Abstract: The present disclosure provides variant forms of anti-CTLA-4 antibodies, such as ipilimumab, that preferentially bind to CTLA-4 at low pH. Such antibody variants exhibit preferential activity in the tumor microenvironment, an enhanced ratio of anti-tumor response to side-effects, and an enhanced therapeutic index.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

Abstract: A request to activate a service may be received from a user device and a determination may be made as to whether the request is authorized or fraudulent. In particular, a geographical location of the user device may be determined. Whether to activate the service may be determined based on the geographical location of the user device.

Abstract: Techniques are described herein for network sliced based billing. In one example, a control center obtains, from a charging system, a charging data record that includes an indication of a network slice associated with a chargeable telecommunications event. Based on the indication of the network slice, the control center identifies a charging rate for the chargeable telecommunications event and applies the charging rate to the chargeable telecommunications event.

Abstract: A cable hanger includes: a base panel having opposed ends; a pair of arms, each of the arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; and a pair of gripping members, each gripping member attached to a respective arm, each gripping member having opposed ends, wherein one of the ends of each gripping member is fixed to the arms and the other of the ends of each gripping member is fixed to the arm or to the base panel. The arms and locking projections are configured to spread apart to enable insertion of a cable between the arms, wherein the gripping projections engage and grip the cable, and wherein the locking projections are configured to be inserted into the aperture of the supporting structure.

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

Abstract: Methods of identifying and using PSGL-1 antagonists are provided. Such methods include, but are not limited to, methods of treating cancer. PSGL-1 antagonists include, but are not limited to, antibodies that bind PSGL-1 and antibodies that bind VISTA, wherein the antibodies inhibit PSGL-1 binding to VISTA, e.g., at acidic pH (e.g., pH 6.0), as well as PSGL-1 and VISTA extracellular domain polypeptides.

Abstract: In one example, a charging filtering function may obtain a request for one or more rules that control whether or when one or more charging data records associated with a user equipment are to be provided to one or more billing systems. The request includes an identification of the user equipment. Based on the identification of the user equipment, the charging filtering function may identify the one or more rules. The charging filtering function may provide the one or more rules to control whether or when the one or more charging data records associated with the user equipment are to be provided to the one or more billing systems.

Abstract: The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Abstract: Methods, computing devices, and systems that dynamically determine whether a service request is authorized or fraudulent are described herein. A computing device may receive a request from a user device, and a geographical location of the user device may be determined based on a signal received from the user device. A determination as to whether to activate the service or not may be made based on the determined geographical location of the user device.

Abstract: An insert for mounting multiple cables in a cable hanger includes: a gripping portion configured to engage multiple cables; and a wrapping portion attached to the gripping portion and configured to wrap around the gripping portion as it receives cables.

Abstract: The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, wherein X1 is an amino acid X2 is an amino acid X3 is an amino acid and X4 is V or I.

Abstract: A cable hanger includes: a base panel having opposed ends; a pair of arms, each of the arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; and a pair of gripping members, each gripping member attached to a respective arm, each gripping member having opposed ends, wherein one of the ends of each gripping member is fixed to the arms and the other of the ends of each gripping member is fixed to the arm or to the base panel. The arms and locking projections are configured to spread apart to enable insertion of a cable between the arms, wherein the gripping projections engage and grip the cable, and wherein the locking projections are configured to be inserted into the aperture of the supporting structure.

Abstract: A cable hanger for mounting cables to a mounting structure includes: a base panel; a pair of arms attached to opposite ends of the base panel; and a pair of locking projections, each locking projection being attached adjacent a free end of a respective arm. Each arm is configured to define a respective internal cavity configured to grasp cable. The arms and the base panel combine to define an external cavity for grasping cable. The cable hanger can be deflected from a relaxed state to a deflected state by forcing the locking projections toward each other. In the deflected state the cable hanger may be mounted to a mounting structure, with the arms inserted through a hole in the mounting structure and exerting outward pressure on edges of the hole, and the locking projections maintaining the cable hanger in a mounted position on the mounting structure.

Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Abstract: An insert for mounting multiple cables in a cable hanger includes: a gripping portion configured to engage multiple cables; and a wrapping portion attached to the gripping portion and configured to wrap around the gripping portion as it receives cables.

Abstract: Disclosed are methods and systems for displaying content. In an aspect, a plurality of content items can be displayed on one user device according to user preference. An example method can comprise positioning a first set of pixels associated with a user device so that first content displayed via the first set of pixels can be viewable in a first viewing location. A second set of pixels associated with the user device can be positioned so that second content displayed via the second set of pixels can be viewable in a second viewing location. The second content can be different from the first content.

Abstract: The present invention relates to bispecific antibodies that specific bind to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). Method of making the bispecific antibodies and method of using the bispecific antibodies for the treatment of multiple myeloma are also provided.