Abstract: An adaptable ostomy base plate comprising a flexible top film, having a first section and a second section, and having at least a first elastic skin-friendly adhesive on a proximal surface of said flexible top film, a stoma-receiving through-going hole defining an inner boundary in said first section, said first section being adjacent to and extending radially from said through-going hole and said second section surrounding said first section defining an outer boundary of the base plate, and one or more release liners, the base plate has a substantially convex shape for initial engagement with a peristomal skin surface and can be inverted to a substantially concave shape to fittingly engage to a topography of the peristomal skin surface and the second section of the base plate is in the form of a plurality of petals extending away from the central area; and a plurality of bridges, each bridge formed between adjacent petals of the plurality of petals.

Abstract: Disclosed is a complementary material (20) dispenser attachable to an interior surface (30) of a top portion (28) of a collecting bag (22) for body waste to provide dispensing of complementary material (26) from the dispenser towards a material allocation zone (32) at the top portion (28) of the collecting bag. Also disclosed is an ostomy appliance system including a complementary material dispenser.

Abstract: A complementary-material element configured to be attachable to a base plate of an ostomy appliance and comprising a release layer, the element comprising a release layer comprises a neutralizing component configured to be releasable from the complementary-material element in response to subjection of the complementary-material element to moisture. The complementary-material element comprises a first surface and a second surface, wherein the first surface is provided with a first cover layer.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: A body side member of an ostomy appliance comprising a cover layer forming a distal surface having one or more openings to allow egression of a releasable material to be shifted between a first position underneath the cover layer to a second position on top of the cover layer in use of the body side member around a stoma of a user.

Abstract: A body side member of an ostomy appliance having a distal surface with one or more pockets holding a manipulable material and allowing the manipulable material to be shifted between a first position and a second position in the pocket in use of the body side member around a stoma of a user.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides vector compositions for delivering improved adoptive T cell therapies.

Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: A method for anal or stomal irrigation includes providing an irrigation system to a user and instructing the user to operate the system to expel the irrigating liquid from a catheter tip.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

Abstract: A urinary catheter assembly includes an intermittent urinary catheter disposed in a cavity formed by a handle, and a connector, and a sleeve attached between the handle and the connector. The connector has a drain. The drain is formed by an outer wall of the connector separated from an inner wall of the connector by a channel.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention relates to an insertion device comprising—a penetrating member (50) connected to transformation means (52), —a moving part (38) comprising guiding means (39) which guiding means (39) restrict the movement of the transformation means (52) and guide the penetrating member (50) from a first to a second position in a first direction, i.e. the direction of insertion, towards the injection site, and—a stationary housing (30) comprising guiding means (32) which guiding means (32) restrict the movement of the moving part (38). The guiding means (32) guide the moving part (38) in a second direction which is linear and different from the first direction i.e. the direction of insertion.

Abstract: A system for anal and/or stomal irrigation comprises a reservoir (102) for an irrigating liquid, a catheter (100) comprising a catheter tip for insertion into the rectum or stoma of a user and for expelling of the irrigating liquid from the catheter tip, and a tubing system (121) providing a conduit for the irrigating liquid between the reservoir and the catheter tip. A pump (101) is provided to pump the irrigating liquid from the reservoir to the catheter tip, and a control system (103) controls a flow condition, such as the amount of liquid expelled at the catheter tip. A sensor (153) determines a measure of pressure in at least one first predetermined position in the tubing system and/or the catheter during operation of the pump, on the basis of which the flow condition is estimated. The control system is configured to control the pumping operation of the pump in response to the measure of pressure.

Abstract: Disclosed is a complementary-material element (22) attachable to a base plate (24) of an ostomy appliance (20) and including a first entity (30) and a second entity (32). The entities comprise different material compositions. The material composition of the second entity comprises a neutralizer which is released from the complementary-material element in response to moisture, thereby neutralizing the damaging effects of stomal output.

Abstract: The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user.