Patents by Inventor Rajpal .

Rajpal . has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11830386
    Abstract: A cable hanger includes: a base panel having opposed ends; a pair of arms, each of the arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; and a pair of gripping members, each gripping member attached to a respective arm, each gripping member having opposed ends, wherein one of the ends of each gripping member is fixed to the arms and the other of the ends of each gripping member is fixed to the arm or to the base panel. The arms and locking projections are configured to spread apart to enable insertion of a cable between the arms, wherein the gripping projections engage and grip the cable, and wherein the locking projections are configured to be inserted into the aperture of the supporting structure.
    Type: Grant
    Filed: January 5, 2023
    Date of Patent: November 28, 2023
    Assignee: COMMSCOPE TECHNOLOGIES LLC
    Inventors: Ronald A Vaccaro, Aviral Joshi, Taig S. Rajpal
  • Patent number: 11821550
    Abstract: An insert for mounting multiple cables in a cable hanger includes: a gripping portion configured to engage multiple cables; and a wrapping portion attached to the gripping portion and configured to wrap around the gripping portion as it receives cables.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: November 21, 2023
    Assignee: CommScope Technologies LLC
    Inventors: Taig S. Rajpal, Ronald A. Vaccaro, Aviral Joshi
  • Patent number: 11814435
    Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: November 14, 2023
    Assignee: PFIZER INC.
    Inventors: Tracy Chia-Chien Kuo, Javier Fernando Chaparro Riggers, Wei Chen, Amy Shaw-Ru Chen, Edward Derrick Pascua, Thomas John Van Blarcom, Leila Marie Boustany, Weihsien Ho, Yik Andy Yeung, Pavel Strop, Arvind Rajpal
  • Publication number: 20230358341
    Abstract: An adapter for mounting cable hangers to a mounting structure includes: a plurality of mounting panels, each mounting panel including a mounting hole, the mounting panels attached to each other at edges thereof, each mounting panel being disposed at an angle relative to its adjacent mounting panels; a base attached to the edge of endmost ones of the mounting panels; wherein the mounting panels and the base define an interior of the adapter; the adapter further comprising at least one pair of fingers extending into the interior of the adapter, each pair of fingers being configured to cooperate to grasp a cable.
    Type: Application
    Filed: July 12, 2023
    Publication date: November 9, 2023
    Inventors: Ronald A. Vaccaro, Aviral Joshi, Taig S. Rajpal
  • Publication number: 20230321425
    Abstract: Fluid connector systems that can include first and second valve assemblies that are couplable together to form a fluid pathway through the fluid connector system when the first and second valve assemblies are coupled together, and can resist fluid flow through each of the first and second valve assemblies when the first and second valve assemblies are separated from each other, where the first and second valve assemblies can include a compressible element or post positioned within a channel and configured resist fluid flow through the respective first or second valve assembly in a first position and to reduce the resistance to fluid flow through the first or second valve assembly in a second position, and the first and second valve assemblies including a sleeve and one or more arm configured to engage each other to form a snap fitting feature that can resist separation therebetween.
    Type: Application
    Filed: February 9, 2023
    Publication date: October 12, 2023
    Inventors: Amarsinh Deeliprao JADHAV, Sumit RAJPAL, Kaushik SUMAN, Kanjimpuredathil Muralikrishna MENON, Mohammed Mehtab KHAN
  • Publication number: 20230316438
    Abstract: A system that can generate unique identifiers for individual real estate parcels and/or individual structure(s) located on individual real estate parcels using geometric land and/or building information is described. For example, the system can obtain geographical coordinate information and/or topological information that defines a two-dimensional or three-dimensional boundary of a parcel. The system can then determine and assign a unique identifier to the parcel, where the unique identifier is based on the two-dimensional or three-dimensional boundary. As another example, the system can obtain geographical coordinate information and/or structure architectural plans that define a two-dimensional or three-dimensional boundary of a structure. The system can then determine and assign a unique identifier to the structure, where the unique identifier is based on the two-dimensional or three-dimensional boundary of the structure.
