Patents by Inventor Richard A. Mueller

Richard A. Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20050004043
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: February 24, 2004
    Publication date: January 6, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Michael Vazquez, Richard Mueller, John Talley, Daniel Getman, Gary DeCrescenzo, John Freskos
  • Retroviral protease inhibitors
    Publication number: 20050004230
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: March 5, 2004
    Publication date: January 6, 2005
    Applicant: Monsanto Company (now named Pharmacia Corporation, which is a wholly owned subsidiary of Pfizer, Inc
    Inventors: John Talley, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20040267022
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: January 2, 2004
    Publication date: December 30, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Alpha- and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20040229922
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: March 30, 2004
    Publication date: November 18, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Michael J. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
    Patent number: 6809083
    Abstract: Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: October 26, 2004
    Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis, Gary S. Jacob, Timothy M. Block, Raymond A. Dwek
  • Alpha-and beta-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Publication number: 20040171653
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: October 21, 2003
    Publication date: September 2, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Eric T. Sun
  • Retroviral protease inhibitors
    Patent number: 6762187
    Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: July 13, 2004
    Assignee: Monsanto Company
    Inventors: John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Kathryn L. Reed, Ko-Chung Lin, John Nicholas Freskos, Michael Clare, Donald Joseph Rogier, Jr., Robert M. Heintz, Michael L. Vazquez, Richard A. Mueller
  • Glucamine salts for treating hepatitis virus infections
    Patent number: 6747149
    Abstract: N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combination of such other agents.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: June 8, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6743929
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: June 1, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Apparatus and method for forming casingless sausages
    Patent number: 6740349
    Abstract: An apparatus and method is provided for forming shaped food products from an emulsion or batter. A stuffing tube includes a wall defining a central passage for emulsion, and a treating fluid passage positioned within the wall and radially outside of the central passage. The stuffing tube is slideably mounted coaxially within a mold tube. Emulsion and treating fluid are deposited into the mold tube during retraction of the stuffing tube from the mold tube, where the depositions occur substantially without relative motion between the emulsion and the treating fluid, or between the emulsion/treating fluid and the inside of the mold tube. A production machine incorporating an array of stuffing tubes can be indexed with a plurality of arrays of mold tubes.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: May 25, 2004
    Assignee: The Dial Corporation
    Inventors: Rodney L. Franklin, Marvin J. Mentjes, Richard A. Mueller, Charles A. Triplett, Andrew C. Harvey
  • Apparatus and method for forming casingless sausages
    Patent number: 6733812
    Abstract: An apparatus and method is disclosed for forming an emulsion or batter into shaped food products without the use of a casing. The apparatus includes a hollow stuffing tube connected to a source of suitable proteinaceous emulsion, and a molding tube mounted about the stuffing tube, the molding tube having an open end and a closed end. A supply of emulsion is conveyed under pressure into the stuffing tube to form a continuous length of shaped emulsion. Then, the shaped emulsion is directed into the molding tube, where the pressure of the emulsion bears against the closed end of the molding tube and causes the molding tube to move relative the stuffing tube. A treating fluid is directed to the interior surface of the molding tube, such that the interior surface is continuously wetted and evenly coated by the treating fluid, thereby forming a proteinaceous skin about the shaped emulsion.
    Type: Grant
    Filed: September 3, 2002
    Date of Patent: May 11, 2004
    Assignee: The Dial Corporation
    Inventors: Rodney L. Franklin, Marvin J. Mentjes, Richard A. Mueller, Charles A. Triplett
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6727282
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: April 27, 2004
    Assignee: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Alpha and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Publication number: 20040044047
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 4, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Michael J. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • &agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Patent number: 6683648
    Abstract: &agr;-and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: January 27, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Eric T. Sun
  • Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Publication number: 20040002542
    Abstract: Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: December 10, 2002
    Publication date: January 1, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Eric T. Sun
  • Method for preparing intermediates useful in synthesis of retroviral protease inhibitors
    Publication number: 20030225285
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Application
    Filed: February 10, 2003
    Publication date: December 4, 2003
    Applicant: G.D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Richard A. Mueller, Michael L. Vazquez, Daniel P. Getman
  • Apparatus and method for delivering therapeutic and diagnostic agents
    Publication number: 20030225370
    Abstract: The present invention provides an drug-delivery tool and method for delivering a selected diagnostic or therapeutic agent to a target site within a selected body tissue, such as the myocardium of the heart. In one embodiment, the drug-delivery tool is configured to be introduced percutaneously for intravascular delivery into temporary cavities formed in the myocardium from the epicardial surface. In another embodiment, the drug-delivery tool is configured for intraoperative use, to be introduced thoracoscopically or through a thoracotomy, to form temporary cavities in the myocardium from the epicardial surface. The drug-delivery tool generally comprises an accessing device having a tissue-penetrating implement in its distal-end region, and means for delivering a selected agent in a cavity formed by the implement.
    Type: Application
    Filed: February 20, 2003
    Publication date: December 4, 2003
    Applicant: Scimed Life Systems, Inc.
    Inventor: Richard Mueller
  • Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
    Publication number: 20030220299
    Abstract: N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combinations of such other agents.
    Type: Application
    Filed: January 14, 2003
    Publication date: November 27, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
  • Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inyhibitors
    Publication number: 20030220508
    Abstract: Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: September 9, 2002
    Publication date: November 27, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6646010
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: November 11, 2003
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Deborah E. Bertenshaw, Robert M. Heintz