Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

Abstract: Eight-bit ten-bit (8B10B) coding is provided in a hard intellectual property (IP) block with the capability of supporting a greater range of data rates (e.g., data rates less than, equal to, and greater than 3.125 Gbps). Each channel of high speed serial interface circuitry includes receiver circuitry having two 8B10B decoders and transmitter circuitry having two 8B10B encoders. The receiver and transmitter circuitry can be configured to operate in one of three modes of operation: cascade mode, dual channel mode, and single channel mode.

Abstract: Systems and methods for adjusting a signal received from a communication path are disclosed. A receiver can receive a signal from a communication path which attenuates at least some frequency components of the signal. The receiver can include an equalization block that adjusts at least some of the frequency content of the received signal, a signal normalization block that provides a normalized signal amplitude and/or a normalized edge slope, and a control block. In one embodiment, the control block controls frequency adjustment in the equalization block for high frequencies but not for low frequencies. For low frequency adjustment, the control block controls the normalized signal amplitude in the signal normalization block. In this manner, controlled adjustment for low frequency content is performed in the signal normalization block.

Abstract: A field-programmable gate array (“FPGA”) may include data receiver and/or transmitter circuitry that is adapted to receive and/or transmit data at any frequency(ies) or data rate(s) in a wide range of possible frequencies or data rates. Phase-locked loop (PLL) circuitry may be needed for operation of such receiver and/or transmitter circuitry. For satisfactory operation over the wide frequency range, multiple PLL circuits are provided. One of these PLL circuits may be capable of operating over the entire frequency range, possibly with better jitter performance in some portions of the range than in other portions of the range. One or more other PLL circuits may be provided that are focused on particular parts of the broad range, especially where the jitter performance of the first-mentioned PLL may not be adequate to meet some possible needs.

Abstract: A programmable logic device (“PLD”) is augmented with programmable clock data recover (“CDR”) circuitry to allow the PLD to communicate via any of a large number of CDR signaling protocols. The CDR circuitry may be integrated with the PLD, or it may be wholly or partly on a separate integrated circuit. The circuitry may be capable of CDR input, CDR output, or both. The CDR capability may be provided in combination with other non-CDR signaling capability such as non-CDR low voltage differential signaling (“LVDS”). The circuitry may be part of a larger system.

Abstract: Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.

Abstract: A programmable logic device has many regions of programmable logic, together with relatively general-purpose, programmable, interconnection resources that can be used to make interconnections between virtually any of the logic regions. In addition, various types of more local interconnection resources are associated with each logic region for facilitating the making of interconnections between adjacent or nearby logic regions without the need to use the general-purpose interconnection resources for those interconnections. The local interconnection resources support flexible clustering of logic regions via relatively direct and therefore high-speed interconnections, preferably in both horizontal and vertical directions in the typically two-dimensional array of logic regions. The logic region clustering options provided by the local interconnection resources are preferably boundary-less or substantially boundary-less within the array of logic regions.

Abstract: Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.

Abstract: A programmable logic device (PLD) having one or more programmable logic regions and one or more conventional input/output regions additionally has one or more peripheral areas including specialized circuitry. The peripheral specialized regions, which are not connected to the remainder of the programmable logic device (and may be made on separate dies from the remainder of the programmable logic device mounted on a common substrate), and one or both of the programmable logic regions and the conventional I/O regions, have contacts for metallization traces or other interconnections to connect the peripheral specialized regions to the remainder of the programmable logic device. The same PLD can be sold with or without the specialized circuitry capability by providing or not providing the interconnections. The peripheral specialized regions may include high-speed I/O (basic, up to about 3 Gbps, and enhanced, up to about 10-12 Gbps), as well as other types of specialized circuitry.

Abstract: Serial data signal receiver circuitry for inclusion on a PLD includes a plurality of equalizer circuits that are connected in series and that are individually controllable so that collectively they can compensate for a wide range of possible input signal attenuation characteristics. Other circuit features may be connected in relation to the equalizer circuits to give the receiver circuitry other capabilities. For example, these other features may include various types of loop-back test circuits, controllable termination resistance, controllable common mode voltage, and a controllable threshold for detection of an input signal. Various aspects of control of the receiver circuitry may be programmable.

Abstract: A programmable logic integrated circuit device has a plurality of regions of programmable logic disposed on the device in a plurality of intersecting rows and columns of such regions. Interconnection resources (e.g., interconnection conductors, signal buffers/drivers, programmable connectors, etc.) are provided on the device for making programmable interconnections to, from, and/or between the regions. At least some of these interconnection resources are provided in two forms that are architecturally similar (e.g., with similar and substantially parallel routing) but that have significantly different signal propagation speed characteristics. For example, a major or larger portion of such dual-form interconnection resources may have what may be termed normal signal speed, while a smaller minor portion may have significantly faster signal speed. Secondary (e.g.

