping member is fixed to the arms and the other of the ends of each gripping member is fixed to the arm or to the base panel. The arms and locking projections are configured to spread apart to enable insertion of a cable between the arms, wherein the gripping projections engage and grip the cable, and wherein the locking projections are configured to be inserted into the aperture of the supporting structure.

Abstract: Fluid connectors assemblies that provide neutral fluid displacement without overlapping connectors are disclosed. A fluid connector assembly may include a housing and a pair of connectors (e.g., luers) coupled with the housing. A compressible member (e.g., bellow) is located within the housing. The first connector and the second connector each include a post with an opening. The compressible member can seal off the opening of the first connector from fluid entry. However, when the post of the second connector is inserted into the housing, the post of the second connector displaces the compressible member, causing the compressible member to uncover the opening, and further causes the compressible member to open in another location and receive fluid. Further, the compressible member seals each of the first connector and the second connector and forms a fluid path through the posts and the compressible member, with the seals regulating fluid flow.

Abstract: Provided herein are heavy chain constant regions (referred to as “modified heavy chain constant regions”), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains (i.e., CH1, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.

Abstract: Methods, systems, computer-readable media, and apparatuses for providing service to access nodes are presented. In some embodiments, a computing device may generate a geographical coverage map comprising a plurality of wireless access nodes respectively at a plurality of geographic locations and a wireless coverage range for each wireless access node. The computing device may receive from at least one wireless access node of the plurality of wireless access nodes an indication that the at least one wireless access node detected a first wireless access node of the plurality of wireless access nodes. The computing device may refine a first coverage range of the first wireless access node based on a respective geographic location of the at least one wireless access node. In some embodiments, a first wireless access node may receive and forward join emergency mesh (JEM) messages to establish a wireless network.

Abstract: A request to activate a service may be received from a user device and a determination may be made as to whether the request is authorized or fraudulent. In particular, a geographical location of the user device may be determined. Whether to activate the service may be determined based on the geographical location of the user device.

Abstract: A lithium-ion battery and methods thereof are disclosed. In an aspect, the lithium-ion battery includes an anode component, a cathode component, a separator, and an electrolyte. The anode component includes an anode current collector and a respective anode coating on each side of the anode current collector. An anode coating includes composite particles including carbon and silicon. A mass fraction of the silicon in the composite particles of the anode coatings may be in a range of about 5 wt. % to about 70 wt. % of the anode coatings. The anode component undergoes a maximum areal expansion (Amax) during the multiple charging and discharging cycles. The anode current collector comprises a copper foil, the copper foil being characterized, before the respective anode coatings are formed thereon, by an ultimate tensile stress (UTS) and a strain at the UTS (?UTS).

Abstract: The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Abstract: A data management system may support a configuration backup of a first backup system that manages backup procedures for data of a host environment that is separate from the first backup system. The data management system may transmit, to the first backup system, a request to generate the configuration backup that includes information for the one or more backup procedures managed by the first backup system. The data management system may cause the configuration backup to be stored in a separate storage location. In response to first backup system failure, the data management system may transmit, to a second backup system, a request to apply one or more configurations for the first backup system to the second backup system based on the stored configuration backup for the first backup system.

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

Abstract: A method for establishing secure connectivity is described. The method may include transmitting, to one or more host nodes of a data management system (DMS), an indication of a backup service configuration that includes a public key certificate associated with a first cluster of storage nodes in the DMS and a root certificate associated with a certificate authority. The method may further include establishing a primary connection between the first cluster and the host nodes using the public key certificate. The method may further include obtaining, by a second cluster of storage nodes in the DMS, a certificate chain signed by the certificate authority. The method may further include establishing a secondary connection between the second cluster and the host nodes in response to the first cluster becoming disconnected from the host nodes, where the secondary connection is established using the certificate chain.