Patents by Inventor Richard B. Silverman

Richard B. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaromatic selective inhibitors of neuronal nitric oxide synthase
    Patent number: 7470790
    Abstract: Compounds inhibiting neuronal nitric oxide synthase (nNOS) for potential treatment in neurodegenerative diseases, such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease, such compounds of a formula.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: December 30, 2008
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Haitao Ji
  • NOS Inhibitors For Treatment Of Motor Deficit Disorders
    Publication number: 20080176907
    Abstract: The present invention relates to preventive therapies and treatments of motor deficit disorders. In particular, the present invention relates to compositions and methods for preventative therapy and treatment of motor deficit disorders, such as cerebral palsy, in fetuses and newborn infants using inhibitors to neuronal nitric oxide synthase (nNOS).
    Type: Application
    Filed: September 19, 2007
    Publication date: July 24, 2008
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Haitao Ji, Sidhartha Tan, Matthew Derrick
  • Compounds and related methods for inhibition of gamma-aminobutyric acid aminotransferase
    Patent number: 7381748
    Abstract: (1S, 3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic acid illustrates a novel class of compounds as potent irreversible inhibitors of ?-aminobutyric acid aminotransferase (GABA-AT). The corresponding monofluoro-substituted compounds also are potent time-dependent inhibitors of GABA-AT.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: June 3, 2008
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Yue Pan
  • Selective neuronal nitric oxide synthase inhibitors
    Patent number: 6803486
    Abstract: Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: October 12, 2004
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Jung-Mi Hah, Jose Antonio Gomez Vidal
  • Compounds and related methods for inhibition of &ggr;-aminobutyric acid aminotransferase
    Patent number: 6794413
    Abstract: (1S, 3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic acid illustrates a novel class of compounds as potent irreversible inhibitors of &ggr;-aminobutyric acid aminotransferase (GABA-AT). The corresponding monofluoro-substituted compounds also are potent time-dependent inhibitors of GABA-AT.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: September 21, 2004
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Yue Pan
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Publication number: 20030225161
    Abstract: A compound of the formula 1
    Type: Application
    Filed: April 28, 2003
    Publication date: December 4, 2003
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Selective neuronal nitric oxide synthase inhibitors
    Publication number: 20030119751
    Abstract: Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.
    Type: Application
    Filed: June 24, 2002
    Publication date: June 26, 2003
    Inventors: Richard B. Silverman, Jung-Mi Hah, Jose Antonio Gomez Vidal
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6525096
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: February 25, 2003
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Organosilicon compounds and uses thereof
    Patent number: 6416861
    Abstract: A compound of the formula: and a resin-bound compound of the formula: and their use in combinatorial chemistry and in the synthesis of compounds comprising at least one aromatic moiety is described, where R1, R2, R3, R4, R5, R6, R7, L1, P, Ar1, and X are as herein defined.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: July 9, 2002
    Assignee: Northwestern University
    Inventors: Younghee Lee, Richard B. Silverman
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6414024
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 2, 2002
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6359169
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: March 19, 2002
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6342529
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: January 29, 2002
    Assignees: Northwestern University, Pfizer, Inc.
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6291526
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: September 18, 2001
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen
  • Inhibition of nitric oxide synthase by amino acids and dipeptides
    Patent number: 6274557
    Abstract: Methods and compositions for inhibiting at least one isoform of nitric oxide synthase are provided. Pharmaceutical compositions include derivatives of arginine as well as dipeptides and dipeptide analogs that contain nitroarginine or another unnatural amino acid. Compositions can be used to selectively inhibit particular isoforms of nitric oxide synthase.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: August 14, 2001
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Hui Huang, Henry Q. Zhang
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6262120
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 17, 2001
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6255345
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 3, 2001
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Gamma amino butyric acid analogs and optical isomers
    Patent number: 6197819
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: March 6, 2001
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6140366
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: October 31, 2000
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6117906
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: September 12, 2000
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6028214
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: February 22, 2000
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt