Abstract: The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

Abstract: The present invention provides transgenic animals comprising some or all components of a human heavy and/or light chain immunoglobulin variable region locus, methods of making such animals, methods of making human antibodies using such animals, and methods of treatment using the human antibodies made in such animals, wherein the animals comprise in their genome a plurality of human heavy chain V gene segments all of which are immediately preceded by the same first leader peptide-encoding sequence, and/or a plurality of human light chain V gene segments all of which are immediately preceded by the same second leader peptide-encoding sequence, or both. The invention also provides polynucleotide constructs comprising two or more human heavy or light chain leader/V gene segments comprising identical leader peptide-encoding sequences.

Abstract: Devices, methods, and systems may obtain at least one point cloud, segment points in the at least one point cloud into a plurality of segments, train a neural network using known segments and a first loss function to generate a first trained neural network, train the first trained neural network using outlier segments and a second loss function to generate a second trained neural network, and train an extended isolation forest by applying an extended isolation algorithm to features of the known segments and features of the outlier segments to generate an anomaly score for each segment.

Abstract: Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.

Abstract: A cable hanger includes: a base panel having opposed ends; a pair of arms, each of the arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; and a pair of gripping members, each gripping member attached to a respective arm, each gripping member having opposed ends, wherein one of the ends of each gripping member is fixed to the arms and the other of the ends of each gripping member is fixed to the arm or to the base panel. The arms and locking projections are configured to spread apart to enable insertion of a cable between the arms, wherein the gripping projections engage and grip the cable, and wherein the locking projections are configured to be inserted into the aperture of the supporting structure.

Abstract: A cable hanger for securing cables to a supporting structure includes: a base panel having opposed ends; a pair of arms attached to a respective end of the base panel and having a free end; a pair of locking projections, each of the locking projections attached to a respective free end of the arms; a pair of gripping members, each gripping member attached with a respective arm or to the base panel, wherein the arms and locking projections are spread apart to enable insertion of a first cable between the arms, wherein the gripping members engage and grip the first cable, and wherein the locking projections are inserted into the aperture of the supporting structure; and at least one finger attached to and extending from one of the arms or the base panel, the finger configured to deflect and grasp a second cable against the arm or base panel.

Abstract: In one example, a charging filtering function may obtain a request for one or more rules that control whether or when one or more charging data records associated with a user equipment are to be provided to one or more billing systems. The request includes an identification of the user equipment. Based on the identification of the user equipment, the charging filtering function may identify the one or more rules. The charging filtering function may provide the one or more rules to control whether or when the one or more charging data records associated with the user equipment are to be provided to the one or more billing systems.

Abstract: An adapter for mounting cable hangers to a mounting structure includes: a plurality of mounting panels, each mounting panel including a mounting hole, the mounting panels attached to each other at edges thereof, each mounting panel being, disposed at an angle relative to its adjacent mounting panels; a base attached to the edge of endmost ones of the mounting panels; wherein the mounting panels and the base define an interior of the adapter; the adapter further comprising at least one pair of fingers extending into the interior of the adapter, each pair of fingers being configured to cooperate to grasp a cable.

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

Abstract: Systems and methods described herein provide an application priority optimization service. Application information associated with an application to be deployed at a Multi-access Edge Computing (MEC) network is received and parameters associated with execution of the application are determined based on the application information. The application is deployed at the MEC network and information associated with performance of the application is obtained. Resources allocated for execution of the application may be adjusted based on the performance of the application to create a modified application and the modified application may be executed at the MEC network.

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

Abstract: There are provided methods and corresponding systems for supporting Internet of Things (IoT) Trustworthiness as a Service (TaaS) related to an IoT device. The IoT device being arranged for connection to the Internet via a wired or wireless communication system. A method is based on an automated request-response procedure performed by a network entity acting as TaaS consumer, TaaS receiver or TaaS proxy to obtain a digital IoT certification proof representative of the trustworthiness of the IoT device from an IoT certification system acting as TaaS provider. The automated request-response procedure comprises requesting the digital IoT certification proof from the TaaS provider based on an identifier for locating the digital IoT certification proof for the IoT device, and receiving a response comprising the digital IoT certification proof from the TaaS provider to enable management and/or assessment of the trustworthiness of the IoT device.

Abstract: Methods of identifying and using PSGL-1 antagonists are provided. Such methods include, but are not limited to, methods of treating cancer. PSGL-1 antagonists include, but are not limited to, antibodies that bind PSGL-1 and antibodies that bind VISTA, wherein the antibodies inhibit PSGL-1 binding to VISTA, e.g., at acidic pH (e.g., pH 6.0), as well as PSGL-1 and VISTA extracellular domain polypeptides.

Abstract: A method, system and computer-usable medium are disclosed for tracking selected points in a series of images to determine motions made by a subject to perform an action to train a system, such as a machine or robot. A series of images are received depicting incremental steps of the subject performing the action. Selected points that are useful to track the subject performing the action are identified. Datasets of points used to train a model are mapped, and the model is trained using the mapped datasets of points.

Abstract: Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.

Abstract: Disclosed are methods and systems for displaying content. In an aspect, a plurality of content items can be displayed on one user device according to user preference. An example method can comprise positioning a first set of pixels associated with a user device so that first content displayed via the first set of pixels can be viewable in a first viewing location. A second set of pixels associated with the user device can be positioned so that second content displayed via the second set of pixels can be viewable in a second viewing location. The second content can be different from the first content.

Abstract: The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

Abstract: An adapter for mounting cable hangers to a mounting structure includes: a plurality of mounting panels, each mounting panel including a mounting hole, the mounting panels attached to each other at edges thereof, each mounting panel being disposed at an angle relative to its adjacent mounting panels; a base attached to the edge of endmost ones of the mounting panels; wherein the mounting panels and the base define an interior of the adapter; the adapter further comprising at least one pair of fingers extending into the interior of the adapter, each pair of fingers being configured to cooperate to grasp a cable.

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

Abstract: A computer-based system, and a computer-implemented method, mentors students, particularly women and ethnic and racial minorities, intending to enter healthcare professions. The system uses a gamified mobile-enabled web application (App) that serves as a visual and interactive dashboard populated with checklists, career support resources, strategies, tips, and a mentoring platform to educate, encourage, empower, and facilitate the entry of students into the healthcare professions.