Patents by Inventor Richard B. Silverman

Richard B. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition
    Publication number: 20160368877
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Application
    Filed: August 31, 2016
    Publication date: December 22, 2016
    Inventors: Richard B. Silverman, Maris A. Cinelli, Anthony V. Pensa
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20160347713
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: August 15, 2016
    Publication date: December 1, 2016
    Inventors: Richard B. Silverman, Qing Jing
  • Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 9499494
    Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: November 22, 2016
    Assignee: Northwestern University
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Guoyao Xia, Richard B. Silverman
  • SELECTIVE CALCIUM CHANNEL ANTAGONISTS
    Publication number: 20160310491
    Abstract: The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 27, 2016
    Inventors: Dalton J. Surmeier, JR., Richard B. Silverman, Soosung Kang, Garry Cooper
  • Tetrahydrothiophene-based GABA Aminotransferase Inactivators
    Publication number: 20160264544
    Abstract: Tetrahydrothiophene and related heterocyclic analogs and related methods for GABA aminotransferase inactivation.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 15, 2016
    Inventors: Richard B. Silverman, Hoang V. Le, Dustin D. Hawker
  • Selective calcium channel antagonists
    Patent number: 9428467
    Abstract: The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: August 30, 2016
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Dalton J. Surmeier, Jr., Richard B. Silverman, Soosung Kang, Garry Cooper
  • 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9416106
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: August 16, 2016
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Benzamide compounds and related methods of use
    Patent number: 9371277
    Abstract: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: June 21, 2016
    Assignees: Northwestern University, The General Hospital Corporation
    Inventors: Richard B. Silverman, Hua Wang, Mohammad Khanfar, Aleksey G. Kazantsev
  • Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20160152590
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Application
    Filed: January 25, 2016
    Publication date: June 2, 2016
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • Ornithine Aminotransferase Inhibition with GABA Analogues for Treatment of Hepatocellular Carcinoma
    Publication number: 20160128958
    Abstract: Therapeutic methods relating to the use of GABA-AT inhibitor compounds for the treatment of hepatocellular carcinoma.
    Type: Application
    Filed: November 9, 2015
    Publication date: May 12, 2016
    Inventors: Richard B. Silverman, Yaron llan
  • Mammalian and Bacterial Nitric Oxide Synthase Inhibitors
    Publication number: 20160122302
    Abstract: Compounds and related methods for inhibition of mammalian and bacterial nitric oxide synthase.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Richard B. Silverman, Qing Jing, Soosung Kang, Heng-Yen Wang
  • 2-Aminoquinoline-Based Compounds for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition
    Publication number: 20160096806
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Application
    Filed: December 14, 2015
    Publication date: April 7, 2016
    Inventors: Richard B. Silverman, Maris A. Cinelli, Anthony V. Pensa
  • Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20160096821
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Application
    Filed: December 14, 2015
    Publication date: April 7, 2016
    Inventors: Richard B. Silverman, Fengtian Xue
  • Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20160039740
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: October 20, 2015
    Publication date: February 11, 2016
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard J. Morimoto, Wei Zhang, Richard B. Silverman
  • Prodrugs of Fluorinated Mevalonates to Inhibit the Mevalonate Pathway of Streptococcus pneumoniae
    Publication number: 20160024042
    Abstract: Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition.
    Type: Application
    Filed: October 6, 2015
    Publication date: January 28, 2016
    Inventors: Richard B. Silverman, Mizuki Watanabe, Soosung Kang, Thomas S. Leyh
  • Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
    Patent number: 9242957
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: January 26, 2016
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20160016911
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Application
    Filed: September 28, 2015
    Publication date: January 21, 2016
    Inventors: Richard B. Silverman, Yinan Zhang
  • 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase
    Publication number: 20160009690
    Abstract: Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Inventors: Richard B. Silverman, Paramita Mukherjee, Hien M. Nguyen
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20150368201
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: August 31, 2015
    Publication date: December 24, 2015
    Inventors: Richard B. Silverman, Qing Jing
  • Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
    Patent number: 9212161
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: December 15, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue