Abstract: Vector compositions comprising a myeloproliferative sarcoma virus enhancer, negative control region deleted, dl587rev primer-binding site substituted (MND) promoter operably linked to a chimeric antigen receptor (CAR) are provided.

Abstract: A urinary catheter assembly having a sleeve is provided. The urinary catheter assembly comprises a urinary catheter (2) having a hydrophilic surface; the urinary catheter being provided with an insertion tip (5) in a proximal insertion end of the urinary catheter and an outlet (4) at a distal end of the urinary catheter, a handle (8) being slidingly disposed on the urinary catheter, a collapsible, flexible sleeve (7) attached to the handle and being configured to cover the urinary catheter from the outlet to the tip portion in an extended configuration of the urinary catheter assembly, the sleeve being attached to a connector (9) at the outlet, the connector and handle configured to be detachably attached to each other and define a cavity provided by the sleeve, handle and connector encapsulating an entirety of the urinary catheter in a storage condition.

Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: In certain embodiments an optimized derivative of the CCLc-?AS3-FB lentiviral vector termed (CCLc-mGata/ANK-CoreLCR-?AS3-FB), is provided which is capable of driving lineage-restricted expression of a beta-globin gene (e.g., an anti-sickling ?-globin like gene (?A83)). In certain embodiments the vectors described herein comprise novel defined LCR HS core sequences (HS2(˜420 bp), HS3?40 bp), HS4(˜410 bp)) which can be used to replace the putative LCR HS sequences present within the “mini-LCR” (˜3.6 kb reduced to ˜1.2 kb) to produce an “optimized mini-LCR”.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: A body side member of an ostomy appliance comprising a nonwoven element comprising a releasable material. Contact of the nonwoven element with liquid allow release of the releasable material from the nonwoven element. The releasable material may act to neutralise enzyme activity or pH of stomal exudate.

Abstract: The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: A system for anal irrigation is provided. The system includes a container, an anal probe, tubes and an electrical pump. The container has two configurations, a first collapsed configuration and a second expanded configuration. In the first configuration, a cavity for storing tubes and the anal probe is provided. In the second configuration, the container has a cavity for containing irrigation liquid. The pump and valves is stored in a cavity towards the bottom of the container.

Abstract: A perforated filtration insert includes a head unit and a body portion having perforated side walls. The body portion is closed at one end by a cap such that fluid entering the body exits through the perforations in the side walls of the insert.

Abstract: An ostomy wafer includes a stoma receiving hole formed through an adhesive layer and a backing layer of the ostomy wafer and has a central area formed as a continuous band of material around an entire perimeter of the stoma receiving hole. An outer periphery of the wafer is formed by a plurality of petals connected to and extending away from the central area, and a plurality of bridges is provided formed between adjacent petals of the plurality of petals. A thickness of the adhesive layer measured within one of the plurality of bridges is greater than a thickness of the adhesive layer measured within one of the plurality of petals.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.