Patents by Inventor Richard B. Silverman

Richard B. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
    Patent number: 9212161
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: December 15, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue
  • 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
    Patent number: 9212144
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: December 15, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Maris A. Cinelli
  • Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
    Patent number: 9162968
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: October 20, 2015
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Prodrugs of fluorinated mevalonates to inhibit the mevalonate pathway of
    Patent number: 9150534
    Abstract: Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 6, 2015
    Assignees: Northwestern University, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Richard B. Silverman, Mizuki Watanabe, Soosung Kang, Thomas S. Leyh
  • Treatment of amyotrophic lateral sclerosis
    Patent number: 9145424
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: September 29, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Yinan Zhang
  • Intramolecular Hydrogen-Bonded Nitric Oxide Synthase Inhibitors
    Publication number: 20150252020
    Abstract: Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Application
    Filed: January 5, 2015
    Publication date: September 10, 2015
    Inventors: Richard B. Silverman, Fengtian Xue
  • 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Patent number: 9120750
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 1, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • 2-AMINOQUINOLINE-BASED COMPOUNDS FOR POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITION
    Publication number: 20150210644
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Application
    Filed: January 12, 2015
    Publication date: July 30, 2015
    Inventors: Richard B. Silverman, Maris A. Cinelli
  • Specific nNOS inhibitors for the therapy and prevention of human melanoma
    Patent number: 9090589
    Abstract: Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: July 28, 2015
    Assignees: Northwestern University, The Regents of the University of California
    Inventors: Richard B. Silverman, Frank L. Meyskens, Sun Yang, Haitao Ji, Fengtian Xue, Thomas L. Poulos
  • PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20150203456
    Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
    Type: Application
    Filed: October 4, 2013
    Publication date: July 23, 2015
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Richard B. Silverman, Guoyao Xia
  • METHODS OF USING (1S,3S)-3-AMINO-4-DIFLUOROMETHYLENYL-1-CYCLOPENTANOIC ACID
    Publication number: 20150196522
    Abstract: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 can be used to treat addiction and neurological disorders without side effects such as visual field defects caused by vigabatrin (Sabril).
    Type: Application
    Filed: March 2, 2015
    Publication date: July 16, 2015
    Inventors: Richard B. SILVERMAN, Steven MILLER
  • Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid
    Patent number: 8969413
    Abstract: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: March 3, 2015
    Assignees: Catalyst Pharmaceutical Partners, Brookhaven Science Associates, Northwestern University
    Inventors: Richard B. Silverman, Stephen L. Dewey, Steven Miller
  • Benzamide Compounds and Related Methods of Use
    Publication number: 20150025235
    Abstract: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.
    Type: Application
    Filed: May 30, 2014
    Publication date: January 22, 2015
    Inventors: Richard B. Silverman, Hua Wang, Mohammad Khanfar, Aleksey G. Kazantsev
  • Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20150018388
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Application
    Filed: December 11, 2013
    Publication date: January 15, 2015
    Inventors: Richard B. Silverman, Yinan Zhang
  • Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
    Patent number: 8932842
    Abstract: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: January 13, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue, He Huang
  • Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
    Patent number: 8927730
    Abstract: Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: January 6, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtlan Xue
  • Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis
    Publication number: 20140371313
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: May 12, 2014
    Publication date: December 18, 2014
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • 2-Aminopyridine-based Selective Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20140256016
    Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 11, 2014
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Qing Jing
  • Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors
    Publication number: 20140256958
    Abstract: Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Inventors: Richard B. Silverman, He Huang, Qing Jing
  • Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
    Patent number: 8829187
    Abstract: Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: September 9, 2014
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Fengtian Xue