Patents by Inventor Richard B. Silverman

Richard B. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of Ornithine Aminotransferase for the Treatment of Proliferative Disorders
    Publication number: 20120245380
    Abstract: The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.
    Type: Application
    Filed: May 31, 2012
    Publication date: September 27, 2012
    Applicant: Hadasit Medical Research Services & Development Ltd.
    Inventors: Yaron ILAN, Ehud ZIGMOND, Richard B. SILVERMAN, Hejun LU
  • Specific nNOS Inhibitors for the Therapy And Prevention Of Human Melanoma
    Publication number: 20120238016
    Abstract: Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.
    Type: Application
    Filed: January 12, 2012
    Publication date: September 20, 2012
    Inventors: Frank L. Myskens, JR., Richard B. Silverman, Sun Yang, Haitao Ji, Fengtian Xue, Thomas L. Poulos
  • SELECTIVE CALCIUM CHANNEL ANTAGONISTS
    Publication number: 20120196883
    Abstract: The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.
    Type: Application
    Filed: January 19, 2012
    Publication date: August 2, 2012
    Inventors: Dalton J. Surmeier, JR., Richard B. Silverman, Soosung Kang, Garry Cooper
  • Inhibition of ornithine aminotransferase for the treatment of proliferative disorders
    Patent number: 8211865
    Abstract: The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: July 3, 2012
    Assignee: Hadasit Medical Research Services & Development, Ltd.
    Inventors: Yaron Ilan, Ehud Zigmond, Richard B. Silverman, Hejun Lu
  • CYCLIC PEPTIDE ANTITUMOR AGENTS
    Publication number: 20120122799
    Abstract: Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
    Type: Application
    Filed: November 14, 2011
    Publication date: May 17, 2012
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Shouxin Liu, Wenxin Gu, Thomas E. Adrian, Gerald A. Soff
  • Heteroaromatic selective inhibitors of neuronal nitric oxide synthase
    Patent number: 8158658
    Abstract: Compounds selectively inhibiting neuronal nitric oxide synthase (nNos), such compounds of a formula wherein the variables are defined, herein.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: April 17, 2012
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Haitao Ji
  • Intramolecular Hydrogen-Bonded Nitric Oxide Synthase Inhibitors
    Publication number: 20120088798
    Abstract: Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Application
    Filed: September 30, 2011
    Publication date: April 12, 2012
    Inventors: Richard B. Silverman, Fengtian Xue
  • PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20120046309
    Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
    Type: Application
    Filed: May 5, 2010
    Publication date: February 23, 2012
    Applicants: NORTHWESTERN UNIVERSITY, CAMBRIA PHARMACEUTICALS, INC.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Richard B. Silverman, Guoyao Xia
  • Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors
    Publication number: 20120004415
    Abstract: A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.
    Type: Application
    Filed: July 1, 2011
    Publication date: January 5, 2012
    Inventors: Richard B. Silverman, Fengtian Xue
  • Cyclic peptide antitumor agents
    Patent number: 8058244
    Abstract: Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: November 15, 2011
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Shouxin Liu, Wenxin Gu, Thomas E. Adrian, Gerald A. Soff
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20110237907
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Application
    Filed: November 20, 2009
    Publication date: September 29, 2011
    Applicants: CAMBRIA PHARMACEUTICALS, INC., NORTHWESTERN UNIVERSITY
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Tian Chen, Richard B. Silverman
  • Potent and highly selective heteroaromatic inhibitors of neuronal nitric oxide synthase
    Patent number: 7994326
    Abstract: Peptidomimetic compounds as can inhibit neuronal nitric oxide synthase (nNOS) for potential treatment in neurodegenerative diseases, such as but not limited to stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: August 9, 2011
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Haitao Ji, Graham R. Lawton
  • Inhibitors of the mevalonate pathway of streptococcus pneumoniae
    Publication number: 20110178043
    Abstract: Compounds and related methods as can be used for selective mevalonate pathway inhibitors.
    Type: Application
    Filed: November 9, 2007
    Publication date: July 21, 2011
    Inventors: Richard B. Silverman, Takashi Kudoh
  • Chiral Pyrrolidine Core Compounds en route to Inhibitors of Nitric Oxide Synthase
    Publication number: 20100292484
    Abstract: Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.
    Type: Application
    Filed: May 17, 2010
    Publication date: November 18, 2010
    Inventors: Richard B. Silverman, Fengtian Xue
  • Cyclic Peptide Antitumor Agents
    Publication number: 20100204088
    Abstract: Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
    Type: Application
    Filed: March 11, 2010
    Publication date: August 12, 2010
    Inventors: Richard B. Silverman, Shouxin Liu, Wenxin Gu, Thomas E. Adrian, Gerald A. Soff
  • Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition
    Publication number: 20100203613
    Abstract: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 12, 2010
    Inventors: Richard B. Silverman, Fengtian Xue
  • Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors with Improved Membrane Permeability
    Publication number: 20100190230
    Abstract: Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
    Type: Application
    Filed: January 25, 2010
    Publication date: July 29, 2010
    Inventors: Richard B. Silverman, Fengtian Xue
  • Cyclic peptide antitumor agents
    Patent number: 7709443
    Abstract: Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: May 4, 2010
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Shouxin Liu, Wenxin Gu, Thomas E. Adrian, Gerald A. Soff
  • Heteroaromatic Selective Inhibitors of Neuronal Nitric Oxide Synthase
    Publication number: 20090104677
    Abstract: Compounds inhibiting neuronal nitric oxide synthase (nNOS) for potential treatment in neurodegenerative diseases, such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease, such compounds of a formula.
    Type: Application
    Filed: December 30, 2008
    Publication date: April 23, 2009
    Inventors: Richard B. Silverman, Haitao Ji
  • Selective neuronal nitric oxide synthase inhibitors
    Patent number: 7470815
    Abstract: Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: December 30, 2008
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Jung-Mi Hah, Jose Antonio Gomez Vidal, Erik Erdal