    Type: Application
    Filed: March 28, 2023
    Publication date: October 5, 2023
    Inventors: Frankie Famighetti, Anand Singh, Ashish Jain, Sachin Rajpal
  • Publication number: 20230295346
    Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
    Type: Application
    Filed: March 9, 2023
    Publication date: September 21, 2023
    Inventors: Stanley R. Krystek, JR., Yong Zhang, Gregory D. Vite, Arvind Rajpal, Chetana Rao-Naik, Paul E. Morin, Mohan Srinivasan, Zheng Lin, Virginie Lafont, Alla Pritsker
  • Patent number: 11765679
    Abstract: Methods, systems, computer-readable media, and apparatuses for providing service to access nodes are presented. In some embodiments, a computing device may generate a geographical coverage map comprising a plurality of wireless access nodes respectively at a plurality of geographic locations and a wireless coverage range for each wireless access node. The computing device may receive from at least one wireless access node of the plurality of wireless access nodes an indication that the at least one wireless access node detected a first wireless access node of the plurality of wireless access nodes. The computing device may refine a first coverage range of the first wireless access node based on a respective geographic location of the at least one wireless access node. In some embodiments, a first wireless access node may receive and forward join emergency mesh (JEM) messages to establish a wireless network.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: September 19, 2023
    Assignee: Comcast Cable Communications, LLC
    Inventors: Derrick Krening, Edward David Monnerat, Jonathan Alan Leech, Nicholas Adam Pinckernell, Andy Martushev, Jasbir Rajpal, Scott Moody, Garey Hoffman, David B. Leach, David O'hare
  • Publication number: 20230263554
    Abstract: Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.
    Type: Application
    Filed: April 28, 2023
    Publication date: August 24, 2023
    Inventors: Mary E. STUART, Bret W. SCHNEIDER, Francois FOLLINI, Craig S. BARTLETT, Bharat M. DESAI, Michael J. GARDNER, GianLuigi MORO, Sven H. VAN HELDEN, Kyle L. NISHKIAN, David W. POLLY, Jed S. VANICHKACHORN, Andy J. KRANENBURG, Sharad S. RAJPAL, Nikolai G. RAINOV
  • Patent number: 11706401
    Abstract: Disclosed are methods and systems for displaying content. In an aspect, a plurality of content items can be displayed on one user device according to user preference. An example method can comprise positioning a first set of pixels associated with a user device so that first content displayed via the first set of pixels can be viewable in a first viewing location. A second set of pixels associated with the user device can be positioned so that second content displayed via the second set of pixels can be viewable in a second viewing location. The second content can be different from the first content.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: July 18, 2023
    Assignee: Comcast Cable Communications, LLC
    Inventors: Edward David Monnerat, Jonathan Alan Leech, Nicholas Adam Pinckernell, Mehul Patel, Jasbir Rajpal, Garey Hoffman
  • Patent number: 11703149
    Abstract: An adapter for mounting cable hangers to a mounting structure includes: a plurality of mounting panels, each mounting panel including a mounting hole, the mounting panels attached to each other at edges thereof, each mounting panel being disposed at an angle relative to its adjacent mounting panels; a base attached to the edge of endmost ones of the mounting panels; wherein the mounting panels and the base define an interior of the adapter; the adapter further comprising at least one pair of fingers extending into the interior of the adapter, each pair of fingers being configured to cooperate to grasp a cable.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: July 18, 2023
    Assignee: CommScope Technologies LLC
    Inventors: Ronald A. Vaccaro, Aviral Joshi, Taig S. Rajpal
  • Patent number: 11675576
    Abstract: Systems and methods described herein provide an application priority optimization service. Application information associated with an application to be deployed at a Multi-access Edge Computing (MEC) network is received and parameters associated with execution of the application are determined based on the application information. The application is deployed at the MEC network and information associated with performance of the application is obtained. Resources allocated for execution of the application may be adjusted based on the performance of the application to create a modified application and the modified application may be executed at the MEC network.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: June 13, 2023
    Assignee: Verizon Patent and Licensing Inc.
    Inventors: Karthik Ramaswamy, Prashant Kumar Rajpal, Sivanaga Ravi Kumar Chunduru Venkata, Darshan Gupta
  • Patent number: 11672570
    Abstract: Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: June 13, 2023
    Assignee: SI-Bone Inc.
    Inventors: Mary E. Stuart, Bret W. Schneider, Francois Follini, Craig S. Bartlett, Bharat M. Desai, Michael J. Gardner, GianLuigi Moro, Sven H. Van Helden, Kyle L. Nishkian, David W. Polly, Jed S. Vanichkachorn, Andy J. Kranenburg, Sharad S. Rajpal, Nikolai G. Rainov
  • Patent number: 11674240
    Abstract: Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are derived from naturally-occurring antibodies expressed in response to a certain antigen class (e.g., small molecule, polysaccharide, peptide, or protein) and having CDR regions engineered for optimal diversity. Methods for making and screening such libraries for isolating therapeutics suitable for treating disease are also disclosed.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: June 13, 2023
    Assignee: Pfizer Inc.