Abstract: Equalization circuitry for receiving a digital data signal includes both feed-forward equalizer (“FFE”) circuitry and decision-feedback equalizer (“DFE”) circuitry. The FFE circuitry may be used to give the DFE circuitry a signal that is at least minimally adequate for proper start-up of the DFE circuitry. Thereafter, more of the burden of the equalization task may be shifted from the FFE circuitry to the DFE circuitry.

Abstract: Programmable duty cycle adjustment circuitry may be provided to correct for duty cycle distortion in serial data transmission systems. Duty cycle adjustment may be performed prior to transmitting data signals across a transmission medium. Duty cycle adjustment may also be performed as it is received from the transmission medium. Programmable duty cycle adjustment circuitry may be configured to adjust the rising and falling edges of data signals. Programmable duty cycle adjustment circuitry may also be configured to adjust the common mode level of data signals. The amount of duty cycle adjustment may be determined by end-users or through negative feedback.

Abstract: Data transmitter circuitry on a programmable logic device (“PLD”) includes a plurality of channels of serializer circuitry, and a plurality of clock multiplier units (“CMUs”), each of which is associated with a respective subplurality of the serializer channels. Each CMU includes multiple reference clock signal sources, multiple phase-locked loop (“PLL”) circuits, and circuitry for allowing any PLL to get its reference input from any of the reference sources. Raw and centrally processed clock signals produced by each CMU are distributed to the serializer channels associated with that CMU and, at least in the case of the centrally processed signals, to the serializer channels associated with another CMU. The signal that controls release of parallel data to each serializer channel can be an output signal of that channel, or it can be an output signal of any CMU from which that channel can get a clock signal.

Abstract: High speed transmitter drivers and other types of driver circuitry may be required to produce output signals with variable slew rates. Driver circuitry and methods for providing variable slew rate control are described. Pre-driver circuitry with variable slew-rate may be used to supply signals with variable slew rate at the driver input. The driver and/or pre-driver circuits may include transistors with variable drive strengths. The driver and/or pre-driver circuits may also include selectably enabled stages for varying the circuit drive strength. The pre-driver circuitry may be delay matched to maintain signal quality. Other circuitry and methods are also described.

Abstract: A serial interface for a programmable logic device supports a wide range of data rates by providing a first number of channels supporting a first range of data rates and a second number of channels supporting a second range of data rates. The first range of data rates is preferably lower than the second range of data rates and preferably the first number of channels is higher than the second number of channels which preferably is 1. For backward compatibility with existing devices, the first number of channels in each interface preferably is four. Each channel preferably includes a physical medium attachment module and a physical coding sublayer module. Each of the higher-speed channels in the second number of channels preferably also includes a clock management unit, while the lower-speed channels in the first number of channels preferably share one or more clock management units.

Abstract: A data converter, or “gearbox,” for a padded protocol interface can perform a number of different conversions—e.g., between 64 and 66 bits, between 24 and 26 bits, or between 48 and 50 bits. This is accomplished by clocking the gearbox at different clock speeds, all derived from the same master clock (which may be recovered from the data in a receiver embodiment) using programmable dividers that allow the user to select the clock speed. When the conversion is not that one with the maximum width for which the gearbox is designed, unused bits are ignored. The converter can also find padding bits, for alignment purposes, in data of different widths, again ignoring unused bits when the data are not the widest for which the converter is designed.

Abstract: A programmable technique is used to control the slew rate of a differential output buffer. A method controls the slew rate (SR) by changing an “on” resistance of the switches used to steer the current. This can be accomplished by (i) using different size switches or (ii) changing the slew rate of the predrivers which drive the final switches. The latter approach has the advantage that it only temporarily increases the “on” resistance, which does not cause any headroom problems after the transient. A specific application is for the differential outputs of a programmable logic integrated circuits.

Abstract: A serial interface for a programmable logic device provides multiple data rates in different channels by generating a central serial clock and providing at least one divider in each channel that can divide the central clock by different integer values. For additional variation in clock rate, two or more different central clocks can be provided, with each channel then being able to divide any of the central clocks to provide the desired local clock. Lower speed parallel clocks can be generated locally by further dividing the divided serial clock. Alternatively, the central serial clock or clocks may be divided centrally to provide a central parallel clock or clocks which can then be used locally as a local parallel clock.

Abstract: A serial interface for a programmable logic device can be operated according to various communications protocols and includes both a receiver portion and a transmitter portion. The receiver portion includes at least a word or byte alignment stage, a de-skew stage, a rate compensation or matching stage, a padded protocol decoder stage (e.g., 8B/10B decoder circuitry or 64B/66B decoder circuitry), a byte deserializer stage, a byte reorder stage, and a phase compensation stage. The transmitter portion includes at least a phase compensation stage, a byte deserializer stage, and a padded protocol encoder stage (e.g., an 8B/10B encoder circuitry or 64B/66B encoder circuitry). Each stage may have multiple occurrences of relevant circuitry. Selection circuitry, such as multiplexers, selects the appropriate stages, and circuitry within each stage, for the protocol being used.