Abstract: A band-pass clock distribution circuit includes a clock tree circuit including at least one clock buffer circuit. The clock tree circuit may be configured to receive a first clock signal from a clock generator circuit and to generate a second clock signal based on the first clock signal. A band-pass filter may be configured to receive the second clock signal and to provide a third clock signal to one or more load circuits. The band-pass filter includes a filtering resonant network including a first inductor and a second inductor coupled to one another at a center tap. The filtering resonant network is configurable to resonate with a parasitic capacitance associated with the one or more load circuits. A portion of the band-pass filter is integrated with the clock tree circuit.

Abstract: A method of correcting mass spectral data comprises making calibration measurements at one or more calibration times using calibrants which have known mass to charge ratio (m/z) values or previously mass measured mass to charge ratio (m/z) values, making a list of intrinsic components which are present during more than one acquisition periods, wherein the components have mass to charge ratio (m/z) values that were not present or observed during or close to the one or more calibration times, and utilising the list to calculate a mass or mass to charge ratio (m/z) correction factor for one or more acquisition periods which are not close or adjacent in time to an acquisition period containing a directly calibrated mass to charge ratio (m/z) value.

Abstract: A method of time of flight (ToF) mass spectrometry comprising: pushing ions into a ToF mass analyser in a plurality of pushes, wherein the time spacing between adjacent pushes is shorter than either the longest flight time, or the range of flight times, of the ions; detecting the ions so as to obtain spectral data; decoding the spectral data to determine first mass spectral data relating to ions pushed into the ToF mass analyser by a first plurality of the pushes (P1-P4), and allocating this first mass spectral data to a first time stamp (t1); and decoding the spectral data to determine second mass spectral data relating to ions pushed into the ToF mass analyser by a second plurality of the pushes (P5-P8), and allocating this second mass spectral data to a second time-stamp (t2); wherein the first and second time-stamps have a time difference therebetween that is shorter than said longest flight time, or said range of flight times (4), in the ToF mass analyser.

Abstract: A method of configuring a string of pulses for an encoded frequent pulsing (EFP) acquisition, comprising: (a) generating a string containing N pulses, each pulse occurring at a respective time tn, the string of length T, wherein in use the string of pulses is repeated to create a stream of pulses; (b) calculating the respective span intervals ?tn(k) between each pulse and every other pulse in the string, wherein k is the number of pulses in the span interval ?tn(k) (k being between 1 and N); (c) determining the degree of overlap D of the calculated span intervals ?tn by calculating the relative difference ??t therebetween; (d) calculating the degree of uniformity S of the string of pulses; (e) calculating an objective function F=S?D for the string of pulses; (f) reconfiguring the string to alter the time tn of at least one pulse in the string; (g) calculating the objective function F? for the reconfigured string and, if F? is higher than F, adopting the reconfigured string.

Abstract: There is provided a method of decoding a first data set obtained from a time of flight (ToF) mass analyser operating according to an encoded frequency pulsing (EFP) scheme. The method comprises generating a mock data set based on a model set of ions taking account of the EFP pattern and the flight time distribution of the ions. The model set of ions is then iteratively updated using the first data set to determine a second, decoded data set.

Abstract: A hybrid digital-to-analog converter (DAC) driver circuit includes a current-mode DAC driver, a voltage-mode DAC driver, and a combination circuit. The current-mode DAC driver may be configured to receive a first set of bits of a digital input signal and to generate a first analog signal. The voltage-mode DAC driver may be configured to receive a second set of bits of the digital input signal and to generate a second analog signal. The combination circuit may be configured to combine the first analog signal and the second analog signal and to generate an analog output signal. The DAC driver circuit may be terminated by adjusting resistor values of the voltage-mode DAC driver. The current-mode DAC driver and the voltage-mode DAC driver are differential drivers, and may be configured to operate with a single clock signal.

Abstract: A method of correcting mass spectral data comprises making calibration measurements of first intrinsic components (A, B, C) at one or more calibration times (t1) using calibrants which have known mass to charge ratio (m/z) values or previously mass measured mass to charge ratio (m/z) values, making a list of second intrinsic components (D, E, F) which are present during more than one acquisition periods, wherein the second intrinsic components have mass to charge ratio (m/z) values that were not present or observed during or close to the one or more calibration times (t1) but which do overlap in time with the first intrinsic components (A, B, C), and utilising the list to calculate a mass or mass to charge ratio (m/z) correction factor for one or more acquisition periods which are not close or adjacent in time to an acquisition period containing a directly calibrated mass to charge ratio (m/z) value.

Abstract: A band-pass clock distribution circuit includes a clock tree circuit including at least one clock buffer circuit. The clock tree circuit may be configured to receive a first clock signal from a clock generator circuit and to generate a second clock signal based on the first clock signal. A band-pass filter may be configured to receive the second clock signal and to provide a third clock signal to one or more load circuits. The band-pass filter includes a filtering resonant network including a first inductor and a second inductor coupled to one another at a center tap. The filtering resonant network is configurable to resonate with a parasitic capacitance associated with the one or more load circuits. A portion of the band-pass filter is integrated with the clock tree circuit.

Abstract: A hybrid digital-to-analog converter (DAC) driver circuit includes a current-mode DAC driver, a voltage-mode DAC driver, and a combination circuit. The current-mode DAC driver may be configured to receive a first set of bits of a digital input signal and to generate a first analog signal. The voltage-mode DAC driver may be configured to receive a second set of bits of the digital input signal and to generate a second analog signal. The combination circuit may be configured to combine the first analog signal and the second analog signal and to generate an analog output signal. The DAC driver circuit may be terminated by adjusting resistor values of the voltage-mode DAC driver. The current-mode DAC driver and the voltage-mode DAC driver are differential drivers, and may be configured to operate with a single clock signal.