    Inventors: Roberto Crea, Arvind Rajpal, Guido Cappuccilli, Randy Shen, Toshihiko Takeuchi
  • Publication number: 20230158227
    Abstract: An IV blood set foot pump includes a base plate, a squeezing plate movably coupled to the base plate by a pivot member and a biasing member coupled to the base plate and the squeezing plate. The biasing member is configured to exert a biasing force against the squeezing plate when the biasing member is in a compressed state. One of the base plate and the squeezing plate comprises a cavity configured to receive an IV pump bulb. IV sets with IV blood set foot pumps and methods of operating IV blood set foot pumps are also provided.
    Type: Application
    Filed: November 9, 2022
    Publication date: May 25, 2023
    Inventors: Vincent Vinh Nguyen, Rahul Rajan Puthukkad, Abhishek Krishnan, Sumit Rajpal, Kaushik Suman, Srinivas Ramakrishnarao Peddi, Aman Desai
  • Publication number: 20230154362
    Abstract: A cable hanger includes: a base panel having opposed ends; a pair of arms, each of the arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; and a pair of gripping members, each gripping member attached to a respective arm, each gripping member having opposed ends, wherein one of the ends of each gripping member is fixed to the arms and the other of the ends of each gripping member is fixed to the arm or to the base panel. The arms and locking projections are configured to spread apart to enable insertion of a cable between the arms, wherein the gripping projections engage and grip the cable, and wherein the locking projections are configured to be inserted into the aperture of the supporting structure.
    Type: Application
    Filed: January 5, 2023
    Publication date: May 18, 2023
    Inventors: Ronald A. Vaccaro, Aviral Joshi, Taig S. Rajpal
  • Publication number: 20230140384
    Abstract: Provided herein are agonist antibodies that bind to human CD40 with enhanced agonist activity. Such antibodies comprise Fc regions with amino acid substitutions that enhance the agonist activity of the antibody compared with a similar IgG1 antibody. Such substitutions include sequence variants in the IgG2 hinge region and sequence variants that enhance hexamerization of the antibodies. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
    Type: Application
    Filed: March 8, 2021
    Publication date: May 4, 2023
    Inventors: Arvind RAJPAL, Aaron Paul YAMNIUK, Pavel STROP, Bryan C. BARNHART, Feng WANG
  • Publication number: 20230119066
    Abstract: This disclosure provides isolated antibodies, for example, monoclonal antibodies, that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and mediate depletion of the CCR8-expressing cell by anti-body-dependent cellular cytotoxicity (ADCC). The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CCR8 antibody as monotherapy or in combination with an anti-cancer agent such as an immune checkpoint inhibitor, for example, an anti-PD-1 or anti-PD-L1 antibody.
    Type: Application
    Filed: March 22, 2021
    Publication date: April 20, 2023
    Inventors: Ruth Yin-Zong Lan, Olufemi A. Adelakun, Ishita Barman, Joseph Campbell, SJ Jian Zhe Diong, Felix Findeisen, Danielle M. Greenawalt, Renu Jain, Amy D. Jhatakia, John K. Lee, Peter S.K. Lee, Linda Liang, Kai Lu, Bryan McDonald, Paul Mesko, Arvind Rajpal, Sharmila Sambanthamoorthy, Mark J. Selby, Nathan O. Siemers, Pavel Strop, Gaby A. Terracina, Xi-Tao Wang
  • Patent number: 11623965
    Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: April 11, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Stanley R. Krystek, Jr., Yong Zhang, Gregory D. Vite, Arvind Rajpal, Chetana Rao-Naik, Paul E. Morin, Mohan Srinivasan, Zheng Lin, Virginie Lafont, Alla Pritsker
  • Patent number: 11602525
    Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: March 14, 2023
    Assignees: RINAT NEUROSCIENCE CORP., PFIZER INC.
    Inventors: Pavel Strop, Katherine Anne Delaria, Magdalena Dorywalska, Davide Luciano Foletti, Russell George Dushin, David Louis Shelton, Arvind Rajpal