Abstract: A method for making xanthan gum copolymer nanomicelles comprising: 1) degrading xanthan gum in aqueous solution to obtain degraded xanthan gum; 2) preparing xanthan gum bromide from the degraded xanthan gum; 3) preparing xanthan gum copolymer from the xanthan gum bromide and 4) making the gum copolymer nanomicelles from the xanthan gum copolymer. The xanthan gum copolymer nanomicelles have good morphological regularity, good biocompatibility and stable performance as an anticancer drug carriers.

Abstract: Anti-angiogenic agents or polypeptides have an amino acid segment substantially similar to domain one of CD2. The polypeptide has a ?-sheet formed by two segments. Methods of using such agents and polypeptide are also included.

Abstract: The invention relates to an ink based on near-infrared light polymerization. The method and technology of direct writing three-dimensional printing belong to the field of material processing technology area. The method is: direct writing nozzles move in three-dimensional space or stationery, the ink is squeezed out of the direct writing nozzle, receiving the near-infrared light irradiation, after curing, complete the three-dimensional object forming and curing. The solidifying time t does not exceed the ratio of near-infrared light diameter d1 and the ink extrusion speed vi, that is, t?d1/vi. Since near-infrared light has a better medium mass penetration, can penetrate the structure during molding to promote both internal and external to a higher degree of curing, so as to achieve cross-scale structure 3D printing, and the method provided by the present invention accurately controls solidifying process of the ink and therefore achieve the DIW array 3D structure real-time curing.

Abstract: The invention relates to an acrylic alloy composition that can be 3-D printed by a material extrusion additive manufacturing process, to an acrylic filament that has a very uniform diameter useful in the extrusion additive manufacturing process, to acrylic articles made from the acrylic alloy composition by a material extrusion additive process, and to a material extrusion additive manufacturing process for producing the acrylic articles. The acrylic alloy composition is an alloy of an acrylic polymer, and a low melt viscosity polymer, such as polylactic acid. The alloy may optionally be impact modified, preferably with hard core core-shell impact modifiers.

Abstract: Therapeutic proteins for inducing apoptosis in cells and method for using such proteins are described. The protein, e.g., a chimeric protein, has a host peptide fused to a more stable BH3 domain peptide. The host peptide may be Calbindin D9k, a N-terminal or C-terminal half-domain of Calmodulin, Parvalbimin (“Pa”), an amino acid sequence variant thereof, or a modified variant thereof. The BH3 domain may be Bim, Bid, Bad, Bik, Bmf, Hrk, Puma, or Noxia. Moreover, various conjugates may be attached to the chimeric protein, including a folate and polyethylene glycol.

Abstract: A dark-colored system photopolymerization composition, comprising: 20-80 phr of photopolymerizable prepolymer, 5-60 phr of photopolymerizable monomer, 0.2-8 phr of photoinitiator, and 0.1-5 phr of melanin, 0.05-5 phr of upconversion materials. The composition can construct photopolymerization under near-infrared irradiation. The dark pigment can avoid the strong absorption of near-infrared light, and the upconversion material can absorb near-infrared light with good penetrating ability and emit ultraviolet or visible light to induce the decomposition of free radicals or ionic photoinitiators in the composition. Then produced active species realize the photopolymerization of dark-colored compositions. The invention increases the depth of photopolymerization of dark-colored compositions and improves the mechanical properties of the polymer, that will broaden application fields of photopolymerization materials.

Abstract: The invention relates to an acrylic copolymer composition useful for 3-D printing, that can be formed into a uniform filament and 3-D printed using material extrusion additive manufacturing, into an article having low warpage, low shrinkage, good internal optical properties, and good mechanical properties. The acrylic copolymer has a low Tg, providing the proper stiffness for good 3-D printing. The invention also relates to the printing and processing of the acrylic composition where internally transparent 3-D printed thermoplastic parts can be produced at a reasonable rate (>0.05 mm per layer) with good/great layer adhesion, and near isotropic properties.

Abstract: A nanowire probe sensor array including a substrate with a metal pattern thereon. An array of semiconductor vertical nanowire probes extends away from the substrate, and at least some of probes, and preferably all, are individually electrically addressed through the metal pattern. The metal pattern is insulated with dielectric, and base and stem portions of the nanowires are also preferably insulated. A fabrication process patterns metal connections on a substrate. A semiconductor substrate is bonded to the metal pattern. The semiconductor substrate is etched to form the neural nanowire probes that are bonded to the metal pattern. Dielectric is then deposited to insulate the metal pattern.