Abstract: The present technology relates to a method and instrument for classifying a sample. The method collects raw data from an analytical instrument (e.g., LC-MS), quantifies consistency parameters from the raw chromatographic data (e.g., peak detection) by assigning criteria and determining probability ratios, and constructs a learning model quantitation step by weighing the presence, absence, or modulation of one or more factors of the one or more samples against a decision criterion for positivity. The method can then apply the learning model to an unknown sample to detect the presence, absence, or modulation of one or more factors in the unknown sample such as the presence, absence, or modulation of a disease state or multiple disease states.

Abstract: An entrainment-based filtering system for use in connection with a facemask or respirator that includes: a filter housing defining an interior volume comprising at least one airflow pathway having an airflow pathway length that is longer than the length of the interior volume and spaced within the interior volume; and a plurality of entrainment substrates. The plurality of entrainment substrates is positioned within the at least one airflow pathway and the plurality of substrates and the dimensions of the at least one airflow pathway together function to entrain particles on the surface of the chemically coated entrainment substrates and prevent at least 95% of particles traveling through the at least one airflow pathway from exiting the entrainment-based filter.

Abstract: Methods of calibrating a mass spectrometer include: experimentally determining the mass to charge ratios of a plurality of chemical compounds in a reference standard using a mass spectrometer configured to scan ions at a first scan speed; experimentally determining the mass to charge ratios of said plurality of chemical compounds in said reference standard using a mass spectrometer configured to scan ions at a second scan speed; generating sets of data corresponding to each chemical compound, each set of data comprising the experimentally determined mass to charge ratios and the first and second scan speeds; interpolating from the sets of data mass to charge ratio for each chemical compound at a scan speed different from the first and second scan speeds; and constructing a calibration curve using the mass to charge ratios interpolated from the sets of data.

Abstract: A method of analysing a sample comprises analysing a sample in a first mode of operation so as to produce a spatially resolved data set representative of the sample, and analysing the data set so as to identify one or more regions of the sample. For each of one or more identified regions of the sample, a tandem mass spectrometry (MS/MS) data set is produced for that region by determining a path through the region, and analysing the sample along the path using Desorption Electrospray Ionisation (“DESI”) in a tandem mass spectrometry (MS/MS) mode of operation.

Abstract: A band-pass clock distribution circuit includes a clock tree circuit including at least one clock buffer circuit. The clock tree circuit may be configured to receive a first clock signal from a clock generator circuit and to generate a second clock signal based on the first clock signal. A band-pass filter may be configured to receive the second clock signal and to provide a third clock signal to one or more load circuits. The band-pass filter includes a filtering resonant network including a first inductor and a second inductor coupled to one another at a center tap. The filtering resonant network is configurable to resonate with a parasitic capacitance associated with the one or more load circuits. A portion of the band-pass filter is integrated with the clock tree circuit.

Abstract: A band-pass clock distribution circuit includes a clock tree circuit including at least one clock buffer circuit. The clock tree circuit may be configured to receive a first clock signal from a clock generator circuit and to generate a second clock signal based on the first clock signal. A band-pass filter may be configured to receive the second clock signal and to provide a third clock signal to one or more load circuits. The band-pass filter includes a filtering resonant network including a first inductor and a second inductor coupled to one another at a center tap. The filtering resonant network is configurable to resonate with a parasitic capacitance associated with the one or more load circuits. A portion of the band-pass filter is integrated with the clock tree circuit.

Abstract: Techniques for real-time or substantially real-time peak detection are described. In one embodiment, for example, logic coupled to memory may be configured to receive data from at least one analytical instrument and perform processing or analysis on the received data. Moreover, the logic may be configured to determine, via one or more GPUs or CPUs (or both), one or more peaks based on the processing or the analysis of the received data and generate peak detection data based on the detected one or more peaks in real-time or substantially real-time. Other embodiments are described.

Abstract: Disclosed herein is a method of processing mass spectral data comprising making direct calibration measurements to determine a calibration shift of the mass spectrometry instrument at a calibration time and determining a set of intrinsic ion species that persist across multiple acquisition periods. The direct calibration measurements are then used together with an expected variation in calibration shift as well as the set of intrinsic ion species to calculate the calibration shift of the mass spectrometry instrument at one or more time point(s) of interest other than the calibration time.

Abstract: There is provided a method of decoding a first data set obtained from a time of flight (ToF) mass analyser operating according to an encoded frequency pulsing (EFP) scheme. The method comprises generating a mock data set based on a model set of ions taking account of the EFP pattern and the flight time distribution of the ions. The model set of ions is then iteratively updated using the first data set to determine a second, decoded data set.

Abstract: System and method for providing patient-specific models to distinguish between epochs of electrocardiograms (ECGs) located far away from atrial fibrillation rhythms and those located just prior to the onset of those episodes, to provide for the prediction of the onset of an occurrence of atrial fibrillation (AF) in the patient.

Abstract: Systems and methods for solvent-free direct extraction of target compounds from compositions of matter are disclosed herein. The disclosed systems and methods use low pressure to reduce the evaporation temperature of target compounds without affecting the chemical integrity thereof. Target compounds are extracted from the composition of matter in an evacuation chamber and then collected using a capture system. Target compounds may be drawn from the evacuation chamber into the capture system using a carrier gas to facilitate transport of the targeted compounds in the vapor phase. A processed vapor stream may be transported from the capture system back into the evacuation chamber using a recirculation system that includes a blower. The disclosed systems and methods may be used, for example, to extract target compounds from plant matter such as fresh or dried cannabis and hemp, lavender, rosemary, lilac, or other suitable plant matter containing desirable compounds for extraction.