Abstract: The invention relates a material extrusion additive manufacturing method for producing a clear, internally transparent part composed of amorphous thermoplastic polymer layers at least 0.1 mm thick. The invention also relates to internally clear parts made by the method, having an internal haze of less than 25%, less than 15%, less than 10% and even less than 5%. The method creates a printed dot or line of amorphous thermoplastic polymer that remains at a high internal temperature for a long enough period of time to allow the polymer chains in each layer to be mobile and fluid, permitting sufficient inter-layer chain entanglements to reduce and eliminate layer lines. With a nearly 100% dense final part, voids are eliminated. The resultant printed article has a very high internal clarity, and can have a haze of less than 5%.

Abstract: The invention relates to fluoropolymer filament for use in 3-D printing, and 3-D printed fluoropolymer articles having low warpage, excellent chemical resistance, excellent water resistance, flame resistance, and good mechanical integrity. Additionally, the articles of the invention have good shelf life without the need for special packaging. In particular, the invention relates to filament, 3-D printed polyvinylidene fluoride (PVDF) articles, and in particular material extrusion 3-D printing. The articles may be formed from PVDF homopolymers, copolymers, such as KYNAR® resins from Arkema, as well as polymer blends with appropriately defined low shear melt viscosity. The PVDF may optionally be a filled PVDF formulation. The physical properties of the 3-D printed articles can be maximized and warpage minimized by optimizing processing parameters.

Abstract: Devices and methods of the invention use a plurality of Fin structures and or combine a planar portion with Fin structures to compensate for the first derivative of transconductance, gm. In preferred methods and devices, Fins have a plurality of widths and are selected to lead to the separate turn-on voltage thresholds for the largest, intermediate and smallest widths of the MIS HEMT fins flatten the transconductance gm curve over an operational range of gate source voltage.

Abstract: Compositions and methods for inhibiting cancer cell metastasis and inflammation are disclosed. The methods generally involve administering to a subject a composition containing an agent that selectively inhibits the binding of p68 RNA helicase to calmodulin (CaM) in the cells.

Abstract: A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N?,N?-tetramethyl cystamine is prepared. The copolymer and N,N,N?,N?-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

Abstract: A modeling method for a high-density discrete particle multiphase system, including the following steps: determining a model boundary; drawing up a volume sum of particle phases within each size range in the model; generating compact models of particle models within all size ranges; expanding the particles in the compact models; and obtaining a high-density particle accumulation model. The method can be used for modeling of meso-structures of particle reinforced composite materials, granular materials in soft matter, particle accumulation materials and the like, and can also be extended to short fiber reinforced composite materials and the like. The method solves the modeling problem when the particles intersect with the model boundary, and can be applied to the modeling and analysis of composite specimens with machined surfaces.

Abstract: A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N?,N?-tetramethyl cystamine is prepared. The copolymer and N,N,N?,N?-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

Abstract: This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

Abstract: The invention relates to 3D printed parts made with thermoplastic polymers having a low stiffening temperature. 3D printed parts of the invention have very good Z layer adhesion, have a high elongation at break in the Z direction, preferably of more than 50 percent, and have at least an 80 percent ratio of Z to XY stress at yield or at break. The resulting part may be nearly isotropic—having similar mechanical properties in the XY and Z print directions. The excellent layer adhesion makes the resultant printed part more robust—able to withstand many cycles of use. Certain polymers of the invention produce printed parts that have a very low haze, and are nearly transparent.

Abstract: Disclosed is an ultra-high-power cementing apparatus integrated with remote control, belonging to the field of petroleum equipment. The apparatus includes a loading system, and a secondary beam on which a hydraulic system, a power transmission system, a metering tank, an electrical system, a gas path system, a manipulation system and a mixing system are successively connected from front to rear, wherein a lower portion of the gas path system is provided with a plunger pump that is connected to a high-pressure discharge system; and a lower portion of the electrical system is provided with a manipulation platform, the manipulation system being located above the manipulation platform, and the manipulation system being connected to a remote control system.

Abstract: Embodiments described herein are directed to polymerization-induced phase-separating (PIPS) compositions for enhancement of impact resistance and rheological properties in photocurable resins for 3D printing, such as for inks, coatings and adhesives. Embodiments described herein are advantageous with respect to properties such as impact resistance, shear adhesion and cohesive strength. The PIPS compositions may include components X, Y and Z, wherein X includes an acrylic based monomer; Y includes a copolymer of block A and block B; and Z includes a multifunctional cross-linker. Methods of using the PIPS compositions are also described. Also described are methods of screening potential acrylic based monomeric or oligomeric additives that yield improved impact resistance.

Abstract: A nanowire electrode array has a plurality of vertical nanowires extending from a substrate, each of the nanowires including a core of unitary first dielectric material that also covers the substrate and is unitary with the substrate. Each core has a sharp sub-100 nm diameter tip and a wider base, electrode leads on sidewalls to the tip of the nanowire, and second dielectric covering the electrode leads. The tips in the array can penetrate individual cells in cell culture, such as a mini-brain culture. The substrate can include a window for simultaneous optical imaging and electrophysiological recording.